価格表
在庫・価格 ： 2024年05月01日 14時53分 現在
| 商品名 | 商品コード | メーカー | 包装 | 価格 | 在庫 | リスト |
|---|---|---|---|---|---|---|
|
Anti-HIF-2α, Rabbit-Poly <Anti-Hypoxia-Inducible Factor 2α> <Anti-EPAS1> データシート |
NB100-122 |
NOVノバス バイオロジカルス Novus biologicals, LLC |
100 μl | ¥103,000 | 1個 | 追加 |
在庫・価格 ： 2024年05月01日 14時53分 現在
使用文献
| No. | 文献情報 | 備考 | 参照 |
|---|---|---|---|
| 1 |
Conrad PW et al. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 1999 Nov;274(47):33709-13 Conrad PW et al 1999/01/01 |
 |
|
| 2 |
Ohh M et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2000 Jul;2(7):423-7 Ohh M et al 2000/01/01 |
|
|
| 3 |
Rajakumar A et al. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol. Reprod. 2000 Aug;63(2):559-69 Rajakumar A et al 2000/01/01 |
|
|
| 4 |
Bonicalzi ME et al. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 2001 Jan;276(2):1407-16 Bonicalzi ME et al 2001/01/01 |
|
|
| 5 |
de Paulsen N et al. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2 de Paulsen N et al 2001/01/01 |
flow cytometry, western blot, human | |
| 6 |
Haase VH et al. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2001 Feb;98(4):1583-8 Haase VH et al 2001/01/01 |
|
|
| 7 |
Alvarez-Tejado M et al. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J. Biol. Chem. 2001 Jun;276(25):22368-74 Alvarez-Tejado M et al 2001/01/01 |
|
|
| 8 |
Luo JC et al. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Oncogene 2001 Mar;20(12):1435-44 Luo JC et al 2001/01/01 |
|
|
| 9 |
Makino Y et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001 Nov;414(6863):550-4 Makino Y et al 2001/01/01 |
|
|
| 10 |
Minchenko A et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J. Biol. Chem. 2002 Feb;277(8):6183-7 Minchenko A et al 2002/01/01 |
|
|
| 11 |
Burke B et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol. 2002 Feb;196(2):204-12 Burke B et al 2002/01/01 |
|
|
| 12 |
Alvarez-Tejado M et al. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J. Biol. Chem. 2002 Apr;277(16):13508-17 Alvarez-Tejado M et al 2002/01/01 |
|
|
| 13 |
Liang Y et al. Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. J. Biol. Chem. 2002 May;277(22):20087-94 Liang Y et al 2002/01/01 |
|
|
| 14 |
Kondo K et al. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002 Apr;1(3):237-46 Kondo K et al 2002/01/01 |
|
|
| 15 |
Maranchie JK et al. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002 Apr;1(3):247-55 Maranchie JK et al 2002/01/01 |
|
|
| 16 |
Bernaudin M et al. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J. Biol. Chem. 2002 Oct;277(42):39728-38 Bernaudin M et al 2002/01/01 |
|
|
| 17 |
Chan DA et al. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem. 2002 Oct;277(42):40112-7 Chan DA et al 2002/01/01 |
|
|
| 18 |
Mack FA et al. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 2003 Jan;3(1):75-88 Mack FA et al 2003/01/01 |
|
|
| 19 |
Yuan Y et al. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J. Biol. Chem. 2003 May;278(18):15911-6 Yuan Y et al 2003/01/01 |
|
|
| 20 |
Del Toro R et al. Induction of T-type calcium channel gene expression by chronic hypoxia. J. Biol. Chem. 2003 Jun;278(25):22316-24 Del Toro R et al 2003/01/01 |
|
|
| 21 |
Khatua S et al. Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res. 2003 Apr;63(8):1865-70 Khatua S et al 2003/01/01 |
|
|
| 22 |
Mabjeesh NJ et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003 Apr;3(4):363-75 Mabjeesh NJ et al 2003/01/01 |
|
|
| 23 |
Baba M et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene 2003 May;22(18):2728-38 Baba M et al 2003/01/01 |
|
|
| 24 |
Naranjo-Su叩rez S et al. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J. Biol. Chem. 2003 Aug;278(34):31895-901 Naranjo-Su叩rez S et al 2003/01/01 |
|
|
| 25 |
Park SK et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 2003 Jul;23(14):4959-71 Park SK et al 2003/01/01 |
|
|
| 26 |
Mabjeesh NJ et al. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3"-kinase/protein kinase B in prostate cancer cells. Clin. Cancer Res. 2003 Jul;9(7):2416-25 Mabjeesh NJ et al 2003/01/01 |
|
|
| 27 |
Palayoor ST et al. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin. Cancer Res. 2003 Aug;9(8):3150-7 Palayoor ST et al 2003/01/01 |
|
|
| 28 |
Mohan S et al. von Hippel-Lindau protein complex is regulated by cell density. Oncogene 2003 Aug;22(34):5270-80 Mohan S et al 2003/01/01 |
|
|
| 29 |
Staller P et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003 Sep;425(6955):307-11 Staller P et al 2003/01/01 |
|
|
| 30 |
del Peso L et al. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 2003 Dec;278(49):48690-5 del Peso L et al 2003/01/01 |
|
|
| 31 |
Corn PG et al. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat. Genet. 2003 Nov;35(3):229-37 Corn PG et al 2003/01/01 |
|
|
| 32 |
Cuevas Y et al. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res. 2003 Oct;63(20):6877-84 Cuevas Y et al 2003/01/01 |
|
|
| 33 |
Mart鱈n-Puig S et al. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J. Biol. Chem. 2004 Mar;279(10):9504-11 Mart鱈n-Puig S et al 2004/01/01 |
|
|
| 34 |
Uchida T et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J. Biol. Chem. 2004 Apr;279(15):14871-8 Uchida T et al 2004/01/01 |
|
|
| 35 |
Zimmer M et al. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2004 Feb;2(2):89-95 Zimmer M et al 2004/01/01 |
Western blot, ELISA, human/mouse | |
| 36 |
Mizukami Y et al. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 2004 Mar;64(5):1765-72 Mizukami Y et al 2004/01/01 |
|
|
| 37 |
Welsh S et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol. Cancer Ther. 2004 Mar;3(3):233-44 Welsh S et al 2004/01/01 |
|
|
| 38 |
Sato M et al. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am. J. Respir. Cell Mol. Biol. 2004 Aug;31(2):209-15 Sato M et al 2004/01/01 |
|
|
| 39 |
Mekhail K et al. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat. Cell Biol. 2004 Jul;6(7):642-7 Mekhail K et al 2004/01/01 |
|
|
| 40 |
Grabmaier K et al. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 2004 Jul;23(33):5624-31 Grabmaier K et al 2004/01/01 |
|
|
| 41 |
Takeda N et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ. Res. 2004 Jul;95(2):146-53 Takeda N et al 2004/01/01 |
|
|
| 42 |
Biju MP et al. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 2004 Oct;24(20):9038-47 Biju MP et al 2004/01/01 |
|
|
| 43 |
Freeburg PB et al. Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. J. Am. Soc. Nephrol. 2004 Oct;15(10):2569-78 Freeburg PB et al 2004/01/01 |
|
|
| 44 |
Tang N et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004 Nov;6(5):485-95 Tang N et al 2004/01/01 |
Western Blot, Mouse | |
| 45 |
Rathmell WK et al. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res. 2004 Dec;64(23):8595-603 Rathmell WK et al 2004/01/01 |
|
|
| 46 |
Miller F et al. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J. Biol. Chem. 2005 Mar;280(9):7985-96 Miller F et al 2005/01/01 |
|
|
| 47 |
Temes E et al. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J. Biol. Chem. 2005 Jun;280(25):24238-44 Temes E et al 2005/01/01 |
Western blot, human | |
| 48 |
Asikainen TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul;102(29):10212-7 Asikainen TM et al 2005/01/01 |
Western blot, human | |
| 49 |
Calvani M et al. Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 2006 Apr;107(7):2705-12 Calvani M et al 2006/01/01 |
|
|
| 50 |
Schultz K et al. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 2006 Jun;290(6):H2528-34 Schultz K et al 2006/01/01 |
|
|
| 51 |
Kurban G et al. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 2006 Feb;66(3):1313-9 Kurban G et al 2006/01/01 |
|
|
| 52 |
Hui AS et al. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006 Mar;20(3):466-75 Hui AS et al 2006/01/01 |
|
|
| 53 |
Krishnamachary B et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006 Mar;66(5):2725-31 Krishnamachary B et al 2006/01/01 |
|
|
| 54 |
Mizukami Y et al. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J. Biol. Chem. 2006 May;281(20):13957-63 Mizukami Y et al 2006/01/01 |
|
|
| 55 |
Okuyama H et al. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J. Biol. Chem. 2006 Jun;281(22):15554-63 Okuyama H et al 2006/01/01 |
|
|
| 56 |
Ietta F et al. Dynamic HIF1A regulation during human placental development. Biol. Reprod. 2006 Jul;75(1):112-21 Ietta F et al 2006/01/01 |
|
|
| 57 |
Hu CJ et al. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol. Cell. Biol. 2006 May;26(9):3514-26 Hu CJ et al 2006/01/01 |
|
|
| 58 |
Nakamura K et al. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006 Apr;66(8):4249-55 Nakamura K et al 2006/01/01 |
|
|
| 59 |
Bracken CP et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J. Biol. Chem. 2006 Aug;281(32):22575-85 Bracken CP et al 2006/01/01 |
|
|
| 60 |
Hergovich A et al. Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Mol. Cell. Biol. 2006 Aug;26(15):5784-96 Hergovich A et al 2006/01/01 |
|
|
| 61 |
Lutz MS et al. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res. 2006 Jul;66(14):6903-7 Lutz MS et al 2006/01/01 |
|
|
| 62 |
Franovic A et al. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res. 2006 Aug;66(16):8083-90 Franovic A et al 2006/01/01 |
|
|
| 63 |
Shinojima T et al. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Carcinogenesis 2007 Mar;28(3):529-36 Shinojima T et al 2007/01/01 |
|
|
| 64 |
Lin Q et al. Differentiation arrest by hypoxia. J. Biol. Chem. 2006 Oct;281(41):30678-83 Lin Q et al 2006/01/01 |
|
|
| 65 |
Carroll PA et al. Latent Kaposi"s sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J. Virol. 2006 Nov;80(21):10802-12 Carroll PA et al 2006/01/01 |
|
|
| 66 |
Takeda K et al. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol. 2006 Nov;26(22):8336-46 Takeda K et al 2006/01/01 |
|
|
| 67 |
Chavez JC et al. The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J. Neurosci. 2006 Sep;26(37):9471-81 Chavez JC et al 2006/01/01 |
|
|
| 68 |
Koizume S et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res. 2006 Oct;66(19):9453-60 Koizume S et al 2006/01/01 |
|
|
| 69 |
Evans AJ et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol. Cell. Biol. 2007 Jan;27(1):157-69 Evans AJ et al 2007/01/01 |
|
|
| 70 |
Block K et al. NAD(P)H oxidases regulate HIF-2alpha protein expression. J. Biol. Chem. 2007 Mar;282(11):8019-26 Block K et al 2007/01/01 |
|
|
| 71 |
Gruber M et al. Acute postnatal ablation of Hif-2alpha results in anemia. Proc. Natl. Acad. Sci. U.S.A. 2007 Feb;104(7):2301-6 Gruber M et al 2007/01/01 |
|
|
| 72 |
MacKenzie ED et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 2007 May;27(9):3282-9 MacKenzie ED et al 2007/01/01 |
|
|
| 73 |
Nagano M et al. Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood 2007 Jul;110(1):151-60 Nagano M et al 2007/01/01 |
|
|
| 74 |
Zhang H et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007 May;11(5):407-20 Zhang H et al 2007/01/01 |
|
|
| 75 |
Milkiewicz M et al. HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J. Physiol. (Lond.) 2007 Sep;583(Pt 2):753-66 Milkiewicz M et al 2007/01/01 |
|
|
| 76 |
Cheng G et al. Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Nov;293(5):L1339-47 Cheng G et al 2007/01/01 |
|
|
| 77 |
Minamishima YA et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 2008 Mar;111(6):3236-44 Minamishima YA et al 2008/01/01 |
|
|
| 78 |
Lomb DJ et al. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of s Lomb DJ et al 2009/01/01 |
|
|
| 79 |
Rankin EB et al. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell 2012 Mar;149(1):63-74 Rankin EB et al 2012/01/01 |
|
|
| 80 |
Rey S et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc. Natl. Acad. Sci. U.S.A. 2009 Dec;106(48):20399-404 Rey S et al 2009/01/01 |
|
|
| 81 |
Koivunen P et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 2012 Mar;483(7390):484-8 Koivunen P et al 2012/01/01 |
|
|
| 82 |
Higashimura Y et al. Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. Biochem. Biophys. Res. Commun. 2011 Sep;413(2):201-5 Higashimura Y et al 2011/01/01 |
|
|
| 83 |
Tuller ER et al. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol. Pharmacol. 2009 Sep;76( Tuller ER et al 2009/01/01 |
|
|
| 84 |
Singh M et al. Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta. Gynecol. Oncol. 2011 Jul;122(1):178-82 Singh M et al 2011/01/01 |
|
|
| 85 |
Wiese M et al. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect. Immun. 2012 Apr;80(4):1455-66 Wiese M et al 2012/01/01 |
|
|
| 86 |
Farrow EG et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc. Natl. Acad. Sci. U.S.A. 2011 Nov;108(46):E1146-55 Farrow EG et al 2011/01/01 |
|
|
| 87 |
Luo W et al. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J. Biol. Chem. 2010 Feb;285(6):3651-63 Luo W et al 2010/01/01 |
|
|
| 88 |
Peng YJ et al. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc. Natl. Acad. Sci. U.S.A. 2011 Feb;108(7):3065-70 Peng YJ et al 2011/01/01 |
|
|
| 89 |
Tsui AK et al. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc. Natl. Acad. Sci. U.S.A. 2011 Oct;108(42):17544-9 Tsui AK et al 2011/01/01 |
|
|
| 90 |
Puppo M et al. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol. Cancer Ther. 2008 Jul;7(7):1974-84 Puppo M et al 2008/01/01 |
|
|
| 91 |
Bohonowych JE et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer 2011;11:520 Bohonowych JE et al 2011/01/01 |
|
|
| 92 |
Hu Z et al. Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2010 Nov;299(5):C930-8 Hu Z et al 2010/01/01 |
|
|
| 93 |
Gabai VL et al. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol. Cell. Biol. 2012 Mar;32(5):929-40 Gabai VL et al 2012/01/01 |
|
|
| 94 |
Kuzmanov A et al. Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Int. J. Cancer 2012 Sep;131(5):E603-13 Kuzmanov A et al 2012/01/01 |
|
|
| 95 |
Xu Y et al. Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Arch. Toxicol. 2012 Jun;86(6):947-59 Xu Y et al 2012/01/01 |
|
|
| 96 |
Conley SJ et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl. Acad. Sci. U.S.A. 2012 Feb;109(8):2784-9 Conley SJ et al 2012/01/01 |
|
|
| 97 |
Koh MY et al. The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 2011 Jun;71(11):4015-27 Koh MY et al 2011/01/01 |
|
|
| 98 |
Grover TR et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Jun;292(6):L1345-51 Grover TR et al 2007/01/01 |
|
|
| 99 |
Yu B et al. Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model. J. Mol. Med. 2012 Aug;90(8):971-81 Yu B et al 2012/01/01 |
|
|
| 100 |
