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在庫・価格 : 2024年05月01日 08時51分 現在

商品名 商品コード メーカー 包装 価格 在庫 リスト
Anti-HIF Prolyl Hydroxylase 2, Rabbit-Poly <Anti-PHD2> <Anti-EGLN1>
データシート
NB100-137 NOVノバス バイオロジカルス
Novus biologicals, LLC
0.1 ml ¥103,000
(未発注)
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在庫・価格 : 2024年05月01日 08時51分 現在

Anti-HIF Prolyl Hydroxylase 2, Rabbit-Poly <Anti-PHD2> <Anti-EGLN1>

  • 商品コード:NB100-137
  • メーカー:NOV
  • 包装:0.1ml
  • 価格: ¥103,000
  • 在庫:無(未発注)
使用文献
No. 文献情報 備考 参照
1 Asikainen TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul;102(29):10212-7
Asikainen TM et al
2005/01/01
PubMed
2 Jokilehto T et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin. Cancer Res. 2006 Feb;12(4):1080-7
Jokilehto T et al
2006/01/01
PubMed
3 Elvidge GP et al. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J. Biol. Chem. 2006 Jun;281(22):15215-26
Elvidge GP et al
2006/01/01
PubMed
4 Ietta F et al. Dynamic HIF1A regulation during human placental development. Biol. Reprod. 2006 Jul;75(1):112-21
Ietta F et al
2006/01/01
PubMed
5 McMahon S et al. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J. Biol. Chem. 2006 Aug;281(34):24171-81
McMahon S et al
2006/01/01
PubMed
6 Barth S et al. The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol. Cell. Biol. 2007 May;27(10):3758-68
Barth S et al
2007/01/01
PubMed
7 Weroha SJ et al. Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma. Gynecol. Oncol. 2011 Jul;122(1):116-20
Weroha SJ et al
2011/01/01
PubMed
8 Manalo DJ et al. Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1&#x3B1;) and induces hepcidin (Hamp) in rat kidney. Biochem. Biophys. Res. Commun. 2011 Dec;416(3-4):421-6
Manalo DJ et al
2011/01/01
PubMed
9 Baek JH et al. Induction of hypoxia inducible factor (HIF-1&#x3B1;) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim. Biophys. Acta ;1809(4-6):262-8
Baek JH et al
PubMed
10 Vogel S et al. Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation. J. Biol. Chem. 2010 Oct;285(44):33756-63
Vogel S et al
2010/01/01
PubMed
11 Schultz K et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 2009 Jun;296(6):L921-7
Schultz K et al
2009/01/01
PubMed
12 Wang Z et al. Hypoxia-inducible factor-1&#x3B1; contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int. 2011 Feb;79(3):300-10
Wang Z et al
2011/01/01
PubMed
13 Wollenick K et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012 Mar;40(5):1928-43
Wollenick K et al
2012/01/01
PubMed
14 H旦gel H et al. Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS ONE 2011;6(11):e27112
H旦gel H et al
2011/01/01
PubMed
15 Brockmeier U et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS ONE 2011;6(4):e19151
Brockmeier U et al
2011/01/01
PubMed
16 Luo W et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011 May;145(5):732-44
Luo W et al
2011/01/01
PubMed
17 Wu YL et al. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J. Cell. Sci. 2006 Jul;119(Pt 13):2797-806
Wu YL et al
2006/01/01
PubMed
18 Li N et al. Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. Am. J. Physiol. Renal Physiol. 2007 Jan;292(1):F207-16
