Anti-HIF-2α, Mouse-Mono(ep190b) <Anti-Hypoxia-Inducible Factor 2α>

データシート

• 商品コード：NB100-132
• メーカー：NOV
• 包装：100μl
• 価格： ¥103,000
• 在庫：1個

マイリストに追加 マイリストに追加済

• No.： 1
• 文献情報：
  Talks KL et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 2000 Aug;157(2):411-21
  Talks KL et al
  2000/01/01
  
• 備考：
  Western Blot and Immunocytochemistry
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• No.： 2
• 文献情報：
  Blancher C et al. Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Cancer Res. 2000 Dec;60(24):7106-13
  Blancher C et al
  2000/01/01
  
• 備考：
  Western Blot and Immunohistochemistry
• 参照：
  

• No.： 3
• 文献情報：
  Koukourakis MI et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res. 2001 Mar;61(5):1830-2
  Koukourakis MI et al
  2001/01/01
  
• 備考：
  Immunohistochemistry
• 参照：
  

• No.： 4
• 文献情報：
  Giatromanolaki A et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001 Nov;61(21):7992-8
  Giatromanolaki A et al
  2001/01/01
  
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• No.： 5
• 文献情報：
  Mohan S et al. von Hippel-Lindau protein complex is regulated by cell density. Oncogene 2003 Aug;22(34):5270-80
  Mohan S et al
  2003/01/01
  
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• No.： 6
• 文献情報：
  Mart鱈n-Puig S et al. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J. Biol. Chem. 2004 Mar;279(10):9504-11
  Mart鱈n-Puig S et al
  2004/01/01
  
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• No.： 7
• 文献情報：
  Pan Y et al. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 2004 Jun;23(29):4975-83
  Pan Y et al
  2004/01/01
  
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• No.： 8
• 文献情報：
  Tissot van Patot MC et al. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 2004 Sep;287(3):L525-32
  Tissot van Patot MC et al
  2004/01/01
  
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• No.： 9
• 文献情報：
  Koike T et al. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc. Natl. Acad. Sci. U.S.A. 2004 May;101(21):8132-7
  Koike T et al
  2004/01/01
  
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• No.： 10
• 文献情報：
  Harvey AJ et al. Oxygen-regulated gene expression in bovine blastocysts. Biol. Reprod. 2004 Oct;71(4):1108-19
  Harvey AJ et al
  2004/01/01
  
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• No.： 11
• 文献情報：
  Mekhail K et al. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat. Cell Biol. 2004 Jul;6(7):642-7
  Mekhail K et al
  2004/01/01
  
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• No.： 12
• 文献情報：
  Rathmell WK et al. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res. 2004 Dec;64(23):8595-603
  Rathmell WK et al
  2004/01/01
  
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• No.： 13
• 文献情報：
  Yoshimura H et al. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin. Cancer Res. 2004 Dec;10(24):8554-60
  Yoshimura H et al
  2004/01/01
  
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• 参照：
  

• No.： 14
• 文献情報：
  Li L et al. Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res. 2005 Aug;65(16):7249-58
  Li L et al
  2005/01/01
  
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• No.： 15
• 文献情報：
  Nakamura E et al. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am. J. Pathol. 2006 Feb;168(2):574-84
  Nakamura E et al
  2006/01/01
  
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• No.： 16
• 文献情報：
  Carroll PA et al. Latent Kaposi&quot;s sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J. Virol. 2006 Nov;80(21):10802-12
  Carroll PA et al
  2006/01/01
  
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• No.： 17
• 文献情報：
  Koizume S et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res. 2006 Oct;66(19):9453-60
  Koizume S et al
  2006/01/01
  
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• 参照：
  

• No.： 18
• 文献情報：
  Yan Q et al. The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Mol. Cell. Biol. 2007 Mar;27(6):2092-102
  Yan Q et al
  2007/01/01
  