Bussolati B et al. Hypoxia modulates the undifferentiated phenotype of human renal inner medullary CD133+ progenitors through Oct4/miR-145 balance. Am. J. Physiol. Renal Physiol. 2012 Jan;302(1):F116-28 Bussolati B et al 2012/01/01 |
|
|
| 101 |
Biernat S. [Fibroxanthoma retroperitonei]. Wiad. Lek. 1976 May;29(9):845-8 Biernat S 1976/01/01 |
|
|
| 102 |
Hansen SL et al. Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. J. Nutr. 2009 Aug;139(8):1474-9 Hansen SL et al 2009/01/01 |
|
|
| 103 |
Brown ST et al. Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2α: role in modulating secretion. Biochem. Biophys. Res. Commun. 2011 Sep;412(3):466-72 Brown ST et al 2011/01/01 |
|
|
| 104 |
Lange C et al. Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest. Ophthalmol. Vis. Sci. 2011 Jul;52(8):5872-80 Lange C et al 2011/01/01 |
|
|
| 105 |
Copple BL et al. Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Liver Int. 2011 Feb;31(2):230-44 Copple BL et al 2011/01/01 |
|
|
| 106 |
Koh MY et al. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol. Cell. Biol. 2008 Dec;28(23):7081-95 Koh MY et al 2008/01/01 |
|
|
| 107 |
Yamashita T et al. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood 2008 Aug;112(4):1482-92 Yamashita T et al 2008/01/01 |
|
|
| 108 |
Meyuhas R et al. A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Mol. Cancer Res. 2008 Sep;6(9):1397-409 Meyuhas R et al 2008/01/01 |
|
|
| 109 |
Ginouv竪s A et al. PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc. Natl. Acad. Sci. U.S.A. 2008 Mar;105(12):4745-50 Ginouv竪s A et al 2008/01/01 |
|
|
| 110 |
Lee K et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. U.S.A. 2009 Feb;106(7):2353-8 Lee K et al 2009/01/01 |
|
|
| 111 |
Arab A et al. Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity. J. Pharmacol. Exp. Ther. 2008 May;325(2):417-24 Arab A et al 2008/01/01 |
|
|
| 112 |
Lee K A et al. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol. Cancer Res. 2008 May;6(5):829-42 Lee K A et al 2008/01/01 |
|
|
| 113 |
Xie L et al. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2011 Jun;300(6):C1298-305 Xie L et al 2011/01/01 |
|
|
| 114 |
Sch旦del J et al. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am. J. Pathol. 2009 May;174(5):1663-74 Sch旦del J et al 2009/01/01 |
|
|
| 115 |
Lu CW et al. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J. Biol. Chem. 2008 Oct;283(42):28106-14 Lu CW et al 2008/01/01 |
|
|
| 116 |
Brown ST et al. Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am. J. Physiol., Cell Physiol. 2008 Jun;294(6):C1305-12 Brown ST et al 2008/01/01 |
|
|
| 117 |
Walter A et al. Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. J. Pharmacol. Exp. Ther. 2009 May;329(2):699-707 Walter A et al 2009/01/01 |
|
|
| 118 |
Martin SK et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica 2010 May;95(5):776-84 Martin SK et al 2010/01/01 |
|
|
| 119 |
Fang HY et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009 Jul;114(4):844-59 Fang HY et al 2009/01/01 |
|
|
| 120 |
Henze AT et al. Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res. 2010 Jan;70(1):357-66 Henze AT et al 2010/01/01 |
|
|
| 121 |
Xu J et al. Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element. Oncogene 2012 Feb;31(8):1065-72 Xu J et al 2012/01/01 |
|
|
| 122 |
Lange C et al. Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision. Neurobiol. Dis. 2011 Jan;41(1):119-30 Lange C et al 2011/01/01 |
|
|
| 123 |
Ryu JH et al. Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ. 2012 Mar;19(3):440-50 Ryu JH et al 2012/01/01 |
|
|
| 124 |
Sakoda Y et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J. Clin. Invest. 2011 Dec;121(12):4810-9 Sakoda Y et al 2011/01/01 |
|
|
| 125 |
Hughes MD et al. HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer Cell Int. 2007;7:13 Hughes MD et al 2007/01/01 |
|
|
| 126 |
Wacker I et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol. Cell. Biol. 2009 Apr;29(7):1707-18 Wacker I et al 2009/01/01 |
|
|
| 127 |
Krieg AJ et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol. Cell. Biol. 2010 Jan;30(1):344-53 Krieg AJ et al 2010/01/01 |
|
|
| 128 |
van Hagen M et al. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res. 2010 Apr;38(6):1922-31 van Hagen M et al 2010/01/01 |
|
|
| 129 |
Zhou W et al. Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS ONE 2011;6(11):e27460 Zhou W et al 2011/01/01 |
|
|
| 130 |
Hubbi ME et al. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J. Biol. Chem. 2012 Feb;287(9):6139-49 Hubbi ME et al 2012/01/01 |
|
|
| 131 |
Zhang H et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec;105(50):19579-86 Zhang H et al 2008/01/01 |
|
|
| 132 |
Kojima I et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J. Am. Soc. Nephrol. 2007 Apr;18(4):1218-26 Kojima I et al 2007/01/01 |
|
|
| 133 |
Place TL et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE 2011;6(1):e14617 Place TL et al 2011/01/01 |
|
|
| 134 |
Trollmann R et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008 Dec;295(6):R1973-81 Trollmann R et al 2008/01/01 |
|
|
| 135 |
Sears JE et al. Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec;105(50):19898-903 Sears JE et al 2008/01/01 |
|
|
| 136 |
Mahajan S et al. Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis 2008 Sep;29(9):1734-41 Mahajan S et al 2008/01/01 |
|
|
| 137 |
Shen GM et al. Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. Biochem. J. 2012 Jan;441(2):675-83 Shen GM et al 2012/01/01 |
|
|
| 138 |
Dutta D et al. Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. J. Biol. Chem. 2008 Sep;283(37):25404-13 Dutta D et al 2008/01/01 |
|
|
| 139 |
Chen C et al. Association of elevated HIF-2α levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma. Ann. Surg. Oncol. 2011 Aug;18(8):2364-72 Chen C et al 2011/01/01 |
|
|
| 140 |
Zhang H et al. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011 Jul;9(7):e1001112 Zhang H et al 2011/01/01 |
|
|
| 141 |
Luu VD et al. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin. Cancer Res. 2009 May;15(10):3297-304 Luu VD et al 2009/01/01 |
|
|
| 142 |
Bruning U et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol. Cell. Biol. 2011 Oct;31(19):4087-96 Bruning U et al 2011/01/01 |
|
|
| 143 |
Graven KK et al. HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Biochim. Biophys. Acta 2003 Apr;1626(1-3):10-8 Graven KK et al 2003/01/01 |
|
|
| 144 |
Metallo CM et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012 Jan;481(7381):380-4 Metallo CM et al 2012/01/01 |
|
|
| 145 |
Franovic A et al. Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl. Acad. Sci. U.S.A. 2009 Dec;106(50):21306-11 Franovic A et al 2009/01/01 |
|
|
| 146 |
Smith K et al. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005 Jun;65(12):5221-30 Smith K et al 2005/01/01 |
|
|
| 147 |
Lee K et al. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc. Natl. Acad. Sci. U.S.A. 2009 Oct;106(42):17910-5 Lee K et al 2009/01/01 |
|
|
| 148 |
Wang H et al. Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells. Mutat. Res. 2011 Aug;723(2):171-6 Wang H et al 2011/01/01 |
|
|
| 149 |
Ad N et al. Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ann. Thorac. Surg. 2001 Sep;72(3):688-93 Ad N et al 2001/01/01 |
|
|
| 150 |
Takeda K et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 2008 Mar;111(6):3229-35 Takeda K et al 2008/01/01 |
|
|
| 151 |
Minamishima YA et al. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol. Cell. Biol. 2009 Nov;29(21):5729-41 Minamishima YA et al 2009/01/01 |
|
|
| 152 |
Kanno T et al. JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Oncogene 2012 Jun;31(25):3098-110 Kanno T et al 2012/01/01 |
|
|
| 153 |
Luo W et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011 May;145(5):732-44 Luo W et al 2011/01/01 |
|
|
| 154 |
Matak P et al. Lack of iron-related phenotype in Sp6 intestinal knockout mice. Blood Cells Mol. Dis. 2011 Jun;47(1):46-9 Matak P et al 2011/01/01 |
|
|
| 155 |
Zhou G et al. Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J. 2008 May;22(5):1335-42 Zhou G et al 2008/01/01 |
|
|
| 156 |
Kim J et al. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology 2009 Jul;150(7):3392-400 Kim J et al 2009/01/01 |
|
|
| 157 |
Ma Y et al. Prostate cancer cell lines under hypoxia exhibit greater stem-like properties. PLoS ONE 2011;6(12):e29170 Ma Y et al 2011/01/01 |
|
|
| 158 |
Regazzetti C et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 2009 Jan;58(1):95-103 Regazzetti C et al 2009/01/01 |
|
|
| 159 |
Nagao K et al. HIF-2 directly activates CD82 gene expression in endothelial cells. Biochem. Biophys. Res. Commun. 2011 Apr;407(1):260-5 Nagao K et al 2011/01/01 |
|
|
| 160 |
Neal CS et al. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med 2010;8:64 Neal CS et al 2010/01/01 |
|
|
| 161 |
Pan Y et al. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 2004 Jun;23(29):4975-83 Pan Y et al 2004/01/01 |
|
|
| 162 |
Korgaonkar SN et al. HIV-1 upregulates VEGF in podocytes. J. Am. Soc. Nephrol. 2008 May;19(5):877-83 Korgaonkar SN et al 2008/01/01 |
|
|
| 163 |
Xia G et al. Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology 2002 May;59(5):774-8 Xia G et al 2002/01/01 |
|
|
| 164 |
Ren H et al. A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α. Invest. Ophthalmol. Vis. Sci. 2011 May;52(6):3112-8 Ren H et al 2011/01/01 |
Applications: WB, Species: Mouse | |
| 165 |
Valsecchi V et al. NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke 2011 Mar;42(3):754-63 Valsecchi V et al 2011/01/01 |
Applications: WB, Species: Human | |
| 166 |
Poitz DM et al. OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway. Basic Res. Cardiol. 2011 Sep;106(5):761-72 Poitz DM et al 2011/01/01 |
Applications: WB, Species: Human | |
| 167 |
Heddleston JM et al. Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ. 2012 Mar;19(3):428-39 Heddleston JM et al 2012/01/01 |
Applications: WB, Species: Human | |
| 168 |
Zhang H et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012 Apr;31(14):1757-70 Zhang H et al 2012/01/01 |
Applications: WB, Species: Human | |
| 169 |
Schrobback K et al. Effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Eng Part A 2012 May;18(9-10):920-33 Schrobback K et al 2012/01/01 |
Applications: IHC-Fr, IF, Species: Human | |
| 170 |
Ding Z et al. Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. J Biomol Screen 2012 Jun;17(5):572-80 Ding Z et al 2012/01/01 |
Applications: WB, Species: Human | |
| 171 |
Salman S et al. Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Am. J. Physiol., Cell Physiol. 2012 May;302(10):C1531-8 Salman S et al 2012/01/01 |
Applications: WB, Species: Rat | |
| 172 |
Xu Y et al. EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells. PLoS ONE 2012;7(5):e37765 Xu Y et al 2012/01/01 |
Applications: WB, Species: Human | |
| 173 |
Zhou Q et al. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization. FEBS Lett. 2012 May;586(10):1510-5 Zhou Q et al 2012/01/01 |
Applications: WB, Species: Human | |
| 174 |
Uniacke J et al. An oxygen-regulated switch in the protein synthesis machinery. Nature 2012 Jun;486(7401):126-9 Uniacke J et al 2012/01/01 |
Applications: WB, Species: Human | |
| 175 |
Park SJ et al. L-2-Oxothiazolidine-4-Carboxylic Acid or α-Lipoic Acid Attenuates Airway Remodeling: Involvement of Nuclear Factor-κB (NF-κB), Nuclear Factor Erythroid 2p45-Related Factor-2 (Nrf2), and Hypoxia-Inducible Factor (HIF). Int Park SJ et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 176 |
Chintala S et al. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. BMC Cancer 2012;12:293 Chintala S et al 2012/01/01 |
Species: Human, Applications: WB | |
| 177 |
Park SJ et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm. Res. 2012 Oct;61(10):1069-83 Park SJ et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 178 |
Bardella C et al. Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Mol. Cell. Biol. 2012 Aug;32(15):3081-94 Bardella C et al 2012/01/01 |
Species: Human, Applications: WB | |
| 179 |
Lee SW et al. Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Mol Med 2012 Sep;4(9):924-38 Lee SW et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 180 |
Jham BC et al. Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi"s sarcoma. PLoS ONE 2011;6(4):e19103 Jham BC et al 2011/01/01 |
Species: Mouse, Human, Applications: IHC, WB | |
| 181 |
Pourvali K et al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α. FEBS Lett. 2012 Jul;586(16):2423-7 Pourvali K et al 2012/01/01 |
Species: Human, Applications: WB | |
| 182 |
Boysen G et al. Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia 2012 Jun;14(6):535-46 Boysen G et al 2012/01/01 |
Species: Human, Applications: WB | |
| 183 |
Nayak BK et al. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene 2012 Aug; Nayak BK et al 2012/01/01 |
Species: Human, Applications: WB | |
| 184 |
Wong CC et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc. Natl. Acad. Sci. U.S.A. 2011 Sep;108(39):16369-74 Wong CC et al 2011/01/01 |
Species: Human, Applications: WB | |
| 185 |
Chen R et al. The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling. J. Biol. Chem. 2012 Aug;287(36):30800-11 Chen R et al 2012/01/01 |
Species: Human, Applications: WB | |
| 186 |
Krishnamachary B et al. Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer. PLoS ONE 2012;7(8):e44078 Krishnamachary B et al 2012/01/01 |
Species: Human, Applications: WB | |
| 187 |
. ; |
Species: Mouse, Applications: IP, ChIP, WB | |
| 188 |
Anderson ER et al. The Hypoxia-Inducible Factor-C/EBPα Axis Controls Ethanol-Mediated Hepcidin Repression. Mol. Cell. Biol. 2012 Oct;32(19):4068-77 Anderson ER et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 189 |
Ho JJ et al. Functional importance of dicer protein in the adaptive cellular response to hypoxia. J. Biol. Chem. 2012 Aug;287(34):29003-20 Ho JJ et al 2012/01/01 |
Species: Human, Mouse, Applications: WB | |
| 190 |
Hubbi ME et al. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol. Cell 2011 Jun;42(5):700-12 Hubbi ME et al 2011/01/01 |
Species: Human, Applications: WB | |
| 191 |
Sciorra VA et al. Suppression of glioma progression by egln3. PLoS ONE 2012;7(8):e40053 Sciorra VA et al 2012/01/01 |
Species: Human, Rat, Applications: WB | |
| 192 |
Chiavarina B et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 2012 Sep;11(17):3280-9 Chiavarina B et al 2012/01/01 |
Applications: WB, ICC/IF | |
| 193 |
Hatano N et al. Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J. Biol. Chem. 2012 Sep;287(38):31962 Hatano N et al 2012/01/01 |