Li N et al
2007/01/01
PubMed
19 Yin L et al. Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia. J. Biol. Chem. 2007 Jan;282(1):257-66
Yin L et al
2007/01/01
PubMed
20 Rantanen K et al. Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation. Mol. Biol. Cell 2008 May;19(5):2231-40
Rantanen K et al
2008/01/01
PubMed
21 Aprelikova O et al. Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res. 2009 Jan;69(2):616-24
Aprelikova O et al
2009/01/01
PubMed
22 Nandal A et al. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab. 2011 Nov;14(5):647-57
Nandal A et al
2011/01/01
Applications: WB, Species: Human PubMed
23 Niecknig H et al. Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic. Res. 2012 Jun;46(6):705-17
Niecknig H et al
2012/01/01
Applications: WB, Species: Human PubMed
24 Fujita N et al. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1&#x3B1; activity in hypoxia.
Fujita N et al
2012/01/01
Applications: ICC, IF, WB, Species: Human, Rat PubMed
25 Verstraete M et al. Investigation of possible endogenous hypoxia markers in colorectal cancer. Int. J. Radiat. Biol. 2012 Aug;
Verstraete M et al
2012/01/01
Species: Human, Applications: IHC PubMed
26 Jokilehto T. The Cellular Oxygen Sensor PHD2 in Cancer Growth 2011. Doctoral thesis, University of Turku, Finland.

PubMed
27 Jokilehto T et al. Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth. Exp. Cell Res. 2010 Apr;316(7):1169-78
Jokilehto T et al
2010/01/01
Applications: IHC, WB PubMed
28 Persano L et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1&#x3B1; stability and MGMT expression. Cell Death Dis 2012;3:e412
Persano L et al
2012/01/01
Species: Human, Applications: WB PubMed
29 De Saedeleer CJ et al. Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells. PLoS ONE 2012;7(10):e46571
De Saedeleer CJ et al
2012/01/01
Species: Human, Applications: WB PubMed
30 Han WQ et al. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim. Biophys. Acta 2013 Jun;1833(6):1454-62
Han WQ et al
2013/01/01
PubMed
31 Kaufmann MR et al. Dysregulation of hypoxia-inducible factor by presenilin/&#x3B3;-secretase loss-of-function mutations. J. Neurosci. 2013 Jan;33(5):1915-26
Kaufmann MR et al
2013/01/01
Species: Human, Applications: WB PubMed
32 Wottawa M et al. Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-&#x3B2;1 processing. Int. J. Cancer 2013 Jun;132(12):2787-98
Wottawa M et al
2013/01/01
Species: Human, Applications: WB, IHC PubMed
33 Luukkaa M et al. Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck. Int. J. Radiat. Biol. 2009;85(10):900-8
Luukkaa M et al
2009/01/01
Species: Human, Applications: IHC-P PubMed
34 Tan JT et al. High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1&#x3B1;. FASEB J. 2014 Jan;28(1):206-17
Tan JT et al
2014/01/01
Species: Human, Applications: WB PubMed
35 Bordoli MR et al. Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis. Oncogene 2011 Feb;30(5):548-60
Bordoli MR et al
2011/01/01
Species: Human, Applications: IHC-P PubMed
36 Br旦kers N et al. Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes. Cancer Sci. 2010 Jan;101(1):129-36
Br旦kers N et al
2010/01/01
PubMed
37 Rawluszko AA et al. Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer. BMC Cancer 2013;13:526
Rawluszko AA et al
2013/01/01
PubMed
38 Zhu Q et al. Silencing of HIF prolyl-hydroxylase 2 gene in the renal medulla attenuates salt-sensitive hypertension in Dahl S rats. Am. J. Hypertens. 2014 Jan;27(1):107-13
Zhu Q et al
2014/01/01
PubMed
39 Place TL et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS ONE 2013;8(12):e83021
Place TL et al
2013/01/01
PubMed
40 Sun W et al. Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-&#x3B1;. Cell Death Dis 2014;5:e1322
Sun W et al
2014/01/01
Species: Human, Applications: WB PubMed
41 Lindholm ME et al. Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2014 Aug;307(3):R248-55
Lindholm ME et al
2014/01/01
Species: Human, Applications: WB PubMed
42 Caprara V et al. Endothelin-1 regulates hypoxia-inducible factor-1&#x3B1; and -2&#x3B1; stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells. Life Sci. 2014 Nov;118(2):185-90
Caprara V et al
2014/01/01
Species: Human, Applications: WB PubMed
43 Botting KJ et al. Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes. J Am Heart Assoc 2014 Aug;3(4)
Botting KJ et al
2014/01/01