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• 参照：
  

• No.： 19
• 文献情報：
  Bernhardt WM et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am. J. Pathol. 2007 Mar;170(3):830-42
  Bernhardt WM et al
  2007/01/01
  
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• 参照：
  

• No.： 20
• 文献情報：
  Sutphin PD et al. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Res. 2007 Jun;67(12):5896-905
  Sutphin PD et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 21
• 文献情報：
  Wiesener MS et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 1998 Oct;92(7):2260-8
  Wiesener MS et al
  1998/01/01
  
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• 参照：
  

• No.： 22
• 文献情報：
  Lee DW et al. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J. Biol. Chem. 2009 Oct;2
  Lee DW et al
  2009/01/01
  
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• 参照：
  

• No.： 23
• 文献情報：
  Munksgaard Persson M et al. HIF-2&#x3B1; expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1&#x3B1; is repressed. Am. J. Pathol. 2012 Feb;180(2):494-504
  Munksgaard Persson M et al
  2012/01/01
  
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• 参照：
  

• No.： 24
• 文献情報：
  Noguera R et al. HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Clin. Cancer Res. 2009 Dec;15(23):7130-6
  Noguera R et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 25
• 文献情報：
  Bohonowych JE et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer 2011;11:520
  Bohonowych JE et al
  2011/01/01
  
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• 参照：
  

• No.： 26
• 文献情報：
  Beasley NJ et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002 May;62(9):2493-7
  Beasley NJ et al
  2002/01/01
  
• 備考：
  
• 参照：
  

• No.： 27
• 文献情報：
  Kao YJ et al. Ligand-dependent mechanisms of sst2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists. Mol. Endocrinol. 2011 Jun;25(6):1040-54
  Kao YJ et al
  2011/01/01
  
• 備考：
  
• 参照：
  

• No.： 28
• 文献情報：
  Conley SJ et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl. Acad. Sci. U.S.A. 2012 Feb;109(8):2784-9
  Conley SJ et al
  2012/01/01
  
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• 参照：
  

• No.： 29
• 文献情報：
  Cartee TV et al. Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism. J. Dermatol. Sci. 2012 Feb;65(2):86-94
  Cartee TV et al
  2012/01/01
  
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• 参照：
  

• No.： 30
• 文献情報：
  Shinojima T et al. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Carcinogenesis 2007 Mar;28(3):529-36
  Shinojima T et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 31
• 文献情報：
  Chintalapudi MR et al. Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis 2008 Apr;29(4):696-703
  Chintalapudi MR et al
  2008/01/01
  
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• 参照：
  

• No.： 32
• 文献情報：
  Ndubuizu OI et al. Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009 Jul;297(1):R158-65
  Ndubuizu OI et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 33
• 文献情報：
  Tuller ER et al. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol. Pharmacol. 2009 Sep;76(
  Tuller ER et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 34
• 文献情報：
  Wacker I et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol. Cell. Biol. 2009 Apr;29(7):1707-18
  Wacker I et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 35
• 文献情報：
  Place TL et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE 2011;6(1):e14617
  Place TL et al
  2011/01/01
  
• 備考：
  
• 参照：
  

• No.： 36
• 文献情報：
  Poey ME et al. Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities. Microb. Pathog. 2012 May;52(5):292-301
  Poey ME et al
  2012/01/01
  
• 備考：
  
• 参照：
  

• No.： 37
• 文献情報：
  Zheng X et al. Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Mol. Cell. Biol. 2006 Jun;26(12):4628-41
  Zheng X et al
  2006/01/01
  
• 備考：
  
• 参照：
  

• No.： 38
• 文献情報：
  Walter A et al. Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. J. Pharmacol. Exp. Ther. 2009 May;329(2):699-707
  Walter A et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 39
• 文献情報：
  Martin SK et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica 2010 May;95(5):776-84
  Martin SK et al
  2010/01/01
  