Applications: WB | |
| 194 |
Salnikov AV et al. Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential. PLoS ONE 2012;7(9):e46391 Salnikov AV et al 2012/01/01 |
Applications: IHC, ICC/IF | |
| 195 |
Higashimura Y et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 2011 May;509(1):1-8 Higashimura Y et al 2011/01/01 |
Applications: WB | |
| 196 |
Barshishat-Kupper M et al. Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Exp. Hematol. 2011 Mar;39(3):293-304 Barshishat-Kupper M et al 2011/01/01 |
Applications: WB | |
| 197 |
Pawlus MR et al. Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2α (HIF2α) Cooperatively Activate HIF2 Target Genes during Hypoxia. Mol. Cell. Biol. 2012 Nov;32(22):4595-610 Pawlus MR et al 2012/01/01 |
Applications: WB, ChIP | |
| 198 |
Lee J et al. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling. J. Cell. Biochem. 2012 Dec;113(12):3681-91 Lee J et al 2012/01/01 |
Species: Human, Applications: WB | |
| 199 |
Razorenova OV et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc. Natl. Acad. Sci. U.S.A. 2011 Feb;108(5):1931-6 Razorenova OV et al 2011/01/01 |
Species: Human, Applications: WB | |
| 200 |
Yamasaki T et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Cancer Sci. 2012 Nov;103(11):2027-37 Yamasaki T et al 2012/01/01 |
Species: Human, Applications: WB | |
| 201 |
Croci DO et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi"s sarcoma. J. Exp. Med. 2012 Oct;209(11):1985-2000 Croci DO et al 2012/01/01 |
Species: Human, Applications: WB | |
| 202 |
Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010 May;30(5):669-82 Copple BL 2010/01/01 |
Species: Mouse, Applications: WB | |
| 203 |
Gimm T et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010 Nov;24(11):4443-58 Gimm T et al 2010/01/01 |
Species: Human, Applications: WB | |
| 204 |
Emerling BM et al. Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc. Natl. Acad. Sci. U.S.A. 2013 Feb;110(9):3483-8 Emerling BM et al 2013/01/01 |
Species: Human, Applications: ChIP | |
| 205 |
Xu Y et al. The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 2013 Jan;266(2):187-97 Xu Y et al 2013/01/01 |
Species: Human, Applications: WB | |
| 206 |
Neelam S et al. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol. Vis. 2013;19:1-15 Neelam S et al 2013/01/01 |
Species: Human, Applications: WB | |
| 207 |
Storti P et al. Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia 2013 Jan; Storti P et al 2013/01/01 |
Species: Human, Applications: WB | |
| 208 |
Pang Y et al. The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. Toxicol. Lett. 2013 Apr;218(2):105-17 Pang Y et al 2013/01/01 |
Species: Human, Applications: WB | |
| 209 |
Gilkes DM et al. Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts. J. Biol. Chem. 2013 Apr;288(15):10819-29 Gilkes DM et al 2013/01/01 |
Species: Human, Applications: WB | |
| 210 |
Veeranna RP et al. Kaposi"s sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. J. Virol. 2012 Jan;86(2):1097-108 Veeranna RP et al 2012/01/01 |
Species: Human, Applications: WB, ChIP | |
| 211 |
Casagrande S et al. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. J. Pathol. 2013 Mar;229(4):525-34 Casagrande S et al 2013/01/01 |
Species: Human, Applications: WB | |
| 212 |
Choi HJ et al. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS ONE 2013;8(2):e56949 Choi HJ et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 213 |
Shimanishi M et al. Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia. J. Oral Pathol. Med. 2012 Dec; Shimanishi M et al 2012/01/01 |
Species: Human, Applications: WB | |
| 214 |
Gonzalez-Flores A et al. Interaction between PARP-1 and HIF-2α in the hypoxic response. Oncogene 2013 Mar; Gonzalez-Flores A et al 2013/01/01 |
Species: Mouse, Human, Applications: WB, IP | |
| 215 |
Vanharanta S et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 2013 Jan;19(1):50-6 Vanharanta S et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 216 |
Maruyama T et al. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PLoS ONE 2013;8(2):e56984 Maruyama T et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 217 |
Wu DC et al. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS ONE 2010;5(6):e11303 Wu DC et al 2010/01/01 |
Species: Mouse, Applications: ChIP | |
| 218 |
Gilkes D et al. Procollagen Lysyl Hydroxylase 2 is Essential for Breast Cancer Metastasis. Mol. Cancer Res. 2013 Feb; Gilkes D et al 2013/01/01 |
Applications: WB | |
| 219 |
Finger EC et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2013 Feb; Finger EC et al 2013/01/01 |
Species: Human, Applications: WB | |
| 220 |
Zhang Y et al. Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Sci. 2013 Apr;104(4):416-22 Zhang Y et al 2013/01/01 |
Species: Human, Applications: IHC-P, WB | |
| 221 |
Matak P et al. Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice. PLoS ONE 2013;8(3):e59538 Matak P et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 222 |
Mohlin S et al. HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 2013 Mar;15(3):328-34 Mohlin S et al 2013/01/01 |
Species: Human, Applications: IHC-P | |
| 223 |
Copple BL et al. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009 Aug;29(7):1010-21 Copple BL et al 2009/01/01 |
Species: Mouse, Applications: WB, ICC/IF | |
| 224 |
Parks SK et al. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J. Cell. Physiol. 2013 Sep;228(9):1854-62 Parks SK et al 2013/01/01 |
Species: Human, Applications: WB | |
| 225 |
van de Sluis B et al. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J. Clin. Invest. 2010 Jun;120(6):2119-30 van de Sluis B et al 2010/01/01 |
Species: Human, Applications: WB | |
| 226 |
Gilkes DM et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013 Jun;73(11):3285-96 Gilkes DM et al 2013/01/01 |
|
|
| 227 |
Rajakumar A et al. Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. Placenta 2008 Mar;29(3):290-9 Rajakumar A et al 2008/01/01 |
Species: Human, Applications: WB | |
| 228 |
Bohensky J et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009 May;60(5):1406-15 Bohensky J et al 2009/01/01 |
Species: Human, Mouse, Applications: IHC-P, ICC/IF | |
| 229 |
Mao XG et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro-oncology 2013 Jul;15(7):865-79 Mao XG et al 2013/01/01 |
Species: Human, Applications: WB, ChIP | |
| 230 |
Fu L et al. Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer Res. 2013 May;73(9):2916-25 Fu L et al 2013/01/01 |
Species: Mouse, Applications: IHC | |
| 231 |
Luo B et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis. Biochim. Biophys. Acta 2013 Aug;1832(8):1260-70 Luo B et al 2013/01/01 |
Species: Rat, Applications: WB | |
| 232 |
Pawlus MR et al. STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013 Apr; Pawlus MR et al 2013/01/01 |
Species: Human, Applications: WB | |
| 233 |
Ben-Shoshan J et al. Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties. Stem Cells 2008 Oct;26(10):2634-43 Ben-Shoshan J et al 2008/01/01 |
Species: Human, Applications: ELISA | |
| 234 |
Xie L et al. Transcription Factors Sp1 and Hif2α Mediate Induction of the Copper-transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells during Hypoxia. J. Biol. Chem. 2013 Aug;288(33):23943-52 Xie L et al 2013/01/01 |
Species: Rat, Applications: WB, ChIP | |
| 235 |
Forristal CE et al. Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells. PLoS ONE 2013;8(5):e62507 Forristal CE et al 2013/01/01 |
Species: Human, Applications: ChIP | |
| 236 |
Finley DS et al. Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report. Urol. Oncol. ;29(1):85-9 Finley DS et al |
Species: Human, Applications: IHC-P | |
| 237 |
Poitz DM et al. Regulation of the Hif-system by micro-RNA 17 and 20a - Role during monocyte-to-macrophage differentiation. Mol. Immunol. 2013 Jul;56(4):442-451 Poitz DM et al 2013/01/01 |
Species: Human, Applications: WB | |
| 238 |
Kim M et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013 Sep;5(9):1415-30 Kim M et al 2013/01/01 |
Species: Mouse, Applications: IHC-P | |
| 239 |
Rasbach KA et al. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc. Natl. Acad. Sci. U.S.A. 2010 Dec;107(50):21866-71 Rasbach KA et al 2010/01/01 |
Species: Mouse, Applications: WB | |
| 240 |
Wong WJ et al. MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Mol. Cell. Biol. 2013 Sep;33(17):3494-504 Wong WJ et al 2013/01/01 |
Species: Human, Applications: WB | |
| 241 |
Ikeda J et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2013 Jun;2(3):e000178 Ikeda J et al 2013/01/01 |
Species: Human, Applications: WB | |
| 242 |
You Q et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem. Pharmacol. 2013 Sep;86(6):836-43 You Q et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 243 |
Sato Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 2013 Aug;45(8):860-7 Sato Y et al 2013/01/01 |
Species: Human, Applications: IHC | |
| 244 |
Brackmann FA et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res. 2013 Sep;1531:65-74 Brackmann FA et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 245 |
Hubbi ME et al. Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors. J. Biol. Chem. 2013 Jul;288(29):20768-75 Hubbi ME et al 2013/01/01 |
Species: Human, Applications: WB | |
| 246 |
Xiang L et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J. Mol. Med. 2013 Nov; Xiang L et al 2013/01/01 |
|
|
| 247 |
Yuan HT et al. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am. J. Pathol. 2003 Dec;163(6):2289-301 Yuan HT et al 2003/01/01 |
Species: Mouse, Applications: IHC-P, WB | |
| 248 |
Luo X et al. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells. Biochim. Biophys. Acta 2014 Jan;1840(1):106-12 Luo X et al 2014/01/01 |
Species: Human, Applications: WB | |
| 249 |
Natsuizaka M et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012 Jun;26(6):2620-30 Natsuizaka M et al 2012/01/01 |
|
|
| 250 |
Befani C et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int. J. Biochem. Cell Biol. 2013 Nov;45(11):2359-68 Befani C et al 2013/01/01 |
Species: Human, Applications: WB | |
| 251 |
Qing G et al. Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res. 2010 Dec;70(24):10351-61 Qing G et al 2010/01/01 |
Species: Mouse, Human, Applications: WB, IHC | |
| 252 |
Thapa RJ et al. NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Mol. Cancer Ther. 2013 Aug;12(8):1568-78 Thapa RJ et al 2013/01/01 |
Species: Human, Applications: WB | |
| 253 |
Regan Anderson TM et al. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 2013 Sep;73(18):5810-20 Regan Anderson TM et al 2013/01/01 |
Species: Human, Applications: WB | |
| 254 |
Takeda K et al. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007 Aug;116(7):774-81 Takeda K et al 2007/01/01 |
Species: Mouse, Applications: WB | |
| 255 |
Wei K et al. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat. Med. 2013 Oct;19(10):1331-7 Wei K et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 256 |
Hu CJ et al. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007 Nov;18(11):4528-42 Hu CJ et al 2007/01/01 |
|
|
| 257 |
Doedens AL et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat. Immunol. 2013 Nov;14(11):1173-82 Doedens AL et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 258 |
Kerkel辰 R et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol. Cell. Biol. 2013 Aug;33(16):3321-9 Kerkel辰 R et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 259 |
Eckle T et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep;11(9):e1001665 Eckle T et al 2013/01/01 |
Species: Human, Applications: WB | |
| 260 |
Duan LJ et al. Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am. J. Pathol. 2011 Apr;178(4):1881-90 Duan LJ et al 2011/01/01 |
Species: Mouse, Applications: WB | |
| 261 |
Costa B et al. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J. 2010 Aug;24(8):2680-8 Costa B et al 2010/01/01 |
|
|
| 262 |
Cowburn AS et al. Epidermal Deletion of HIF-2α Stimulates Wound Closure. J. Invest. Dermatol. 2013 Sep; Cowburn AS et al 2013/01/01 |
Species: Human, Applications: WB | |
| 263 |
Pawlus MR et al. STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE 2013;8(8):e72358 Pawlus MR et al 2013/01/01 |
Species: Human, Applications: ChIP, WB | |
| 264 |
Razorenova OV et al. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol. Cell. Biol. 2014 Feb;34(4):739-51 Razorenova OV et al 2014/01/01 |
|
|
| 265 |
Proper SP et al. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol. Sci. 2014 Feb;137(2):447-57 Proper SP et al 2014/01/01 |
|
|
| 266 |
Pasupuleti V et al. Dysregulated D-dopachrome Tautomerase, a Hypoxia-inducible Factor-dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis. J. Biol. Chem. 2014 Feb;289(6):3713-23 Pasupuleti V et al 2014/01/01 |
|
|
| 267 |
Selvarajah J et al. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell Death Dis 2013;4:e865 Selvarajah J et al 2013/01/01 |
|
|
| 268 |
Bocca C et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin. Ther. Targets 2014 Feb;18(2):121-35 Bocca C et al 2014/01/01 |
|
|
| 269 |
Xu Z et al. MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α. PLoS ONE 2013;8(10):e77890 Xu Z et al 2013/01/01 |
|
|
| 270 |
Scholz CC et al. Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 2013 Nov;110(46):18490-5 Scholz CC et al 2013/01/01 |
|
|
| 271 |
Gilkes DM et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):E384-93 Gilkes DM et al 2014/01/01 |
|
|
| 272 |
Poitz DM et al. Regulation of the HIF-system in human macrophages--differential regulation of HIF-α subunits under sustained hypoxia. Mol. Immunol. 2014 Feb;57(2):226-35 Poitz DM et al 2014/01/01 |
|
|
| 273 |
Hanna C et al. Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis. Am. J. Physiol. Renal Physiol. 2013 Nov;305(9):F1323-31 Hanna C et al 2013/01/01 |
|
|
| 274 |
Glover LE et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc. Natl. Acad. Sci. U.S.A. 2013 Dec;110(49):19820-5 Glover LE et al 2013/01/01 |
|
|
| 275 |
Zhu J et al. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter. J. Lipid Res. 2014 Mar;55(3):431-42 Zhu J et al 2014/01/01 |
|
|
| 276 |
Kumar V et al. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur. J. Immunol. 2014 Mar;44(3):831-41 Kumar V et al 2014/01/01 |
|
|
| 277 |
Goetze O et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology 2013 Dec;58(6):2153-62 Goetze O et al 2013/01/01 |
|
|
| 278 |
Place TL et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS ONE 2013;8(12):e83021 Place TL et al 2013/01/01 |
|
