Anti-HIF-2α, Rabbit-Poly <Anti-Hypoxia-Inducible Factor 2α> <Anti-EPAS1>

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• 商品コード：NB100-122SS
• メーカー：NOV
• 包装：25μl
• 価格： ¥53,000
• 在庫：無(未発注)

マイリストに追加 マイリストに追加済

• No.： 1
• 文献情報：
  Conrad PW et al. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 1999 Nov;274(47):33709-13
  Conrad PW et al
  1999/01/01
  
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• No.： 2
• 文献情報：
  Ohh M et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2000 Jul;2(7):423-7
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  2000/01/01
  
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• No.： 3
• 文献情報：
  Rajakumar A et al. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol. Reprod. 2000 Aug;63(2):559-69
  Rajakumar A et al
  2000/01/01
  
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• No.： 4
• 文献情報：
  Bonicalzi ME et al. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 2001 Jan;276(2):1407-16
  Bonicalzi ME et al
  2001/01/01
  
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• No.： 5
• 文献情報：
  de Paulsen N et al. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2
  de Paulsen N et al
  2001/01/01
  
• 備考：
  flow cytometry, western blot, human
• 参照：
  

• No.： 6
• 文献情報：
  Haase VH et al. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2001 Feb;98(4):1583-8
  Haase VH et al
  2001/01/01
  
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• No.： 7
• 文献情報：
  Alvarez-Tejado M et al. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J. Biol. Chem. 2001 Jun;276(25):22368-74
  Alvarez-Tejado M et al
  2001/01/01
  
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• No.： 8
• 文献情報：
  Luo JC et al. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Oncogene 2001 Mar;20(12):1435-44
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  2001/01/01
  
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• No.： 9
• 文献情報：
  Makino Y et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001 Nov;414(6863):550-4
  Makino Y et al
  2001/01/01
  
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• No.： 10
• 文献情報：
  Minchenko A et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J. Biol. Chem. 2002 Feb;277(8):6183-7
  Minchenko A et al
  2002/01/01
  
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• No.： 11
• 文献情報：
  Burke B et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol. 2002 Feb;196(2):204-12
  Burke B et al
  2002/01/01
  
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• No.： 12
• 文献情報：
  Alvarez-Tejado M et al. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J. Biol. Chem. 2002 Apr;277(16):13508-17
  Alvarez-Tejado M et al
  2002/01/01
  
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• No.： 13
• 文献情報：
  Liang Y et al. Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. J. Biol. Chem. 2002 May;277(22):20087-94
  Liang Y et al
  2002/01/01
  
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• No.： 14
• 文献情報：
  Kondo K et al. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002 Apr;1(3):237-46
  Kondo K et al
  2002/01/01
  
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• 参照：
  

• No.： 15
• 文献情報：
  Maranchie JK et al. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002 Apr;1(3):247-55
  Maranchie JK et al
  2002/01/01
  
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• 参照：
  

• No.： 16
• 文献情報：
  Bernaudin M et al. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J. Biol. Chem. 2002 Oct;277(42):39728-38
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  2002/01/01
  
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• 参照：
  

• No.： 17
• 文献情報：
  Chan DA et al. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem. 2002 Oct;277(42):40112-7
  Chan DA et al
  2002/01/01
  
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• 参照：
  

• No.： 18
• 文献情報：
  Mack FA et al. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 2003 Jan;3(1):75-88
  Mack FA et al
  2003/01/01
  
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• 参照：
  

• No.： 19
• 文献情報：
  Yuan Y et al. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J. Biol. Chem. 2003 May;278(18):15911-6
  Yuan Y et al
  2003/01/01
  
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• 参照：
  

• No.： 20
• 文献情報：
  Del Toro R et al. Induction of T-type calcium channel gene expression by chronic hypoxia. J. Biol. Chem. 2003 Jun;278(25):22316-24
  Del Toro R et al
  2003/01/01
  
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• 参照：
  

• No.： 21
• 文献情報：
  Khatua S et al. Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res. 2003 Apr;63(8):1865-70
  Khatua S et al
  2003/01/01
  
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• 参照：
  

• No.： 22
• 文献情報：
  Mabjeesh NJ et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003 Apr;3(4):363-75
  Mabjeesh NJ et al
  2003/01/01
  
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• 参照：
  

• No.： 23
• 文献情報：
  Baba M et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene 2003 May;22(18):2728-38
  Baba M et al
  2003/01/01
  
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• 参照：
  

• No.： 24
• 文献情報：
  Naranjo-Su叩rez S et al. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J. Biol. Chem. 2003 Aug;278(34):31895-901
  Naranjo-Su叩rez S et al
  2003/01/01
  
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• 参照：
  

• No.： 25
• 文献情報：
  Mohan S et al. von Hippel-Lindau protein complex is regulated by cell density. Oncogene 2003 Aug;22(34):5270-80
  Mohan S et al
  2003/01/01
  
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• 参照：
  

• No.： 26
• 文献情報：
  Staller P et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003 Sep;425(6955):307-11
  Staller P et al
  2003/01/01
  