• 備考：
  
• 参照：
  

• No.： 40
• 文献情報：
  Bangiyeva V et al. Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer 2009;9:229
  Bangiyeva V et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 41
• 文献情報：
  Harvey AJ et al. Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine. Biol. Reprod. 2007 Jul;77(1):93-101
  Harvey AJ et al
  2007/01/01
  
• 備考：
  
• 参照：
  

• No.： 42
• 文献情報：
  Burkitt K et al. Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment. Mol. Cancer Ther. 2009 May;8(5):1148-56
  Burkitt K et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 43
• 文献情報：
  Kim Y et al. Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res. 2009 Dec;69(24):9271-80
  Kim Y et al
  2009/01/01
  
• 備考：
  
• 参照：
  

• No.： 44
• 文献情報：
  Zimmer M et al. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2004 Feb;2(2):89-95
  Zimmer M et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 45
• 文献情報：
  Husted RF et al. Oxygen regulation of the epithelial Na channel in the collecting duct. Am. J. Physiol. Renal Physiol. 2011 Feb;300(2):F412-24
  Husted RF et al
  2011/01/01
  
• 備考：
  
• 参照：
  

• No.： 46
• 文献情報：
  Grabmaier K et al. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 2004 Jul;23(33):5624-31
  Grabmaier K et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 47
• 文献情報：
  Abbruzzetti S et al. Ligand migration through the internal hydrophobic cavities in human neuroglobin. Proc. Natl. Acad. Sci. U.S.A. 2009 Nov;106(45):18984-9
  Abbruzzetti S et al
  2009/01/01
  
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• 参照：
  

• No.： 48
• 文献情報：
  Xia G et al. Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology 2002 May;59(5):774-8
  Xia G et al
  2002/01/01
  
• 備考：
  
• 参照：
  

• No.： 49
• 文献情報：
  Eul B et al. Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia. FASEB J. 2006 Jan;20(1):163-5
  Eul B et al
  2006/01/01
  
• 備考：
  
• 参照：
  

• No.： 50
• 文献情報：
  Kubo T et al. Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours. J Bone Joint Surg Br 2008 Mar;90(3):364-70
  Kubo T et al
  2008/01/01
  
• 備考：
  Applications: WB
• 参照：
  

• No.： 51
• 文献情報：
  Li Q et al. GSK-3&#x3B2;: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Angiogenesis 2011 May;14(2):173-85
  Li Q et al
  2011/01/01
  
• 備考：
  Applications: WB, Species: Mouse
• 参照：
  

• No.： 52
• 文献情報：
  Taylor M et al. Hypoxia-inducible factor-2&#x3B1; mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology 2011 Jun;140(7):2044-55
  Taylor M et al
  2011/01/01
  
• 備考：
  Applications: WB, ChIP, Species: Mouse
• 参照：
  

• No.： 53
• 文献情報：
  Holland WS et al. Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy. Cancer Chemother. Pharmacol. 2012 Jan;69(1):185-94
  Holland WS et al
  2012/01/01
  
• 備考：
  Applications: WB, Species: Human
• 参照：
  

• No.： 54
• 文献情報：
  Jeong CW et al. The Role of Hypoxia-Inducible Factor-1&#x3B1; and -2&#x3B1; in Androgen Insensitive Prostate Cancer Cells. Urol Oncol 2012 Apr;
  Jeong CW et al
  2012/01/01
  
• 備考：
  Applications: WB, Species: Human
• 参照：
  

• No.： 55
• 文献情報：
  JA Walker. EXPRESSION OF HUMAN PAPILLOMAVIRUS TYPE 16 E7 IS SUFFICIENT TO SIGNIFICANTLY INCREASE EXPRESSSION OF ANGIOGENIC FACTORS BUT IS NOT SUFFICIENT TO INDUCE ENDOTHELIAL CELL MIGRATION. Indiana University, in partial fulfillment of the requirements f
  