|
| 279 |
Chen Z et al. Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS ONE 2013;8(12):e80337 Chen Z et al 2013/01/01 |
|
|
| 280 |
Takano N et al. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. Biochem. J. 2014 Mar;458(2):203-11 Takano N et al 2014/01/01 |
|
|
| 281 |
Cowburn AS et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc. Natl. Acad. Sci. U.S.A. 2013 Oct;110(43):17570-5 Cowburn AS et al 2013/01/01 |
|
|
| 282 |
Gomes AP et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013 Dec;155(7):1624-38 Gomes AP et al 2013/01/01 |
|
|
| 283 |
Nanduri J et al. Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia. PLoS ONE 2013;8(10):e75838 Nanduri J et al 2013/01/01 |
|
|
| 284 |
Mangiavini L et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev. Biol. 2014 Sep;393(1):124-36 Mangiavini L et al 2014/01/01 |
Species: Mouse, Applications: IHC-P | |
| 285 |
Slominski A et al. The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014 Dec;563:79-93 Slominski A et al 2014/01/01 |
Species: Human, Hamster, Applications: WB | |
| 286 |
Bordji K et al. Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells. FEBS J. 2014 Dec;281(23):5220-36 Bordji K et al 2014/01/01 |
Species: Human, Applications: WB, GS | |
| 287 |
Liu XD et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene 2014 Jul; Liu XD et al 2014/01/01 |
Species: Human, Applications: WB, IP, Co-IP | |
| 288 |
El Assar M et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br. J. Pharmacol. 2014 Nov; El Assar M et al 2014/01/01 |
Species: Rat, Applications: WB | |
| 289 |
Petruzzelli R et al. HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element. PLoS ONE 2014;9(10):e108309 Petruzzelli R et al 2014/01/01 |
Species: Human, Applications: ICC/IF, ChIP | |
| 290 |
Wojciak-Stothard B et al. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation 2014 Apr;129(17):1770-80 Wojciak-Stothard B et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 291 |
Furcht CM et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J. Cell. Sci. 2014 Aug;127(Pt 16):3555-67 Furcht CM et al 2014/01/01 |
Species: Human, Applications: WB | |
| 292 |
Kono K et al. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev. Biol. 2014 Oct;394(1):142-55 Kono K et al 2014/01/01 |
Species: Human, Hamster, Applications: WB | |
| 293 |
Rana S et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB J. 2014 Oct;28(10):4324-34 Rana S et al 2014/01/01 |
Species: Human, Applications: WB | |
| 294 |
Takano N et al. Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis. Mol. Cancer Res. 2014 Oct;12(10):1398-406 Takano N et al 2014/01/01 |
Species: Human, Applications: WB | |
| 295 |
Su EJ et al. Impaired Fetoplacental Angiogenesis in Growth-Restricted Fetuses With Abnormal Umbilical Artery Doppler Velocimetry Is Mediated by Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT). J. Clin. Endocrinol. Metab. 2015 Jan;100(1):E30-40 Su EJ et al 2015/01/01 |
Species: Human, Applications: WB | |
| 296 |
Chaturvedi P et al. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc. Natl. Acad. Sci. U.S.A. 2014 May;111(20):E2120-9 Chaturvedi P et al 2014/01/01 |
Species: Human, Applications: ChIP | |
| 297 |
Huang YH et al. Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol. Hum. Reprod. 2014 Jun;20(6):526-37 Huang YH et al 2014/01/01 |
Species: Mouse, Applications: ICC/IF, WB | |
| 298 |
Nagaya Y et al. Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α. Eur. J. Neurosci. 2014 Dec;40(11):3620-6 Nagaya Y et al 2014/01/01 |
Applications: WB | |
| 299 |
Qin N et al. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int. J. Cancer 2014 Nov;135(9):2054-64 Qin N et al 2014/01/01 |
Species: Human, Mouse, Applications: IHC-P, WB | |
| 300 |
Yoshizawa S et al. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater 2014 Jun;10(6):2834-42 Yoshizawa S et al 2014/01/01 |
Species: Human, Applications: WB | |
| 301 |
Hubbi ME et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proc. Natl. Acad. Sci. U.S.A. 2014 Aug;111(32):E3325-34 Hubbi ME et al 2014/01/01 |
Species: Human, Applications: WB | |
| 302 |
Hou P et al. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2. PLoS ONE 2014;9(11):e113865 Hou P et al 2014/01/01 |
Species: Human, Applications: WB | |
| 303 |
Samanta D et al. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 2014 Dec;111(50):E5429-38 Samanta D et al 2014/01/01 |
Species: Human, Applications: WB | |
| 304 |
Chen Z et al. EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300. Mol. Cell. Biol. 2014 Mar;34(6):1085-99 Chen Z et al 2014/01/01 |
Species: Human, Applications: WB | |
| 305 |
Chen SJ et al. A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α. J. Biol. Chem. 2014 Dec;289(52):36284-302 Chen SJ et al 2014/01/01 |
Species: Human, Applications: WB | |
| 306 |
Duan LJ et al. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am. J. Pathol. 2014 Apr;184(4):1240-50 Duan LJ et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 307 |
Zhang J et al. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet. Mol. Res. 2014;13(4):9324-35 Zhang J et al 2014/01/01 |
Species: Human, Applications: WB | |
| 308 |
Muz B et al. Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenstrom"s Macroglobulinemia. Mol. Cancer Res. 2014 Sep; Muz B et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 309 |
Qi Y et al. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2014 Nov; Qi Y et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 310 |
Ding Z et al. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun;74(11):3127-36 Ding Z et al 2014/01/01 |
Species: Human, Applications: WB | |
| 311 |
Zhou Y et al. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am. J. Pathol. 2014 Dec;184(12):3321-31 Zhou Y et al 2014/01/01 |
Species: Human, Applications: IHC | |
| 312 |
Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 2014;5:5582 Henze AT et al 2014/01/01 |
|
|
| 313 |
Heyboer M et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res 2014 May;12(3):638-45 Heyboer M et al 2014/01/01 |
Species: Human, Applications: FLOW | |
| 314 |
Weisel FC et al. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling. Circulation 2014 Apr;129(14):1510-23 Weisel FC et al 2014/01/01 |
Species: Mouse, Human, Applications: ChIP | |
| 315 |
Wilkinson N et al. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood 2013 Aug;122(9):1658-68 Wilkinson N et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 316 |
Wu R et al. Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. J. Clin. Invest. 2014 Nov;124(11):4795-806 Wu R et al 2014/01/01 |
Species: Human, Applications: ChIP | |
| 317 |
Asnaghi L et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE 2014;9(8):e105372 Asnaghi L et al 2014/01/01 |
Species: Human, Applications: WB | |
| 318 |
Arreola A et al. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PLoS ONE 2014;9(5):e98705 Arreola A et al 2014/01/01 |
Species: Mouse, Applications: ICC/IF | |
| 319 |
Hu H et al. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget 2014 Oct;5(19):8853-68 Hu H et al 2014/01/01 |
Species: Human, Applications: ChIP, WB | |
| 320 |
Lalev辿e S et al. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. Cell Death Dis 2014;5:e1408 Lalev辿e S et al 2014/01/01 |
|
|
| 321 |
Li B et al. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 2014 Sep;513(7517):251-5 Li B et al 2014/01/01 |
Species: Human, Applications: WB, IP | |
| 322 |
Lian G et al. Protein profiling of Helicobacter pylori-associated gastric cancer. Am. J. Pathol. 2014 May;184(5):1343-54 Lian G et al 2014/01/01 |
Species: Human, Applications: WB | |
| 323 |
Yoo S et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015 Jan;11(1):e1004898 Yoo S et al 2015/01/01 |
Species: Human, Applications: WB | |
| 324 |
Koh MY et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015 Jan;75(2):316-29 Koh MY et al 2015/01/01 |
Species: Human, Applications: WB | |
| 325 |
Neelam S et al. Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol. Vis. 2014;20:1758-75 Neelam S et al 2014/01/01 |
Species: Human, Applications: WB | |
| 326 |
Singleton DC et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene 2014 Dec;0 Singleton DC et al 2014/01/01 |
Species: Human, Applications: WB | |
| 327 |
Nozawa-Suzuki N et al. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer. Biochem. Biophys. Res. Commun. 2015 Feb;457(4):706-11 Nozawa-Suzuki N et al 2015/01/01 |
Species: Human, Applications: WB | |
| 328 |
Tsuboi I et al. Impaired expression of HIF -2α induces compensatory expression of HIF-1α for the recovery from anemia. J. Cell. Physiol. 2015 Jan; Tsuboi I et al 2015/01/01 |
Species: Mouse, Applications: WB, ChIP | |
| 329 |
Xiang L et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget 2014 Dec;5(24):12509-27 Xiang L et al 2014/01/01 |
Species: Human, Applications: ChIP, IP, WB | |
| 330 |
Gerovac BJ et al. Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner. Am. J. Respir. Cell Mol. Biol. 2014 Oct;51(4):516-25 Gerovac BJ et al 2014/01/01 |
|
|
| 331 |
Jimenez K et al. Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J. Thromb. Haemost. 2015 Feb; Jimenez K et al 2015/01/01 |
Species: Rat, Applications: IHC-P | |
| 332 |
Doonachar A et al. Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines. Cancer Cell Int. 2015;15:23 Doonachar A et al 2015/01/01 |
Species: Human, Applications: WB | |
| 333 |
Matak P et al. Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis. J. Immunol. 2015 Apr;194(7):3259-66 Matak P et al 2015/01/01 |
Species: Human, Applications: IHC-P | |
| 334 |
Salman S et al. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A. Am. J. Physiol., Cell Physiol. 2014 Aug;307(3):C266-77 Salman S et al 2014/01/01 |
Species: Rat, | |
| 335 |
Cotroneo E et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ. Res. 2015 May;116(10):1680-90 Cotroneo E et al 2015/01/01 |
Species: Rat, Applications: WB | |
| 336 |
Zeng H et al. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J. Cell. Mol. Med. 2015 Mar; Zeng H et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 337 |
Yoshizawa S et al. Role of magnesium ions on osteogenic response in bone marrow stromal cells. Connect. Tissue Res. 2014 Aug;55 Suppl 1:155-9 Yoshizawa S et al 2014/01/01 |
|
|
| 338 |
Fiorito V et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1. Biochim. Biophys. Acta 2014;1839(4):259-64 Fiorito V et al 2014/01/01 |
|
|
| 339 |
Chen R et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE 2015;10(2):e0116515 Chen R et al 2015/01/01 |
|
|
| 340 |
McMurray F et al. Pharmacological inhibition of FTO. PLoS ONE 2015;10(4):e0121829 McMurray F et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 341 |
Cassinat B et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell Cassinat B et al 2011/01/01 |
Species: Human, Applications: ChIP | |
| 342 |
Luo T et al. Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. Clin. Vaccine Imm Luo T et al 2010/01/01 |
Applications: WB | |
| 343 |
Zagzag D et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005 Jul;65(14):6178-88 Zagzag D et al 2005/01/01 |
Applications: IHC | |
| 344 |
Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010 Apr;70(8):3071-9 Zimmer M et al 2010/01/01 |
Species: Human, Applications: WB | |
| 345 |
Wu S et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther 2015;15(3):313-25 Wu S et al 2015/01/01 |
Species: Mouse | |
| 346 |
Forristal CE et al. Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia 2015 Oct;29(10):2075-85 Forristal CE et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 347 |
Koizume S et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol. Cancer 2015;14:77 Koizume S et al 2015/01/01 |
Species: Human, Applications: IHC-P, ICC/IF | |
| 348 |
Petrella BL et al. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005 Feb;24(6):1043-52 Petrella BL et al 2005/01/01 |
Species: Human, Applications: ELISA | |
| 349 |
Monsef N et al. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate 2007 Aug;67(11):1219-29 Monsef N et al 2007/01/01 |
Species: Human, Applications: ICC/IF | |
| 350 |
Lu H et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc. Natl. Acad. Sci. U.S.A. 2015 Aug;112(33):E4600-9 Lu H et al 2015/01/01 |
Species: Human, Applications: WB | |
| 351 |
Hickey MM et al. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J. Clin. Invest. 2007 Dec;117(12):3879-89 Hickey MM et al 2007/01/01 |
Applications: WB | |
| 352 |
Chiatar SS et al. Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation. Cell Dev Biol 2013 Aug;2 Chiatar SS et al 2013/01/01 |
Species: Human, Applications: WB | |
| 353 |
Liu YL et al. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol. Ther. 2006 Oct;5(10):1320-6 Liu YL et al 2006/01/01 |
Species: Human, Applications: FLOW | |
| 354 |
Pareek TK et al. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 2010 Oct;207(11):2507-19 Pareek TK et al 2010/01/01 |
Species: Mouse, Applications: WB | |
| 355 |
Shao J et al. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell. Dev. Biol. Anim. 2015 Sep;51(8):808-14 Shao J et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 356 |
Lin AE et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr;11(4):e1004818 Lin AE et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 357 |
H旦gel H et al. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol. Cancer 2015;14:143 H旦gel H et al 2015/01/01 |
Species: Human, Applications: WB | |
| 358 |
Rajakumar A et al. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 2004 Nov;25(10):763-9 Rajakumar A et al 2004/01/01 |
Species: Human, Applications: WB | |
| 359 |
Tanaka T et al. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem. J. 2009 Nov;424(1):143-51 Tanaka T et al 2009/01/01 |
Species: Human, Applications: WB | |
| 360 |
Moslehi J et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 2010 Sep;122(10):1004-16 Moslehi J et al 2010/01/01 |
Species: Mouse, Applications: WB | |
| 361 |
Lee S et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 2005 Aug;8(2):155-67 Lee S et al 2005/01/01 |
Species: Human, Applications: WB | |
| 362 |
Ramakrishnan SK et al. Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul;112(28):E3738-47 Ramakrishnan SK et al 2015/01/01 |
Species: Mouse, Applications: IHC-Fr | |
| 363 |
Monzon FA et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod. Pathol. 2011 Nov;24(11):1470-9 Monzon FA et al 2011/01/01 |
Species: Human, Applications: IHC | |
| 364 |