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• 参照：
  

• No.： 27
• 文献情報：
  del Peso L et al. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 2003 Dec;278(49):48690-5
  del Peso L et al
  2003/01/01
  
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• 参照：
  

• No.： 28
• 文献情報：
  Corn PG et al. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat. Genet. 2003 Nov;35(3):229-37
  Corn PG et al
  2003/01/01
  
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• 参照：
  

• No.： 29
• 文献情報：
  Cuevas Y et al. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res. 2003 Oct;63(20):6877-84
  Cuevas Y et al
  2003/01/01
  
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• 参照：
  

• No.： 30
• 文献情報：
  Mart鱈n-Puig S et al. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J. Biol. Chem. 2004 Mar;279(10):9504-11
  Mart鱈n-Puig S et al
  2004/01/01
  
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• 参照：
  

• No.： 31
• 文献情報：
  Uchida T et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J. Biol. Chem. 2004 Apr;279(15):14871-8
  Uchida T et al
  2004/01/01
  
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• 参照：
  

• No.： 32
• 文献情報：
  Zimmer M et al. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2004 Feb;2(2):89-95
  Zimmer M et al
  2004/01/01
  
• 備考：
  Western blot, ELISA, human/mouse
• 参照：
  

• No.： 33
• 文献情報：
  Mizukami Y et al. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 2004 Mar;64(5):1765-72
  Mizukami Y et al
  2004/01/01
  
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• 参照：
  

• No.： 34
• 文献情報：
  Welsh S et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol. Cancer Ther. 2004 Mar;3(3):233-44
  Welsh S et al
  2004/01/01
  
• 備考：
  
• 参照：
  

• No.： 35
• 文献情報：
  Sato M et al. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am. J. Respir. Cell Mol. Biol. 2004 Aug;31(2):209-15
  Sato M et al
  2004/01/01
  
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• 参照：
  

• No.： 36
• 文献情報：
  Mekhail K et al. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat. Cell Biol. 2004 Jul;6(7):642-7
  Mekhail K et al
  2004/01/01
  
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• 参照：
  

• No.： 37
• 文献情報：
  Grabmaier K et al. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 2004 Jul;23(33):5624-31
  Grabmaier K et al
  2004/01/01
  
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• 参照：
  

• No.： 38
• 文献情報：
  Takeda N et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ. Res. 2004 Jul;95(2):146-53
  Takeda N et al
  2004/01/01
  
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• 参照：
  

• No.： 39
• 文献情報：
  Biju MP et al. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 2004 Oct;24(20):9038-47
  Biju MP et al
  2004/01/01
  
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• 参照：
  

• No.： 40
• 文献情報：
  Freeburg PB et al. Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. J. Am. Soc. Nephrol. 2004 Oct;15(10):2569-78
  Freeburg PB et al
  2004/01/01
  
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• 参照：
  

• No.： 41
• 文献情報：
  Tang N et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004 Nov;6(5):485-95
  Tang N et al
  2004/01/01
  
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• 参照：
  

• No.： 42
• 文献情報：
  Rathmell WK et al. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res. 2004 Dec;64(23):8595-603
  Rathmell WK et al
  2004/01/01
  
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• 参照：
  

• No.： 43
• 文献情報：
  Miller F et al. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J. Biol. Chem. 2005 Mar;280(9):7985-96
  Miller F et al
  2005/01/01
  
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• 参照：
  

• No.： 44
• 文献情報：
  Temes E et al. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J. Biol. Chem. 2005 Jun;280(25):24238-44
  Temes E et al
  2005/01/01
  
• 備考：
  Western blot, human
• 参照：
  

• No.： 45
• 文献情報：
  Asikainen TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul;102(29):10212-7
  Asikainen TM et al
  2005/01/01
  
• 備考：
  Western blot, Human
• 参照：
  

• No.： 46
• 文献情報：
  Kurban G et al. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 2006 Feb;66(3):1313-9
  Kurban G et al
  2006/01/01
  
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• 参照：
  

• No.： 47
• 文献情報：
  Hui AS et al. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006 Mar;20(3):466-75
  Hui AS et al
  2006/01/01
  
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• 参照：
  

• No.： 48
• 文献情報：
  Krishnamachary B et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006 Mar;66(5):2725-31
  Krishnamachary B et al
  2006/01/01
  
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• 参照：
  

• No.： 49
• 文献情報：
  Mizukami Y et al. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J. Biol. Chem. 2006 May;281(20):13957-63
  Mizukami Y et al
  2006/01/01
  
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• 参照：
  

• No.： 50
• 文献情報：
  Ietta F et al. Dynamic HIF1A regulation during human placental development. Biol. Reprod. 2006 Jul;75(1):112-21
  Ietta F et al
  2006/01/01
  
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• 参照：
  

• No.： 51
• 文献情報：
  Hu CJ et al. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol. Cell. Biol. 2006 May;26(9):3514-26
  Hu CJ et al
  2006/01/01
  