  
• 備考：
  
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• No.： 56
• 文献情報：
  Lim CS et al. The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent. J. Vasc. Surg. 2012 Oct;56(4):1069-77
  Lim CS et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 57
• 文献情報：
  Muratsu-Ikeda S et al. Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. PLoS ONE 2012;7(7):e41462
  Muratsu-Ikeda S et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 58
• 文献情報：
  Mihaylova S et al. Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats. J Neuroinflammation 2012;9:183
  Mihaylova S et al
  2012/01/01
  
• 備考：
  Species: Rat, Applications: WB
• 参照：
  

• No.： 59
• 文献情報：
  Chen R et al. The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling. J. Biol. Chem. 2012 Aug;287(36):30800-11
  Chen R et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: IP
• 参照：
  

• No.： 60
• 文献情報：
  Heikkil辰 M et al. Roles of the human hypoxia-inducible factor (HIF)-3&#x3B1; variants in the hypoxia response. Cell. Mol. Life Sci. 2011 Dec;68(23):3885-901
  Heikkil辰 M et al
  2011/01/01
  
• 備考：
  Species: Hamster, Applications: WB
• 参照：
  

• No.： 61
• 文献情報：
  Kiss J et al. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J. Immunol. 2012 Aug;189(4):1955-65
  Kiss J et al
  2012/01/01
  
• 備考：
  Species: Mouse, Applications: WB
• 参照：
  

• No.： 62
• 文献情報：
  Lin Q et al. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol. Cancer Res. 2011 Jun;9(6):757-65
  Lin Q et al
  2011/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 63
• 文献情報：
  Chen R et al. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J. Biol. Chem. 2011 Apr;286(16):13869-78
  Chen R et al
  2011/01/01
  
• 備考：
  Applications: WB, ChIP
• 参照：
  

• No.： 64
• 文献情報：
  Vaapil M et al. Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS ONE 2012;7(9):e46543
  Vaapil M et al
  2012/01/01
  
• 備考：
  Applications: IHC, WB
• 参照：
  

• No.： 65
• 文献情報：
  Persano L et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1&#x3B1; stability and MGMT expression. Cell Death Dis 2012;3:e412
  Persano L et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB, ChIP
• 参照：
  

• No.： 66
• 文献情報：
  Xue X et al. Hypoxia-inducible factor-2&#x3B1; is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis 2012 Nov;
  Xue X et al
  2012/01/01
  
• 備考：
  Species: Mouse, Applications: ChIP
• 参照：
  

• No.： 67
• 文献情報：
  Thomas S et al. CD24 Is an Effector of HIF-1-Driven Primary Tumor Growth and Metastasis. Cancer Res. 2012 Nov;72(21):5600-12
  Thomas S et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 68
• 文献情報：
  Demachi-Okamura A et al. Autophagy Creates a CTL Epitope That Mimics Tumor-Associated Antigens. PLoS ONE 2012;7(10):e47126
  Demachi-Okamura A et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 69
• 文献情報：
  Sun HX et al. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology 2013 Mar;57(3):1088-97
  Sun HX et al
  2013/01/01
  
• 備考：
  Species: Human, Applications: ICC/IF
• 参照：
  

• No.： 70
• 文献情報：
  Bougatef F et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. PLoS ONE 2010;5(8):e12265
  Bougatef F et al
  2010/01/01
  
• 備考：
  Species: Human, Applications: WB, ICC/IF, IHC
• 参照：
  

• No.： 71
• 文献情報：
  Huang C et al. Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. PLoS ONE 2012;7(12):e51937
  Huang C et al
  2012/01/01
  
• 備考：
  Species: Mouse, Applications: WB, IHC
• 参照：
  

• No.： 72
• 文献情報：
  El Naggar A et al. Expression and stability of hypoxia inducible factor 1&#x3B1; in osteosarcoma. Pediatr Blood Cancer 2012 Dec;59(7):1215-22
  El Naggar A et al
  2012/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 73
• 文献情報：
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