Liu MY et al. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res. 2003 May;63(10):2675-80 Liu MY et al 2003/01/01 |
Species: Rat | |
| 365 |
Chua RA et al. Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2. J. Am. Acad. Dermatol. 2009 Oct;61(4):730-2 Chua RA et al 2009/01/01 |
Species: Human | |
| 366 |
Matsuyama T et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur. J. Pharmacol. 2015 Aug;761:189-98 Matsuyama T et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 367 |
Przybytkowski E et al. Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability. FEBS J. 2009 Nov;276(21):6204-17 Przybytkowski E et al 2009/01/01 |
|
|
| 368 |
Wu S et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther. 2008 Jul;16(7):1227-34 Wu S et al 2008/01/01 |
Applications: WB | |
| 369 |
Sanchez M et al. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat. Struct. Mol. Biol. 2007 May;14(5):420-6 Sanchez M et al 2007/01/01 |
Species: Human, Applications: WB | |
| 370 |
Maltepe E et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 2005 Aug;132(15):3393-403 Maltepe E et al 2005/01/01 |
Species: Mouse, Applications: WB | |
| 371 |
Qiu B et al. HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov 2015 Jun;5(6):652-67 Qiu B et al 2015/01/01 |
Species: Human, Applications: WB | |
| 372 |
Evens AM et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br. J. Haematol. 2008 May;141(5):676-80 Evens AM et al 2008/01/01 |
Species: Human, Applications: WB | |
| 373 |
Che Y et al. Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma. Am. J. Pathol. 2012 May;180(5):1798-807 Che Y et al 2012/01/01 |
Species: Human, Applications: WB | |
| 374 |
Chiabrando D et al. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol. Dis. 2012 Aug; Chiabrando D et al 2012/01/01 |
|
|
| 375 |
Irwin R et al. Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype. J. Cell. Biochem. 2007 Feb;100(3):762-72 Irwin R et al 2007/01/01 |
Species: Mouse, Applications: WB | |
| 376 |
Highet AR et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur. J. Cell Biol. 2015 Dec;94(12):589-602 Highet AR et al 2015/01/01 |
|
|
| 377 |
Chen K et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J. Cell. Sci. 2016 Feb;129(4):817-30 Chen K et al 2016/01/01 |
|
|
| 378 |
Rodriguez S et al. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016 Aug;468(8):1433-48 Rodriguez S et al 2016/01/01 |
|
|
| 379 |
Sun W et al. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression. Cell. Physiol. Biochem. 2015;37(6):2257-64 Sun W et al 2015/01/01 |
|
|
| 380 |
Qian F et al. Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res 2015;7(11):2364-78 Qian F et al 2015/01/01 |
|
|
| 381 |
Cheng S et al. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology 2016 Jan;157(1):127-40 Cheng S et al 2016/01/01 |
|
|
| 382 |
Mandl M et al. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol 2015;10:229 Mandl M et al 2015/01/01 |
|
|
| 383 |
Regan Anderson TM et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016 Mar;76(6):1653-63 Regan Anderson TM et al 2016/01/01 |
|
|
| 384 |
Messai Y et al. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. Eur. Urol. 2015 Dec; Messai Y et al 2015/01/01 |
|
|
| 385 |
Zhang C et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget 2016 Aug; Zhang C et al 2016/01/01 |
|
|
| 386 |
Lee MC et al. Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep 2016;6:29311 Lee MC et al 2016/01/01 |
|
|
| 387 |
Aquino-G叩lvez A et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol. Rep. 2016 Jan;35(1):577-83 Aquino-G叩lvez A et al 2016/01/01 |
|
|
| 388 |
Mammadzada P et al. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis. Acta Ophthalmol 2016 Jun; Mammadzada P et al 2016/01/01 |
|
|
| 389 |
Zhang C et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc. Natl. Acad. Sci. U.S.A. 2016 Apr;113(14):E2047-56 Zhang C et al 2016/01/01 |
|
|
| 390 |
Pramono A et al. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop. Ann. N. Y. Acad. Sci. 2016 Jul;1375(1):38-51 Pramono A et al 2016/01/01 |
|
|
| 391 |
Warfel NA et al. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol. Cancer Ther. 2016 Jul;15(7):1637-47 Warfel NA et al 2016/01/01 |
|
|
| 392 |
Zeng H et al. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep 2016;6:20931 Zeng H et al 2016/01/01 |
|
|
| 393 |
Mahara S et al. HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc. Natl. Acad. Sci. U.S.A. 2016 Jun;113(26):E3735-44 Mahara S et al 2016/01/01 |
|
|
| 394 |
Higashimura Y et al. pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells. FEBS Lett. 2016 Aug;590(16):2690-9 Higashimura Y et al 2016/01/01 |
|
|
| 395 |
Mysore VS et al. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol. Cancer Res. 2016 Mar;14(3):253-66 Mysore VS et al 2016/01/01 |
|
|
| 396 |
Vukovic M et al. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. J. Exp. Med. 2015 Dec;212(13):2223-34 Vukovic M et al 2015/01/01 |
|
|
| 397 |
Mori H et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep 2016;6:21520 Mori H et al 2016/01/01 |
|
|
| 398 |
Fitzpatrick SF et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner. Biochem. Biophys. Res. Commun. 2016 Jun;474(3):579-86 Fitzpatrick SF et al 2016/01/01 |
|
|
| 399 |
Rad E et al. STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors. Mol. Cancer Res. 2015 Jul;13(7):1149-60 Rad E et al 2015/01/01 |
|
|
| 400 |
Zimmer M et al. Small-molecule inhibitors of HIF-2a translation link its 5"UTR iron-responsive element to oxygen sensing. Mol. Cell 2008 Dec;32(6):838-48 Zimmer M et al 2008/01/01 |
|
|
| 401 |
Zhang X et al. Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2α activity. Osteoarthr. Cartil. 2016 Jun; Zhang X et al 2016/01/01 |
|
|
| 402 |
Wang Y et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J. Clin. Invest. 2007 Jun;117(6):1616-26 Wang Y et al 2007/01/01 |
|
|
| 403 |
Hu CJ et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 2003 Dec;23(24):9361-74 Hu CJ et al 2003/01/01 |
|
|
| 404 |
Palladino MA et al. Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro. J. Androl. ;32(3):307-23 Palladino MA et al |
|
|
| 405 |
Li L et al. Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol. Cell. Biol. 2007 Aug;27(15):5381-92 Li L et al 2007/01/01 |
|
|
| 406 |
Glasmacher S. [Recommendation for vaccination against polio]. Gesundheitswesen 2014 Feb;76(2):71 Glasmacher S 2014/01/01 |
|
|
| 407 |
Selfridge AC et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J. Biol. Chem. 2016 May;291(22):11800-8 Selfridge AC et al 2016/01/01 |
|
|
| 408 |
Mandl M et al. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis 2016;7(6):e2284 Mandl M et al 2016/01/01 |
|
|
| 409 |
Saini Y et al. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS ONE 2015;10(9):e0139270 Saini Y et al 2015/01/01 |
|
|
| 410 |
Petrella BL et al. PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma. Cancer Biol. Ther. 2009 Jul;8(14):1389-401 Petrella BL et al 2009/01/01 |
|
|
| 411 |
Chen H et al. Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion. Eur. J. Pharmacol. 2016 Oct;789:354-61 Chen H et al 2016/01/01 |
|
|
| 412 |
Russell RC et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat. Med. 2011 Jul;17(7):845-53 Russell RC et al 2011/01/01 |
|
|
| 413 |
Kim WY et al. Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. EMBO J. 2006 Oct;25(19):4650-62 Kim WY et al 2006/01/01 |
|
|
| 414 |
Lomb DJ et al. Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J. Neurochem. 2007 Dec;103(5):1897-906 Lomb DJ et al 2007/01/01 |
|
|
| 415 |
Cannito S et al. Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. Oncotarget 2015 Feb;6(4):2206-21 Cannito S et al 2015/01/01 |
|
|
| 416 |
Manisterski M et al. Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α. Cell Cycle 2010 Sep;9(18):3723-9 Manisterski M et al 2010/01/01 |
|
|
| 417 |
Cavadas MA et al. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia. Sci Rep 2015;5:17851 Cavadas MA et al 2015/01/01 |
|
|
| 418 |
Otto T et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia? J. Cell. Biochem. 2015 Dec;116(12):2924-37 Otto T et al 2015/01/01 |
|
|
| 419 |
Kim Y et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun 2016 Jan;7:10347 Kim Y et al 2016/01/01 |
|
|
| 420 |
Laukka T et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J. Biol. Chem. 2016 Feb;291(8):4256-65 Laukka T et al 2016/01/01 |
|
|
| 421 |
Husted RF et al. Oxygen regulation of the epithelial Na channel in the collecting duct. Am. J. Physiol. Renal Physiol. 2011 Feb;300(2):F412-24 Husted RF et al 2011/01/01 |
|
|
| 422 |
Rankin EB et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J. Clin. Invest. 2007 Apr;117(4):1068-77 Rankin EB et al 2007/01/01 |
|
|
| 423 |
Groenman F et al. Hypoxia-inducible factors in the first trimester human lung. J. Histochem. Cytochem. 2007 Apr;55(4):355-63 Groenman F et al 2007/01/01 |
|
|
| 424 |
Gong H et al. HIF2α signaling inhibits adherens junctional disruption in acute lung injury. J. Clin. Invest. 2015 Feb;125(2):652-64 Gong H et al 2015/01/01 |
|
|
| 425 |
Mastrogiannaki M et al. HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J. Clin. Invest. 2009 May;119(5):1159-66 Mastrogiannaki M et al 2009/01/01 |
|
|
| 426 |
Lee SJ et al. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy 2011 Aug;7(8):829-39 Lee SJ et al 2011/01/01 |
|
|
| 427 |
Lee CM et al. VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo. Oncogene 2009 Apr;28(14):1694-705 Lee CM et al 2009/01/01 |
|
|
| 428 |
van Uden P et al. Evolutionary conserved regulation of HIF-1? by NF-?B. PLoS Genet. 2011;7(1):e1001285 van Uden P et al 2011/01/01 |
|
|
| 429 |
Mohanty SK. Multidimensional poverty and child survival in India. PLoS ONE 2011;6(10):e26857 Mohanty SK 2011/01/01 |
|
|
| 430 |
Yang Q et al. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Prot Yang Q et al 2018/01/01 |
Applications: WB | |
| 431 |
Gastelum G et al. Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PLoS ONE 2017;12(12):e01 Gastelum G et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 432 |
Dai Z et al. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α. Circulatio Dai Z et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 433 |
Huh YH et al. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res. Ther. 2015 Oct;17:302 Huh YH et al 2015/01/01 |
Species: Mouse, Applications: IHC | |
| 434 |
Ariazi JL et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J. Pharmacol. Exp. Ther. 2017 Dec;363(3):336-347 Ariazi JL et al 2017/01/01 |
Species: Human, Applications: WB | |
| 435 |
Woo JK et al. Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Cancer Prev Res (Phila) 2009 Apr;2(4):361-9 Woo JK et al 2009/01/01 |
Species: Mouse, Applications: WB | |
| 436 |
Prakash H et al. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep 2016 08;6:31490 Prakash H et al 2016/01/01 |
|
|
| 437 |
Ferecatu I et al. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation. PLoS ONE 2018;13(3):e0194782 Ferecatu I et al 2018/01/01 |
Species: Human, Applications: WB | |
| 438 |
Tsang KM et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α. Stem Cell Reports 2017 Sep;9(3):796-806 Tsang KM et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 439 |
Tang H et al. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am. J. Physiol. Lung Cell Mol. Physiol. 2018 02;314(2):L256-L275 Tang H et al 2018/01/01 |
Species: Human, Applications: WB | |
| 440 |
Megele R et al. Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series. Oncol Lett 2018 Nov;16(5):5813-5822 Megele R et al 2018/01/01 |
Species: Human, Applications: IHC-P | |
| 441 |
Hoang NT et al. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci. 2016 Aug;107(8):1151-8 Hoang NT et al 2016/01/01 |
Applications: WB | |
| 442 |
Christinat Y et al. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics 2016 07;32(14):2111-9 Christinat Y et al 2016/01/01 |
|
|
| 443 |
Landau D et al. The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia. PLoS ONE 2018;13(5):e0196684 Landau D et al 2018/01/01 |
Species: Rat, Applications: WB | |
| 444 |
Gstalder C et al. FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Mol. Cancer Ther. 2016 10;15(10):2465-2474 Gstalder C et al 2016/01/01 |
Applications: WB | |
| 445 |
Salati S et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget 2017 Jul;8(30):49451-49469 Salati S et al 2017/01/01 |
Species: Human, Applications: WB | |
| 446 |
Nauta TD et al. HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE 2016;11(8):e0160700 Nauta TD et al 2016/01/01 |
Species: Human, Applications: WB | |
| 447 |
Shi M et al. Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship. Am. J. Physiol. Renal Physiol. 2018 04;314(4):F501-F516 Shi M et al 2018/01/01 |
Species: Mouse | |
| 448 |
Kihira Y et al. Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS ONE 2014;9(4):e93856 Kihira Y et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 449 |
Nunomiya A et al. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf) 2016 Jul; Nunomiya A et al 2016/01/01 |
|
|
| 450 |
Nakayama T et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep 2016 11;6:36478 Nakayama T et al 2016/01/01 |
Species: Human, Applications: WB | |
| 451 |
Wang S et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget 2016 Sep;7(37):58848-58861 Wang S et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 452 |
Miess H et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 2018 Oct;37(40):5435-5450 Miess H et al 2018/01/01 |
Species: Human, Applications: WB | |
| 453 |
Ha JH et al. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics 2016 09;8(9):963-972 Ha JH et al 2016/01/01 |
|
|
| 454 |
Schofield HK et al. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol 2018;5(2):169-185.e2 Schofield HK et al 2018/01/01 |
Species: Mouse, Applications: IHC | |
| 455 |
Kozlova N et al. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget 2017 Feb;8(6):9885-9898 Kozlova N et al 2017/01/01 |
|
|
| 456 |
Maugeri G et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol 2016;7:139 Maugeri G et al 2016/01/01 |
WB | |
| 457 |
Regan Anderson TM et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol. Cancer Res. 2018 Nov;16(11):1761-1772 Regan Anderson TM et al 2018/01/01 |
Species: Human, Applications: WB | |
| 458 |
Bin坦 L et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem. Biol. Interact. 2016 Jan;244:204-14 Bin坦 L et al 2016/01/01 |
|
|
| 459 |