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• 参照：
  

• No.： 52
• 文献情報：
  Nakamura K et al. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006 Apr;66(8):4249-55
  Nakamura K et al
  2006/01/01
  
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• 参照：
  

• No.： 53
• 文献情報：
  Bracken CP et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J. Biol. Chem. 2006 Aug;281(32):22575-85
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  2006/01/01
  
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• 参照：
  

• No.： 54
• 文献情報：
  Hergovich A et al. Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Mol. Cell. Biol. 2006 Aug;26(15):5784-96
  Hergovich A et al
  2006/01/01
  
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• 参照：
  

• No.： 55
• 文献情報：
  Lutz MS et al. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res. 2006 Jul;66(14):6903-7
  Lutz MS et al
  2006/01/01
  
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• 参照：
  

• No.： 56
• 文献情報：
  Franovic A et al. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res. 2006 Aug;66(16):8083-90
  Franovic A et al
  2006/01/01
  
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• No.： 57
• 文献情報：
  Shinojima T et al. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Carcinogenesis 2007 Mar;28(3):529-36
  Shinojima T et al
  2007/01/01
  
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• No.： 58
• 文献情報：
  Lin Q et al. Differentiation arrest by hypoxia. J. Biol. Chem. 2006 Oct;281(41):30678-83
  Lin Q et al
  2006/01/01
  
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• No.： 59
• 文献情報：
  Carroll PA et al. Latent Kaposi&#39;s sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J. Virol. 2006 Nov;80(21):10802-12
  Carroll PA et al
  2006/01/01
  
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• No.： 60
• 文献情報：
  Chavez JC et al. The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J. Neurosci. 2006 Sep;26(37):9471-81
  Chavez JC et al
  2006/01/01
  
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• No.： 61
• 文献情報：
  Koizume S et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res. 2006 Oct;66(19):9453-60
  Koizume S et al
  2006/01/01
  
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• 参照：
  

• No.： 62
• 文献情報：
  Evans AJ et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol. Cell. Biol. 2007 Jan;27(1):157-69
  Evans AJ et al
  2007/01/01
  
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• 参照：
  

• No.： 63
• 文献情報：
  Block K et al. NAD(P)H oxidases regulate HIF-2alpha protein expression. J. Biol. Chem. 2007 Mar;282(11):8019-26
  Block K et al
  2007/01/01
  
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• No.： 64
• 文献情報：
  Gruber M et al. Acute postnatal ablation of Hif-2alpha results in anemia. Proc. Natl. Acad. Sci. U.S.A. 2007 Feb;104(7):2301-6
  Gruber M et al
  2007/01/01
  
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• No.： 65
• 文献情報：
  MacKenzie ED et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 2007 May;27(9):3282-9
  MacKenzie ED et al
  2007/01/01
  
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• No.： 66
• 文献情報：
  Yoo S et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015 Jan;11(1):e1004898
  Yoo S et al
  2015/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 67
• 文献情報：
  Mangiavini L et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev. Biol. 2014 Sep;393(1):124-36
  Mangiavini L et al
  2014/01/01
  
• 備考：
  Species: Mouse, Applications: IHC-P
• 参照：
  

• No.： 68
• 文献情報：
  Slominski A et al. The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1&#x3B1; expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014 Dec;563:79-93
  Slominski A et al
  2014/01/01
  
• 備考：
  Species: Human, Hamster, Applications: WB
• 参照：
  

• No.： 69
• 文献情報：
  Bordji K et al. Hypoxia-inducible factor-2&#x3B1; (HIF-2&#x3B1;), but not HIF-1&#x3B1;, is essential for hypoxic induction of class III &#x3B2;-tubulin expression in human glioblastoma cells. FEBS J. 2014 Dec;281(23):5220-36
  Bordji K et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB, GS
• 参照：
  

• No.： 70
• 文献情報：
  Koh MY et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015 Jan;75(2):316-29
  Koh MY et al
  2015/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 71
• 文献情報：
  Neelam S et al. Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3&#x3B2;, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol. Vis. 2014;20:1758-75
  Neelam S et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB
• 参照：
  

• No.： 72
• 文献情報：
  Liu XD et al. Autophagy mediates HIF2&#x3B1; degradation and suppresses renal tumorigenesis. Oncogene 2014 Jul;
  Liu XD et al
  2014/01/01
  
• 備考：
  Species: Human, Applications: WB, IP, Co-IP
• 参照：
  

• No.： 73
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  El Assar M et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1&#x3B1; activation. Br. J. Pharmacol. 2014 Nov;
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  Zhu J et al. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2&#x3B1; at the CYP51 promoter. J. Lipid Res. 2014 Mar;55(3):431-42
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  Palayoor ST et al. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin. Cancer Res. 2003 Aug;9(8):3150-7
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  Nayak BK et al. Stabilization of HIF-2&#x3B1; through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene 2012 Aug;
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  Zhou Y et al. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am. J. Pathol. 2014 Dec;184(12):3321-31
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