Applications: WB PubMed
44 Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 2014;5:5582
Henze AT et al
2014/01/01
PubMed
45 Vogler M et al. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015 Jan;
Vogler M et al
2015/01/01
Species: Mouse, Applications: IHC-P PubMed
46 Li J et al. Prolyl-4-hydroxylase Domain Protein 2 Controls NF-&#x3BA;B/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus. J. Biol. Chem. 2015 Mar;290(11):7195-207
Li J et al
2015/01/01
Species: Rat, Applications: ICC/IF PubMed
47 Hsiao HW et al. Deltex1 antagonizes HIF-1&#x3B1; and sustains the stability of regulatory T cells in vivo. Nat Commun 2015;6:6353
Hsiao HW et al
2015/01/01
Species: Human, Mouse, Applications: WB PubMed
48 H旦gel H et al. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol. Cancer 2015;14:143
H旦gel H et al
2015/01/01
Species: Human, Applications: WB PubMed
49 Wu S et al. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1&#x3B1; in a p53-independent manner. Cancer Res. 2013 Mar;73(6):1787-99
Wu S et al
2013/01/01
Species: Human, Applications: WB PubMed
50 Kumar P et al. Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1. PLoS ONE 2015;10(5):e0123725
Kumar P et al
2015/01/01
Species: Human, Primate, Applications: WB, IP PubMed
51 Sun W et al. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4&#x3B1; Expression. Cell. Physiol. Biochem. 2015;37(6):2257-64
Sun W et al
2015/01/01
PubMed
52 Tao Y et al. Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner. Int. J. Biochem. Cell Biol. 2016 Aug;77(Pt A):129-40
Tao Y et al
2016/01/01
PubMed
53 Mysore VS et al. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol. Cancer Res. 2016 Mar;14(3):253-66
Mysore VS et al
2016/01/01
PubMed
54 Fisher A et al. MVPA is associated with lower weight gain in 8-10 year old children: a prospective study with 1 year follow-up. PLoS ONE 2011;6(4):e18576
Fisher A et al
2011/01/01
PubMed
55 Chan DA et al. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 2009 Jun;15(6):527-38
Chan DA et al
2009/01/01
PubMed
56 Kamphues C et al. Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer. Pathobiology 2012;79(1):11-7
Kamphues C et al
2012/01/01
PubMed
57 Ryou MG et al. Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. Neuroscience 2015 Aug;301:193-203
Ryou MG et al
2015/01/01
PubMed
58 Dalgard CL et al. Endogenous 2-oxoacids differentially regulate expression of oxygen sensors. Biochem. J. 2004 Jun;380(Pt 2):419-24
Dalgard CL et al
2004/01/01
PubMed
59 Newpher TM et al. Glutamate receptor dynamics in dendritic microdomains. Neuron 2008 May;58(4):472-97
Newpher TM et al
2008/01/01
PubMed
60 Hemelrijk CK et al. Some causes of the variable shape of flocks of birds. PLoS ONE 2011;6(8):e22479
Hemelrijk CK et al
2011/01/01
PubMed
61 Miles AL et al. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1&#x3B1; prolyl hydroxylation by regulating cellular iron levels. Elife 2017 03;6
Miles AL et al
2017/01/01
Species: Human, Applications: ICC/IF PubMed
62 Burr SP et al. Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1&#x3B1; Stability in Aerobic Conditions. Cell Metab. 2016 11;24(5):740-752
Burr SP et al
2016/01/01
Species: Human, Applications: WB PubMed
63 Zhang Z et al. Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells. Mol Med Rep 2015 Sep;12(3):3809-14
Zhang Z et al
2015/01/01
PubMed
64 Trisciuoglio D et al. Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. PLoS ONE 2010 Jul;5(7):e11772
Trisciuoglio D et al
2010/01/01
Species: Human, Applications: WB PubMed
65 Hu J et al. Hypoxia inducible factor-1&#x3B1; mediates the profibrotic effect of albumin in renal tubular cells. Sci Rep 2017 Nov;7(1):15878
Hu J et al
2017/01/01
Species: Human, Applications: WB PubMed
66 Lam YT et al. Androgen Receptor-Mediated Genomic Androgen Action Augments Ischemia-Induced Neovascularization. Endocrinology 2016 Dec;157(12):4853-4864
Lam YT et al
2016/01/01
PubMed
67 Kim GD et al. CITED2 restrains pro-inflammatory macrophage activation and response. Mol. Cell. Biol. 2017 Dec;
Kim GD et al
2017/01/01
Species: Mouse, Applications: WB PubMed
68 Wottawa M et al. Hypoxia-stimulated membrane trafficking requires T-plastin. Acta Physiol (Oxf) 2017 Sep;221(1):59-73
Wottawa M et al
2017/01/01
PubMed
69 Babosova O et al. Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma&quot;s cyclin D1. J Cell Mol Med 2019 11;23(11):7785-7795