G旦rtz GE et al. Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves" Ophthalmopathy-Implications for Smoking. J. Clin. Endocrinol. Metab. 2016 12;101(12):4834-4842 G旦rtz GE et al 2016/01/01 |
|
|
| 460 |
Terzuoli E et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep;70(17):6837-48 Terzuoli E et al 2010/01/01 |
Species: Mouse, Applications: WB | |
| 461 |
Yasui T et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports 2017 06;8(6):1743-1756 Yasui T et al 2017/01/01 |
Species: Human, Applications: | |
| 462 |
Cho DC et al. The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma. Clin. Cancer Res. 2010 Jul;16(14):3628-38 Cho DC et al 2010/01/01 |
Species: Mouse, Applications: WB | |
| 463 |
Ambrosetti D et al. The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE 2018;13(2):e0193477 Ambrosetti D et al 2018/01/01 |
Species: Human, Applications: IHC | |
| 464 |
Kowitzke B et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J. Neuropathol. Exp. Neurol. 2016 Sep;75(9):827-42 Kowitzke B et al 2016/01/01 |
Species: Human, Applications: | |
| 465 |
Wang S et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J. Cell. Mol. Med. 2017 09;21(9):1967-1978 Wang S et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 466 |
Maybin JA et al. Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation. Nat Commun 2018 01;9(1):295 Maybin JA et al 2018/01/01 |
Species: Mouse, Applications: WB | |
| 467 |
You A et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol 2016 Mar;9:20 You A et al 2016/01/01 |
WB | |
| 468 |
D"Alessio A et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget 2016 Nov;7(48):78541-78556 D"Alessio A et al 2016/01/01 |
Species: Human, Applications: IHC | |
| 469 |
Frump AL et al. Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner. Am. J. Respir. Cell Mol. Biol. 2018 07;59(1):114-126 Frump AL et al 2018/01/01 |
Species: Rat, Applications: | |
| 470 |
Thompson JM et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene 2017 Feb;36(8):1080-1089 Thompson JM et al 2017/01/01 |
|
|
| 471 |
Ke S et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology 2017 01;65(1):134-151 Ke S et al 2017/01/01 |
|
|
| 472 |
Bhanu NV et al. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics 2016 Feb;16(3):448-58 Bhanu NV et al 2016/01/01 |
|
|
| 473 |
Kadam PD et al. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J 2016 Mar;27(3):505 Kadam PD et al 2016/01/01 |
|
|
| 474 |
Samanta D et al. Chemotherapy induces enrichment of CD47<sup>+</sup>/CD73<sup>+</sup>/PDL1<sup>+</sup> immune evasive triple-negative breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2018 02;115(6):E1239-E1248 Samanta D et al 2018/01/01 |
Species: Human, Applications: ChIP | |
| 475 |
Wu D et al. <i>HIF-1α</i> is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife 2017 05;6 Wu D et al 2017/01/01 |
Species: Human, Applications: Flow, WB | |
| 476 |
Fujikuni N et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci. 2014 Nov;105(11):1411-20 Fujikuni N et al 2014/01/01 |
WB | |
| 477 |
Yamamura K et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun 2017 Jan;8:13946 Yamamura K et al 2017/01/01 |
Species: Mouse, Applications: ICC/IF | |
| 478 |
Ma X et al. Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J. Biol. Chem. 2017 10;292(41):17046-17056 Ma X et al 2017/01/01 |
Species: Mouse, Applications: | |
| 479 |
Jain CV et al. Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding. Cell Death Differ. 2017 Oct;24(10):1772-1783 Jain CV et al 2017/01/01 |
WB | |
| 480 |
Sun L et al. Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma. Cancer Sci. 2017 Jul;108(7):1338-1346 Sun L et al 2017/01/01 |
Species: Human, Applications: WB | |
| 481 |
Thompson JM et al. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol. Cancer Ther. 2018 Aug;17(8):1781-1792 Thompson JM et al 2018/01/01 |
Species: Mouse, Applications: | |
| 482 |
Okamoto A et al. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep 2017 06;7(1):3816 Okamoto A et al 2017/01/01 |
|
|
| 483 |
Kumar VP et al. PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. Health Phys 2018 07;115(1):65-76 Kumar VP et al 2018/01/01 |
Species: Mouse, Applications: WB | |
| 484 |
Kim H et al. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Res. 2018 03;20(1):16 Kim H et al 2018/01/01 |
Species: Human, Applications: WB | |
| 485 |
B辰cker V et al. Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. PLoS ONE 2017;12(12):e0190074 B辰cker V et al 2017/01/01 |
Species: Mouse, Applications: IHC-P | |
| 486 |
Ho JC et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE 2017;12(11):e0188051 Ho JC et al 2017/01/01 |
Species: Human, Applications: WB | |
| 487 |
He X et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J. Mol. Cell. Cardiol. 2017 11;112:104-113 He X et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 488 |
Gardner PJ et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep 2017 01;7:40830 Gardner PJ et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 489 |
Pangou E et al. HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia. J. Cell. Sci. 2016 11;129(22):4213-4226 Pangou E et al 2016/01/01 |
|
|
| 490 |
Nam H et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes 2016 06;65(6):1521-33 Nam H et al 2016/01/01 |
Species: Human, Applications: WB | |
| 491 |
Bonora M et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene 2015 Mar;34(12):1608 Bonora M et al 2015/01/01 |
|
|
| 492 |
Hoppe-Seyler K et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2017 02;114(6):E990-E998 Hoppe-Seyler K et al 2017/01/01 |
Species: Human, Applications: IB | |
| 493 |
Dehn S et al. HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. J. Immunol. 2016 11;197(9):3639-3649 Dehn S et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 494 |
Sun W et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep 2017 Aug;7(1):7190 Sun W et al 2017/01/01 |
Species: Human, Applications: WB | |
| 495 |
Mira E et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nat Commun 2018 02;9(1):575 Mira E et al 2018/01/01 |
Species: Human, Applications: WB | |
| 496 |
Kuan II et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep 2017 Feb;7:41852 Kuan II et al 2017/01/01 |
|
|
| 497 |
Hoefflin R et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun 2016;7:ncomms11845 Hoefflin R et al 2016/01/01 |
IHC | |
| 498 |
Luo B et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun 2016;7:12177 Luo B et al 2016/01/01 |
WB | |
| 499 |
Bin坦 L et al. Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner. Oncotarget 2017 Oct;8(48):83684-83697 Bin坦 L et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 500 |
Timpano S et al. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J. Biol. Chem. 2016 May;291(20):10772-82 Timpano S et al 2016/01/01 |
|
|
| 501 |
Liu Z et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun 2017 09;8(1):584 Liu Z et al 2017/01/01 |
Species: Human, Applications: WB | |
| 502 |
Mao XG et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma. Oncotarget 2016 Jul;7(30):47808-47820 Mao XG et al 2016/01/01 |
Species: Human, Applications: ChIP | |
| 503 |
Depner C et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun 2016 Jul;7:12329 Depner C et al 2016/01/01 |
WB | |
| 504 |
Brooks DL et al. Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models. Methods Mol. Biol. 2018;1742:67-79 Brooks DL et al 2018/01/01 |
IP | |
| 505 |
Zhang J et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015 Dec;34(23):2953-70 Zhang J et al 2015/01/01 |
Species: Human, Applications: WB | |
| 506 |
Xie L et al. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J. Clin. Invest. 2018 Jun;128(6):2339-2355 Xie L et al 2018/01/01 |
WB | |
| 507 |
Luo W et al. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget 2016 Feb;7(6):6379-97 Luo W et al 2016/01/01 |
WB | |
| 508 |
Leinonen H et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum. Mol. Genet. 2016 09;25(17):3810-3823 Leinonen H et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 509 |
Casillas AL et al. Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin. Cancer Res. 2018 Jan;24(1):169-180 Casillas AL et al 2018/01/01 |
Species: Human, Applications: | |
| 510 |
Abdul-Aziz AM et al. HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene 2018 May;37(20):2676-2686 Abdul-Aziz AM et al 2018/01/01 |
WB | |
| 511 |
Du W et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism. Nat Commun 2017 11;8(1):1769 Du W et al 2017/01/01 |
Species: Human, Applications: WB | |
| 512 |
Zhang L et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J. Clin. Invest. 2016 12;126(12):4659-4673 Zhang L et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 513 |
Wong WJ et al. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J. Invest. Dermatol. 2015 Feb;135(2):454-61 Wong WJ et al 2015/01/01 |
WB | |
| 514 |
Isono T et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res 2016;6(10):2263-2276 Isono T et al 2016/01/01 |
Species: Human, Applications: | |
| 515 |
Lee HT et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics 2017;7(4):855-875 Lee HT et al 2017/01/01 |
Species: Rat, Applications: WB, IHC | |
| 516 |
Strowitzki MJ et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep 2017 Oct;7(1):13151 Strowitzki MJ et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 517 |
Kong KH et al. Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis. Sci Rep 2017 Sep;7(1):11351 Kong KH et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 518 |
Choi YH et al. Myocardial hypertrophy overrides the angiogenic response to hypoxia. PLoS ONE 2008;3(12):e4042 Choi YH et al 2008/01/01 |
Species: Rabbit, Applications: WB, ELISA | |
| 519 |
Zaini MN et al. Endogenous HIF2A reporter systems for high-throughput functional screening. Sci Rep 2018 Aug;8(1):12063 Zaini MN et al 2018/01/01 |
Species: Human, Applications: WB | |
| 520 |
Nakazawa MS et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun 2016 Feb;7:10539 Nakazawa MS et al 2016/01/01 |
WB | |
| 521 |
Senavirathna LK et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep 2018 Feb;8(1):2709 Senavirathna LK et al 2018/01/01 |
Species: Human, Applications: WB | |
| 522 |
Frey JL et al. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res 2014;2:14005 Frey JL et al 2014/01/01 |
IP | |
| 523 |
Xu M et al. Differential regulation of estrogen in iron metabolism in astrocytes and neurons. J. Cell. Physiol. 2018 Aug; Xu M et al 2018/01/01 |
Species: Rat, Applications: WB | |
| 524 |
Luo S et al. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene 2017 06;36(25):3609-3617 Luo S et al 2017/01/01 |
|
|
| 525 |
Yao X et al. <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov 2017 11;7(11):1284-1305 Yao X et al 2017/01/01 |
WB | |
| 526 |
Liu S et al. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma. Oncotarget 2017 Dec;8(70):115140-115152 Liu S et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 527 |
Ho JJD et al. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B. Cell Rep 2018 01;22(1):17-26 Ho JJD et al 2018/01/01 |
WB | |
| 528 |
Lim E et al. The prognosis outcome of oral squamous cell carcinoma using HIF-2α. J Chin Med Assoc 2017 Oct;80(10):651-656 Lim E et al 2017/01/01 |
Species: Human, Applications: IHC-P | |
| 529 |
Bテカト淌シrcテシ N et al. Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts. Methods Mol. Biol. 2018;1742:283-300 Bテカト淌シrcテシ N et al 2018/01/01 |
WB | |
| 530 |
Zhang X et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2014;2:14015 Zhang X et al 2014/01/01 |
IHC | |
| 531 |
German P et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene 2016 09;35(38):4973-80 German P et al 2016/01/01 |
|
|
| 532 |
Lu H et al. Chemotherapy-Induced Ca<sup>2+</sup> Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep 2017 02;18(8):1946-1957 Lu H et al 2017/01/01 |
Species: Human, Applications: WB, ChIP | |
| 533 |
Heir P et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J. Biol. Chem. 2016 Apr;291(14):7357-72 Heir P et al 2016/01/01 |
|
|
| 534 |
D鱈az-Trelles R et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun 2016 06;7:12088 D鱈az-Trelles R et al 2016/01/01 |
WB | |
| 535 |
van Uden P et al. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem. J. 2008 Jun;412(3):477-84 van Uden P et al 2008/01/01 |
Species: Mouse, Applications: WB | |
| 536 |
Robinson CM et al. Consequences of VHL Loss on Global DNA Methylome. Sci Rep 2018 Feb;8(1):3313 Robinson CM et al 2018/01/01 |
Species: Human, Applications: GS | |
| 537 |
Dobrynin G et al. KDM4A regulates HIF-1 levels through H3K9me3. Sci Rep 2017 Sep;7(1):11094 Dobrynin G et al 2017/01/01 |
Species: Human, Applications: WB | |
| 538 |
Cui J et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol. 2016 Jul; Cui J et al 2016/01/01 |
Species: Human, Applications: | |
| 539 |
Novianti T et al. Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration. Organogenesis 2019;15(3):69-84 Novianti T et al 2019/01/01 |
|
|
| 540 |
M辿sange P et al. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Oncotarget 20 M辿sange P et al 2014/01/01 |
|
|
| 541 |
Cannito S et al. SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets. Cancers (Basel) 2019 Dec;11(12) Cannito S et al 2019/01/01 |
|
|
| 542 |
Cohrs G et al. Expression Patterns of Hypoxia-Inducible Factors, Proinflammatory, and Neuroprotective Cytokines in Neuroepithelial Tissues of Lumbar Spinal Lipomas-A Pilot Study. World Neurosurg 2020 09;141:e633-e644 Cohrs G et al 2020/01/01 |
|
|
| 543 |
Qi D et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis 2019 07;10(8):544 Qi D et al 2019/01/01 |
|
|
| 544 |
Schwartz AJ et al. A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling. J Biol Chem 2019 10;294(41):14991-15002 Schwartz AJ et al 2019/01/01 |
|
|
| 545 |
Varghese J et al. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol 2020 Mar;58:126442 Varghese J et al 2020/01/01 |
|
|
| 546 |
Sumi C et al. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. PLoS One 2019;14(4):e0215072 Sumi C et al 2019/01/01 |
|
|
| 547 |
Fabbri L et al. Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients. Theranostics 2020;10(6):2696-2713 Fabbri L et al 2020/01/01 |
|
|
| 548 |
Roelants C et al. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma. Cancers (Basel) 2020 Jan;12(1) Roelants C et al 2020/01/01 |
|
|
| 549 |
Muenchau S et al. Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression. Mol Cell Biol 2019 07;39(14) Muenchau S et al 2019/01/01 |
|
|
| 550 |
Shneor D et al. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther 2017 Feb;24(2):64-74 Shneor D et al 2017/01/01 |
|
|
| 551 |
Lee YS et al. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv 2019 07;5(7):eaaw4176 Lee YS et al 2019/01/01 |
|
|
| 552 |
Park KT et al. Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. Biomolecules 2020 04;10(4) Park KT et al 2020/01/01 |
|
|
| 553 |
Riopel M et al. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism. Mol Metab 2020 11;41:101039 Riopel M et al 2020/01/01 |
|
|
| 554 |
Kurt B et al. Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo. J Am Soc Nephrol 2015 Mar;26(3):587-96 Kurt B et al 2015/01/01 |
|
|
| 555 |
Senavirathna LK et al. Hypoxia and transforming growth factor β1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts. Physiol Rep 2020 01;8(1):e14343 Senavirathna LK et al 2020/01/01 |
|
|
| 556 |
Brown E et al. Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients. FASEB J 2020 03;34(3):3732-3742 Brown E et al 2020/01/01 |
|
|
| 557 |
Sivaraj KK et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Elife 2020 01;9 Sivaraj KK et al 2020/01/01 |
|
|
| 558 |
Sun X et al. Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α. Am J Respir Cell Mol Biol 2020 07;63(1):92-103 Sun X et al 2020/01/01 |
|
|
| 559 |
Han S et al. The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis. Ther Adv Med Oncol 2019;11:1758835919875851 Han S et al 2019/01/01 |
|
|
| 560 |
van Gisbergen MW et al. Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets. Front Oncol 2020;10:770 van Gisbergen MW et al 2020/01/01 |
|
|
| 561 |
Chen L et al. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma. Theranostics 2020;10(8):3562-3578 Chen L et al 2020/01/01 |
|
|
| 562 |
Gao RY et al. Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology 2020 06;71(6):2105-2117 Gao RY et al 2020/01/01 |
|
|
| 563 |
Sadaghianloo N et al. Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia. J Cell Mol Med 2020 03;24(5):2931-2941 Sadaghianloo N et al 2020/01/01 |
|
|
| 564 |
Jeon GW et al. Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia. Korean J Pediatr 2019 Dec;62(12):444-449 Jeon GW et al 2019/01/01 |
|
|
| 565 |
Hart PC et al. Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep 2019 12;29(12):4086-4098.e6 Hart PC et al 2019/01/01 |
|
|
| 566 |
Park JH et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett 2020 05;478:71-81 Park JH et al 2020/01/01 |
|
|
| 567 |
Gojkovic M et al. Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE). Acta Physiol (Oxf) 2020 Jun;229(2):e13461 Gojkovic M et al 2020/01/01 |
|
|
| 568 |
Chang SH et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun 2019 03;10(1):1442 Chang SH et al 2019/01/01 |
|
|
| 569 |
Shoda C et al. Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy. Nutrients 2020 Apr;12(4) Shoda C et al 2020/01/01 |
|
|
| 570 |
Morikawa M et al. The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension. Sci Signal 2019 11;12(607) Morikawa M et al 2019/01/01 |
|
|
| 571 |
Stengel C et al. The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression. Anticancer Res 2015 Oct;35(10):5249-61 Stengel C et al 2015/01/01 |
|
|
| 572 |
Ho JJD et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism. Nat Commun 2020 05;11(1):2677 Ho JJD et al 2020/01/01 |
|
|
| 573 |
Dowdell AS et al. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell 2020 09;31(20):2249-2258 Dowdell AS et al 2020/01/01 |
|
|
| 574 |
Yoo HC et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Cell Metab 2020 02;31(2):267-283.e12 Yoo HC et al 2020/01/01 |
|
|
| 575 |
Xie C et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med 2017 Nov;23(11):1298-1308 Xie C et al 2017/01/01 |
|
|
| 576 |
David BT et al. Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord. eNeuro ;7(3) David BT et al |
|
|
| 577 |
Wu Y et al. Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells. Mol Cell Biochem 2020 Sep;472(1-2):19-31 Wu Y et al 2020/01/01 |
|
|
| 578 |
Zhang X et al. Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism. Cell Metab 2019 11;30(5):937-951.e5 Zhang X et al 2019/01/01 |
|
|
| 579 |
Kogure A et al. Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts. PLoS One 2020;15(6):e0234613 Kogure A et al 2020/01/01 |
|
|
| 580 |
Wang YJ et al. Reprogramming of m<sup>6</sup>A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia. RNA Biol 2021 01;18(1):131-143 Wang YJ et al 2021/01/01 |
|
|
| 581 |
Acosta-Iborra B et al. Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis. FASEB J 2020 05;34(5):6654-6674 Acosta-Iborra B et al 2020/01/01 |
|
|
| 582 |
Lu H et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest 2020 09;130(9):4607-4623 Lu H et al 2020/01/01 |
|
|
| 583 |
Yamamoto A et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest 2019 06;129(9):3640-3656 Yamamoto A et al 2019/01/01 |
|
|
| 584 |
Tashiro N et al. Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes. PLoS One 2019;14(11):e0224705 Tashiro N et al 2019/01/01 |
|
|
| 585 |
Seo JB et al. Knockdown of <i>Ant2</i> Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab 2019 01;1(1):86-97 Seo JB et al 2019/01/01 |
|
|
| 586 |
Samanta D et al. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep 2020 08;32(8):108073 Samanta D et al 2020/01/01 |
|
|
| 587 |
Hesse J et al. Normoxic induction of HIF-1α by adenosine-A<sub>2B</sub> R signaling in epicardial stromal cells formed after myocardial infarction. FASEB J 2021 05;35(5):e21517 Hesse J et al 2021/01/01 |
|
|
| 588 |
Romero Y et al. Antitumor Therapy under Hypoxic Microenvironment by the Combination of 2-Methoxyestradiol and Sodium Dichloroacetate on Human Non-Small-Cell Lung Cancer. Oxid Med Cell Longev 2020;2020:3176375 Romero Y et al 2020/01/01 |
|
|
| 589 |
Kida N et al. Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium. Antioxidants (Basel) 2021 Jan;10(1) Kida N et al 2021/01/01 |
|
|
| 590 |
Jack AR et al. A simple algorithm for evaluating dermatologic disease in critically ill patients: a study based on retrospective review of medical intensive care unit consults. J Am Acad Dermatol 2009 Oct;61(4):728-30 Jack AR et al 2009/01/01 |
|
|
| 591 |
Zhou Y et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl) 2020 10;98(10):1479-1491 Zhou Y et al 2020/01/01 |
|
|
| 592 |
Gkotinakou IM et al. Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism. Cells 2020 11;9(11) Gkotinakou IM et al 2020/01/01 |
|
|
| 593 |
Mehibel M et al. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest 2021 Jun;131(11) Mehibel M et al 2021/01/01 |
|
|
| 594 |
L坦pez-Rodr鱈guez DM et al. A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency. PLoS Pathog 2019 12;15(12):e1008192 L坦pez-Rodr鱈guez DM et al 2019/01/01 |
|
|
| 595 |
Tiwari A et al. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Gastroenterology 2020 11;159(5):1882-1897.e5 Tiwari A et al 2020/01/01 |
|
|
| 596 |
Zheng S et al. 2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop. Pharmacol Res 2021 Jul;169:105685 Zheng S et al 2021/01/01 |
|
|
| 597 |
Lee SY et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med 2021 Apr;53(4):591-604 Lee SY et al 2021/01/01 |
|
|
| 598 |
Chen K et al. Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma. Cancer Commun (Lond) 2021 Apr;41(4):316-332 Chen K et al 2021/01/01 |
|
|
| 599 |
Dufies M et al. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Commun Biol 2021 02;4(1):166 Dufies M et al 2021/01/01 |
|
|
| 600 |
Zhang Z et al. Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Cell Metab 2021 Aug;33(8):1624-1639.e9 Zhang Z et al 2021/01/01 |
|
|
| 601 |
Ju C et al. Hypoxia-inducible factor-1α-dependent induction of miR122 enhances hepatic ischemia tolerance. J Clin Invest 2021 Apr;131(7) Ju C et al 2021/01/01 |
|
|
| 602 |
Kozlova N et al. The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2. Cancer Res 2019 08;79(16):4042-4056 Kozlova N et al 2019/01/01 |
|
|
| 603 |
RawナＶszko-Wieczorek AA et al. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol Cancer Res 2014 Aug;12(8):1112-27 RawナＶszko-Wieczorek AA et al 2014/01/01 |
|
|
| 604 |
Tanimura A et al. MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade. Sci Rep 2021 Feb;11(1):3991 Tanimura A et al 2021/01/01 |
|
|
| 605 |
Ghosh MC et al. Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases. Blood 2021 May;137(18):2509-2519 Ghosh MC et al 2021/01/01 |
|
|
| 606 |
Kim H et al. A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nat Commun 2020 10;11(1):5023 Kim H et al 2020/01/01 |
|
|
| 607 |
Han Q et al. Notch3 is involved in the proliferation of renal cancer cells via regulation of cell cycle progression and HIF-2α. Oncol Lett 2020 Dec;20(6):379 Han Q et al 2020/01/01 |
|
|
| 608 |
Skwarska A et al. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Cell Chem Biol 2021 Apr; Skwarska A et al 2021/01/01 |
|
|
| 609 |
Wang R et al. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proc Natl Acad Sci U S A 2021 May;118(19) Wang R et al 2021/01/01 |
|
|
| 610 |
Uba T et al. Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner. Mitochondrion 2021 Jul;59:255-266 Uba T et al 2021/01/01 |
|
|
| 611 |
Sato H et al. Sodium butyrate enhances the growth inhibitory effect of sunitinib in human renal cell carcinoma cells. Oncol Lett 2017 Jul;14(1):937-943 Sato H et al 2017/01/01 |
|
|
| 612 |
Doan H et al. HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer. iScience 2019 Nov;21:509-520 Doan H et al 2019/01/01 |
|
|
| 613 |
He C et al. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A 2019 11;116(47):23534-23541 He C et al 2019/01/01 |
|
|
| 614 |
Xie H et al. Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma. Nat Metab 2021 03;3(3):327-336 Xie H et al 2021/01/01 |
|
|
| 615 |
Kleszka K et al. Hypoxia-inducible factor-2α is crucial for proper brain development. Sci Rep 2020 11;10(1):19146 Kleszka K et al 2020/01/01 |
|
|
| 616 |
Bennett LF et al. Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. Sci Signal 2019 09;12(598) Bennett LF et al 2019/01/01 |
|
|
| 617 |
Geng G et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. Elife 2021 May;10 Geng G et al 2021/01/01 |
|
|
| 618 |
Shao M et al. Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity. Cell Stem Cell 2021 04;28(4):685-701.e7 Shao M et al 2021/01/01 |
|
|
| 619 |
Li P et al. SIRT1 attenuates renal fibrosis by repressing HIF-2α. Cell Death Discov 2021 Mar;7(1):59 Li P et al 2021/01/01 |
|
|
| 620 |
Firmino NS et al. Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer. Oncoimmunology 2021;10(1):1959978 Firmino NS et al 2021/01/01 |
Species: Mouse, Applications: Flow | |
| 621 |
DeBerge M et al. Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair. J Exp Med 2021 09;218(9) DeBerge M et al 2021/01/01 |
Applications: IHC | |
| 622 |
Wang J et al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression. J Cancer 2021;12(17):5320-5330 Wang J et al 2021/01/01 |
Applications: ChIP | |
| 623 |
Li X et al. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance. Cell Rep 2021 Aug;36(8):109607 Li X et al 2021/01/01 |
Applications: ChIP, IP, ICC/IF | |
| 624 |
Caielli S et al. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell 2021 Aug;184(17):4464-4479.e19 Caielli S et al 2021/01/01 |
Species: Human, Applications: WB | |
- No.： 1
-
文献情報：
Conrad PW et al. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 1999 Nov;274(47):33709-13
Conrad PW et al
1999/01/01
-
備考：
-
参照：
- No.： 2
-
文献情報：
Ohh M et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2000 Jul;2(7):423-7
Ohh M et al
2000/01/01
-
備考：
-
参照：
- No.： 3
-
文献情報：
Rajakumar A et al. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol. Reprod. 2000 Aug;63(2):559-69
Rajakumar A et al
2000/01/01
-
備考：
-
参照：
- No.： 4
-
文献情報：
Bonicalzi ME et al. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 2001 Jan;276(2):1407-16
Bonicalzi ME et al
2001/01/01
-
備考：
-
参照：
- No.： 5
-
文献情報：
de Paulsen N et al. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2
de Paulsen N et al
2001/01/01
-
備考：
flow cytometry, western blot, human -
参照：
- No.： 6
-
文献情報：
Haase VH et al. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 2001 Feb;98(4):1583-8
Haase VH et al
2001/01/01
-
備考：
-
参照：
- No.： 7
-
文献情報：
Alvarez-Tejado M et al. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J. Biol. Chem. 2001 Jun;276(25):22368-74
Alvarez-Tejado M et al
2001/01/01
-
備考：
-
参照：
- No.： 8
-
文献情報：
Luo JC et al. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Oncogene 2001 Mar;20(12):1435-44
Luo JC et al
2001/01/01
-
備考：
-
参照：
- No.： 9
-
文献情報：
Makino Y et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001 Nov;414(6863):550-4
Makino Y et al
2001/01/01
-
備考：
-
参照：
- No.： 10
-
文献情報：
Minchenko A et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J. Biol. Chem. 2002 Feb;277(8):6183-7
Minchenko A et al
2002/01/01
-
備考：
-
参照：
- No.： 11
-
文献情報：
Burke B et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol. 2002 Feb;196(2):204-12
Burke B et al
2002/01/01
-
備考：
-
参照：
- No.： 12
-
文献情報：
Alvarez-Tejado M et al. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J. Biol. Chem. 2002 Apr;277(16):13508-17
Alvarez-Tejado M et al
2002/01/01
-
備考：
-
参照：
- No.： 13
-
文献情報：
Liang Y et al. Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. J. Biol. Chem. 2002 May;277(22):20087-94
Liang Y et al
2002/01/01
-
備考：
-
参照：
- No.： 14
-
文献情報：
Kondo K et al. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002 Apr;1(3):237-46
Kondo K et al
2002/01/01
-
備考：
-
参照：
- No.： 15
-
文献情報：
Maranchie JK et al. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002 Apr;1(3):247-55
Maranchie JK et al
2002/01/01
-
備考：
-
参照：
- No.： 16
-
文献情報：
Bernaudin M et al. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J. Biol. Chem. 2002 Oct;277(42):39728-38
Bernaudin M et al
2002/01/01
-
備考：
-
参照：
- No.： 17
-
文献情報：
Chan DA et al. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem. 2002 Oct;277(42):40112-7
Chan DA et al
2002/01/01
-
備考：
-
参照：
- No.： 18
-
文献情報：
Mack FA et al. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 2003 Jan;3(1):75-88
Mack FA et al
2003/01/01
-
備考：
-
参照：
- No.： 19
-
文献情報：
Yuan Y et al. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J. Biol. Chem. 2003 May;278(18):15911-6
Yuan Y et al
2003/01/01
-
備考：
-
参照：
- No.： 20
-
文献情報：
Del Toro R et al. Induction of T-type calcium channel gene expression by chronic hypoxia. J. Biol. Chem. 2003 Jun;278(25):22316-24
Del Toro R et al
2003/01/01
-
備考：
-
参照：
- No.： 21
-
文献情報：
Khatua S et al. Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res. 2003 Apr;63(8):1865-70
Khatua S et al