Babosova O et al
2019/01/01
PubMed
70 Settelmeier S et al. Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice. PLoS One 2020;15(5):e0233261
Settelmeier S et al
2020/01/01
PubMed
71 Shi M et al. APC<sup>CDC20</sup>-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma. Cancer Lett 2021 01;496:144-155
Shi M et al
2021/01/01
PubMed
72 Mei H et al. Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats. J Ethnopharmacol 2021 Feb;266:113448
Mei H et al
2021/01/01
PubMed
73 Kumar P et al. Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells. J Cell Biochem 2021 11;122(11):1737-1748
Kumar P et al
2021/01/01
PubMed
  • No.: 1
  • 文献情報:
    Asikainen TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul;102(29):10212-7
    Asikainen TM et al
    2005/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 2
  • 文献情報:
    Jokilehto T et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin. Cancer Res. 2006 Feb;12(4):1080-7
    Jokilehto T et al
    2006/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 3
  • 文献情報:
    Elvidge GP et al. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J. Biol. Chem. 2006 Jun;281(22):15215-26
    Elvidge GP et al
    2006/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 4
  • 文献情報:
    Ietta F et al. Dynamic HIF1A regulation during human placental development. Biol. Reprod. 2006 Jul;75(1):112-21
    Ietta F et al
    2006/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 5
  • 文献情報:
    McMahon S et al. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J. Biol. Chem. 2006 Aug;281(34):24171-81
    McMahon S et al
    2006/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 6
  • 文献情報:
    Barth S et al. The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol. Cell. Biol. 2007 May;27(10):3758-68
    Barth S et al
    2007/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 7
  • 文献情報:
    Weroha SJ et al. Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma. Gynecol. Oncol. 2011 Jul;122(1):116-20
    Weroha SJ et al
    2011/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 8
  • 文献情報:
    Manalo DJ et al. Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1&#x3B1;) and induces hepcidin (Hamp) in rat kidney. Biochem. Biophys. Res. Commun. 2011 Dec;416(3-4):421-6
    Manalo DJ et al
    2011/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 9
  • 文献情報:
    Baek JH et al. Induction of hypoxia inducible factor (HIF-1&#x3B1;) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim. Biophys. Acta ;1809(4-6):262-8
    Baek JH et al
  • 備考:
  • 参照:
    PubMed
  • No.: 10
  • 文献情報:
    Vogel S et al. Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation. J. Biol. Chem. 2010 Oct;285(44):33756-63
    Vogel S et al
    2010/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 11
  • 文献情報:
    Schultz K et al. Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms. Am. J. Physiol. Lung Cell Mol. Physiol. 2009 Jun;296(6):L921-7
    Schultz K et al
    2009/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 12
  • 文献情報:
    Wang Z et al. Hypoxia-inducible factor-1&#x3B1; contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int. 2011 Feb;79(3):300-10
    Wang Z et al
    2011/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 13
  • 文献情報:
    Wollenick K et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012 Mar;40(5):1928-43
    Wollenick K et al
    2012/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 14
  • 文献情報:
    H旦gel H et al. Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells. PLoS ONE 2011;6(11):e27112
    H旦gel H et al
    2011/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 15
  • 文献情報:
    Brockmeier U et al. The function of hypoxia-inducible factor (HIF) is independent of the endoplasmic reticulum protein OS-9. PLoS ONE 2011;6(4):e19151
    Brockmeier U et al
    2011/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 16
  • 文献情報:
    Luo W et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011 May;145(5):732-44
    Luo W et al
    2011/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 17
  • 文献情報:
    Wu YL et al. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J. Cell. Sci. 2006 Jul;119(Pt 13):2797-806
    Wu YL et al
    2006/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 18
  • 文献情報:
    Li N et al. Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys. Am. J. Physiol. Renal Physiol. 2007 Jan;292(1):F207-16
    Li N et al
    2007/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 19
  • 文献情報:
    Yin L et al. Mucin 1 oncoprotein blocks hypoxia-inducible factor 1alpha activation in a survival response to hypoxia. J. Biol. Chem. 2007 Jan;282(1):257-66
    Yin L et al
    2007/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 20
  • 文献情報:
    Rantanen K et al. Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation. Mol. Biol. Cell 2008 May;19(5):2231-40
    Rantanen K et al
    2008/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 21
  • 文献情報:
    Aprelikova O et al. Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res. 2009 Jan;69(2):616-24
    Aprelikova O et al
    2009/01/01
  • 備考:
  • 参照:
    PubMed
  • No.: 22
  • 文献情報:
    Nandal A et al. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab. 2011 Nov;14(5):647-57
    Nandal A et al
    2011/01/01
  • 備考:
    Applications: WB, Species: Human
  • 参照:
    PubMed
  • No.: 23
  • 文献情報:
    Niecknig H et al. Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia. Free Radic. Res. 2012 Jun;46(6):705-17
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    PubMed
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    Fujita N et al. Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1&#x3B1; activity in hypoxia.
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    Verstraete M et al. Investigation of possible endogenous hypoxia markers in colorectal cancer. Int. J. Radiat. Biol. 2012 Aug;
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    PubMed
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    Jokilehto T et al. Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth. Exp. Cell Res. 2010 Apr;316(7):1169-78
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    Persano L et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1&#x3B1; stability and MGMT expression. Cell Death Dis 2012;3:e412
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    De Saedeleer CJ et al. Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells. PLoS ONE 2012;7(10):e46571
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    Han WQ et al. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim. Biophys. Acta 2013 Jun;1833(6):1454-62
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    Kaufmann MR et al. Dysregulation of hypoxia-inducible factor by presenilin/&#x3B3;-secretase loss-of-function mutations. J. Neurosci. 2013 Jan;33(5):1915-26
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    Wottawa M et al. Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-&#x3B2;1 processing. Int. J. Cancer 2013 Jun;132(12):2787-98
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    Luukkaa M et al. Expression of the cellular oxygen sensor PHD2 (EGLN-1) predicts radiation sensitivity in squamous cell cancer of the head and neck. Int. J. Radiat. Biol. 2009;85(10):900-8
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    Tan JT et al. High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1&#x3B1;. FASEB J. 2014 Jan;28(1):206-17
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    Bordoli MR et al. Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis. Oncogene 2011 Feb;30(5):548-60
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    Place TL et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS ONE 2013;8(12):e83021
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    Sun W et al. Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-&#x3B1;. Cell Death Dis 2014;5:e1322
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    Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 2014;5:5582
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    Species: Mouse, Applications: IHC-P
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    Li J et al. Prolyl-4-hydroxylase Domain Protein 2 Controls NF-&#x3BA;B/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus. J. Biol. Chem. 2015 Mar;290(11):7195-207
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    Hsiao HW et al. Deltex1 antagonizes HIF-1&#x3B1; and sustains the stability of regulatory T cells in vivo. Nat Commun 2015;6:6353
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