2003/01/01
-
備考：
-
参照：
- No.： 22
-
文献情報：
Mabjeesh NJ et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003 Apr;3(4):363-75
Mabjeesh NJ et al
2003/01/01
-
備考：
-
参照：
- No.： 23
-
文献情報：
Baba M et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene 2003 May;22(18):2728-38
Baba M et al
2003/01/01
-
備考：
-
参照：
- No.： 24
-
文献情報：
Naranjo-Su叩rez S et al. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J. Biol. Chem. 2003 Aug;278(34):31895-901
Naranjo-Su叩rez S et al
2003/01/01
-
備考：
-
参照：
- No.： 25
-
文献情報：
Park SK et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol. Cell. Biol. 2003 Jul;23(14):4959-71
Park SK et al
2003/01/01
-
備考：
-
参照：
- No.： 26
-
文献情報：
Mabjeesh NJ et al. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3"-kinase/protein kinase B in prostate cancer cells. Clin. Cancer Res. 2003 Jul;9(7):2416-25
Mabjeesh NJ et al
2003/01/01
-
備考：
-
参照：
- No.： 27
-
文献情報：
Palayoor ST et al. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin. Cancer Res. 2003 Aug;9(8):3150-7
Palayoor ST et al
2003/01/01
-
備考：
-
参照：
- No.： 28
-
文献情報：
Mohan S et al. von Hippel-Lindau protein complex is regulated by cell density. Oncogene 2003 Aug;22(34):5270-80
Mohan S et al
2003/01/01
-
備考：
-
参照：
- No.： 29
-
文献情報：
Staller P et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003 Sep;425(6955):307-11
Staller P et al
2003/01/01
-
備考：
-
参照：
- No.： 30
-
文献情報：
del Peso L et al. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J. Biol. Chem. 2003 Dec;278(49):48690-5
del Peso L et al
2003/01/01
-
備考：
-
参照：
- No.： 31
-
文献情報：
Corn PG et al. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat. Genet. 2003 Nov;35(3):229-37
Corn PG et al
2003/01/01
-
備考：
-
参照：
- No.： 32
-
文献情報：
Cuevas Y et al. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res. 2003 Oct;63(20):6877-84
Cuevas Y et al
2003/01/01
-
備考：
-
参照：
- No.： 33
-
文献情報：
Mart鱈n-Puig S et al. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J. Biol. Chem. 2004 Mar;279(10):9504-11
Mart鱈n-Puig S et al
2004/01/01
-
備考：
-
参照：
- No.： 34
-
文献情報：
Uchida T et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J. Biol. Chem. 2004 Apr;279(15):14871-8
Uchida T et al
2004/01/01
-
備考：
-
参照：
- No.： 35
-
文献情報：
Zimmer M et al. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2004 Feb;2(2):89-95
Zimmer M et al
2004/01/01
-
備考：
Western blot, ELISA, human/mouse -
参照：
- No.： 36
-
文献情報：
Mizukami Y et al. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 2004 Mar;64(5):1765-72
Mizukami Y et al
2004/01/01
-
備考：
-
参照：
- No.： 37
-
文献情報：
Welsh S et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol. Cancer Ther. 2004 Mar;3(3):233-44
Welsh S et al
2004/01/01
-
備考：
-
参照：
- No.： 38
-
文献情報：
Sato M et al. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am. J. Respir. Cell Mol. Biol. 2004 Aug;31(2):209-15
Sato M et al
2004/01/01
-
備考：
-
参照：
- No.： 39
-
文献情報：
Mekhail K et al. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat. Cell Biol. 2004 Jul;6(7):642-7
Mekhail K et al
2004/01/01
-
備考：
-
参照：
- No.： 40
-
文献情報：
Grabmaier K et al. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 2004 Jul;23(33):5624-31
Grabmaier K et al
2004/01/01
-
備考：
-
参照：
- No.： 41
-
文献情報：
Takeda N et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ. Res. 2004 Jul;95(2):146-53
Takeda N et al
2004/01/01
-
備考：
-
参照：
- No.： 42
-
文献情報：
Biju MP et al. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 2004 Oct;24(20):9038-47
Biju MP et al
2004/01/01
-
備考：
-
参照：
- No.： 43
-
文献情報：
Freeburg PB et al. Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. J. Am. Soc. Nephrol. 2004 Oct;15(10):2569-78
Freeburg PB et al
2004/01/01
-
備考：
-
参照：
- No.： 44
-
文献情報：
Tang N et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 2004 Nov;6(5):485-95
Tang N et al
2004/01/01
-
備考：
Western Blot, Mouse -
参照：
- No.： 45
-
文献情報：
Rathmell WK et al. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res. 2004 Dec;64(23):8595-603
Rathmell WK et al
2004/01/01
-
備考：
-
参照：
- No.： 46
-
文献情報：
Miller F et al. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J. Biol. Chem. 2005 Mar;280(9):7985-96
Miller F et al
2005/01/01
-
備考：
-
参照：
- No.： 47
-
文献情報：
Temes E et al. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J. Biol. Chem. 2005 Jun;280(25):24238-44
Temes E et al
2005/01/01
-
備考：
Western blot, human -
参照：
- No.： 48
-
文献情報：
Asikainen TM et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc. Natl. Acad. Sci. U.S.A. 2005 Jul;102(29):10212-7
Asikainen TM et al
2005/01/01
-
備考：
Western blot, human -
参照：
- No.： 49
-
文献情報：
Calvani M et al. Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 2006 Apr;107(7):2705-12
Calvani M et al
2006/01/01
-
備考：
-
参照：
- No.： 50
-
文献情報：
Schultz K et al. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 2006 Jun;290(6):H2528-34
Schultz K et al
2006/01/01
-
備考：
-
参照：
- No.： 51
-
文献情報：
Kurban G et al. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 2006 Feb;66(3):1313-9
Kurban G et al
2006/01/01
-
備考：
-
参照：
- No.： 52
-
文献情報：
Hui AS et al. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006 Mar;20(3):466-75
Hui AS et al
2006/01/01
-
備考：
-
参照：
- No.： 53
-
文献情報：
Krishnamachary B et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006 Mar;66(5):2725-31
Krishnamachary B et al
2006/01/01
-
備考：
-
参照：
- No.： 54
-
文献情報：
Mizukami Y et al. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J. Biol. Chem. 2006 May;281(20):13957-63
Mizukami Y et al
2006/01/01
-
備考：
-
参照：
- No.： 55
-
文献情報：
Okuyama H et al. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J. Biol. Chem. 2006 Jun;281(22):15554-63
Okuyama H et al
2006/01/01
-
備考：
-
参照：
- No.： 56
-
文献情報：
Ietta F et al. Dynamic HIF1A regulation during human placental development. Biol. Reprod. 2006 Jul;75(1):112-21
Ietta F et al
2006/01/01
-
備考：
-
参照：
- No.： 57
-
文献情報：
Hu CJ et al. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol. Cell. Biol. 2006 May;26(9):3514-26
Hu CJ et al
2006/01/01
-
備考：
-
参照：
- No.： 58
-
文献情報：
Nakamura K et al. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006 Apr;66(8):4249-55
Nakamura K et al
2006/01/01
-
備考：
-
参照：
- No.： 59
-
文献情報：
Bracken CP et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J. Biol. Chem. 2006 Aug;281(32):22575-85
Bracken CP et al
2006/01/01
-
備考：
-
参照：
- No.： 60
-
文献情報：
Hergovich A et al. Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Mol. Cell. Biol. 2006 Aug;26(15):5784-96
Hergovich A et al
2006/01/01
-
備考：
-
参照：
- No.： 61
-
文献情報：
Lutz MS et al. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res. 2006 Jul;66(14):6903-7
Lutz MS et al
2006/01/01
-
備考：
-
参照：
- No.： 62
-
文献情報：
Franovic A et al. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res. 2006 Aug;66(16):8083-90
Franovic A et al
2006/01/01
-
備考：
-
参照：
- No.： 63
-
文献情報：
Shinojima T et al. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Carcinogenesis 2007 Mar;28(3):529-36
Shinojima T et al
2007/01/01
-
備考：
-
参照：
- No.： 64
-
文献情報：
Lin Q et al. Differentiation arrest by hypoxia. J. Biol. Chem. 2006 Oct;281(41):30678-83
Lin Q et al
2006/01/01
-
備考：
-
参照：
- No.： 65
-
文献情報：
Carroll PA et al. Latent Kaposi"s sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J. Virol. 2006 Nov;80(21):10802-12
Carroll PA et al
2006/01/01
-
備考：
-
参照：
- No.： 66
-
文献情報：
Takeda K et al. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol. 2006 Nov;26(22):8336-46
Takeda K et al
2006/01/01
-
備考：
-
参照：
- No.： 67
-
文献情報：
Chavez JC et al. The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J. Neurosci. 2006 Sep;26(37):9471-81
Chavez JC et al
2006/01/01
-
備考：
-
参照：
- No.： 68
-
文献情報：
Koizume S et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res. 2006 Oct;66(19):9453-60
Koizume S et al
2006/01/01
-
備考：
-
参照：
- No.： 69
-
文献情報：
Evans AJ et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol. Cell. Biol. 2007 Jan;27(1):157-69
Evans AJ et al
2007/01/01
-
備考：
-
参照：
- No.： 70
-
文献情報：
Block K et al. NAD(P)H oxidases regulate HIF-2alpha protein expression. J. Biol. Chem. 2007 Mar;282(11):8019-26
Block K et al
2007/01/01
-
備考：
-
参照：
- No.： 71
-
文献情報：
Gruber M et al. Acute postnatal ablation of Hif-2alpha results in anemia. Proc. Natl. Acad. Sci. U.S.A. 2007 Feb;104(7):2301-6
Gruber M et al
2007/01/01
-
備考：
-
参照：
- No.： 72
-
文献情報：
MacKenzie ED et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 2007 May;27(9):3282-9
MacKenzie ED et al
2007/01/01
-
備考：
-
参照：
- No.： 73
-
文献情報：
Nagano M et al. Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood 2007 Jul;110(1):151-60
Nagano M et al
2007/01/01
-
備考：
-
参照：
- No.： 74
-
文献情報：
Zhang H et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007 May;11(5):407-20
Zhang H et al
2007/01/01
-
備考：
-
参照：
- No.： 75
-
文献情報：
Milkiewicz M et al. HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J. Physiol. (Lond.) 2007 Sep;583(Pt 2):753-66
Milkiewicz M et al
2007/01/01
-
備考：
-
参照：
- No.： 76
-
文献情報：
Cheng G et al. Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Nov;293(5):L1339-47
Cheng G et al
2007/01/01
-
備考：
-
参照：
- No.： 77
-
文献情報：
Minamishima YA et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 2008 Mar;111(6):3236-44
Minamishima YA et al
2008/01/01
-
備考：
-
参照：
- No.： 78
-
文献情報：
Lomb DJ et al. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of s
Lomb DJ et al
2009/01/01
-
備考：
-
参照：
- No.： 79
-
文献情報：
Rankin EB et al. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell 2012 Mar;149(1):63-74
Rankin EB et al
2012/01/01
-
備考：
-
参照：
- No.： 80
-
文献情報：
Rey S et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc. Natl. Acad. Sci. U.S.A. 2009 Dec;106(48):20399-404
Rey S et al
2009/01/01
-
備考：
-
参照：
- No.： 81
-
文献情報：
Koivunen P et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature 2012 Mar;483(7390):484-8
Koivunen P et al
2012/01/01
-
備考：
-
参照：
- No.： 82
-
文献情報：
Higashimura Y et al. Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. Biochem. Biophys. Res. Commun. 2011 Sep;413(2):201-5
Higashimura Y et al
2011/01/01
-
備考：
-
参照：
- No.： 83
-
文献情報：
Tuller ER et al. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol. Pharmacol. 2009 Sep;76(
Tuller ER et al
2009/01/01
-
備考：
-
参照：
- No.： 84
-
文献情報：
Singh M et al. Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta. Gynecol. Oncol. 2011 Jul;122(1):178-82
Singh M et al
2011/01/01
-
備考：
-
参照：
- No.： 85
-
文献情報：
Wiese M et al. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect. Immun. 2012 Apr;80(4):1455-66
Wiese M et al
2012/01/01
-
備考：
-
参照：
- No.： 86
-
文献情報：
Farrow EG et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc. Natl. Acad. Sci. U.S.A. 2011 Nov;108(46):E1146-55
Farrow EG et al
2011/01/01
-
備考：
-
参照：
- No.： 87
-
文献情報：
Luo W et al. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J. Biol. Chem. 2010 Feb;285(6):3651-63
Luo W et al
2010/01/01
-
備考：
-
参照：
- No.： 88
-
文献情報：
Peng YJ et al. Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc. Natl. Acad. Sci. U.S.A. 2011 Feb;108(7):3065-70
Peng YJ et al
2011/01/01
-
備考：
-
参照：
- No.： 89
-
文献情報：
Tsui AK et al. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc. Natl. Acad. Sci. U.S.A. 2011 Oct;108(42):17544-9
Tsui AK et al
2011/01/01
-
備考：
-
参照：
- No.： 90
-
文献情報：
Puppo M et al. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol. Cancer Ther. 2008 Jul;7(7):1974-84
Puppo M et al
2008/01/01
-
備考：
-
参照：
- No.： 91
-
文献情報：
Bohonowych JE et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer 2011;11:520
Bohonowych JE et al
2011/01/01
-
備考：
-
参照：
- No.： 92
-
文献情報：
Hu Z et al. Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2010 Nov;299(5):C930-8
Hu Z et al
2010/01/01
-
備考：
-
参照：
- No.： 93
-
文献情報：
Gabai VL et al. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol. Cell. Biol. 2012 Mar;32(5):929-40
Gabai VL et al
2012/01/01
-
備考：
-
参照：
- No.： 94
-
文献情報：
Kuzmanov A et al. Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Int. J. Cancer 2012 Sep;131(5):E603-13
Kuzmanov A et al
2012/01/01
-
備考：
-
参照：
- No.： 95
-
文献情報：
Xu Y et al. Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Arch. Toxicol. 2012 Jun;86(6):947-59
Xu Y et al
2012/01/01
-
備考：
-
参照：
- No.： 96
-
文献情報：
Conley SJ et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc. Natl. Acad. Sci. U.S.A. 2012 Feb;109(8):2784-9
Conley SJ et al
2012/01/01
-
備考：
-
参照：
- No.： 97
-
文献情報：
Koh MY et al. The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 2011 Jun;71(11):4015-27
Koh MY et al
2011/01/01
-
備考：
-
参照：
- No.： 98
-
文献情報：
Grover TR et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am. J. Physiol. Lung Cell Mol. Physiol. 2007 Jun;292(6):L1345-51
Grover TR et al
2007/01/01
-
備考：
-
参照：
- No.： 99
-
文献情報：
Yu B et al. Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model. J. Mol. Med. 2012 Aug;90(8):971-81
Yu B et al
2012/01/01
-
備考：
-
参照：
- No.： 100
-
文献情報：
Bussolati B et al. Hypoxia modulates the undifferentiated phenotype of human renal inner medullary CD133+ progenitors through Oct4/miR-145 balance. Am. J. Physiol. Renal Physiol. 2012 Jan;302(1):F116-28
Bussolati B et al
2012/01/01
-
備考：
-
参照：
- No.： 101
-
文献情報：
Biernat S. [Fibroxanthoma retroperitonei]. Wiad. Lek. 1976 May;29(9):845-8
Biernat S
1976/01/01
-
備考：
-
参照：
- No.： 102
-
文献情報：
Hansen SL et al. Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. J. Nutr. 2009 Aug;139(8):1474-9
Hansen SL et al
2009/01/01
-
備考：
-
参照：
- No.： 103
-
文献情報：
Brown ST et al. Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2α: role in modulating secretion. Biochem. Biophys. Res. Commun. 2011 Sep;412(3):466-72
Brown ST et al
2011/01/01
-
備考：
-
参照：
- No.： 104
-
文献情報：
Lange C et al. Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest. Ophthalmol. Vis. Sci. 2011 Jul;52(8):5872-80
Lange C et al
2011/01/01
-
備考：
-
参照：
- No.： 105
-
文献情報：
Copple BL et al. Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Liver Int. 2011 Feb;31(2):230-44
Copple BL et al
2011/01/01
-
備考：
-
参照：
- No.： 106
-
文献情報：
Koh MY et al. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol. Cell. Biol. 2008 Dec;28(23):7081-95
Koh MY et al
2008/01/01
-
備考：
-
参照：
- No.： 107
-
文献情報：
Yamashita T et al. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood 2008 Aug;112(4):1482-92
Yamashita T et al
2008/01/01
-
備考：
-
参照：
- No.： 108
-
文献情報：
Meyuhas R et al. A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Mol. Cancer Res. 2008 Sep;6(9):1397-409
Meyuhas R et al
2008/01/01
-
備考：
-
参照：
- No.： 109
-
文献情報：
Ginouv竪s A et al. PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc. Natl. Acad. Sci. U.S.A. 2008 Mar;105(12):4745-50
Ginouv竪s A et al
2008/01/01
-
備考：
-
参照：
- No.： 110
-
文献情報：
Lee K et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. U.S.A. 2009 Feb;106(7):2353-8
Lee K et al
2009/01/01
-
備考：
-
参照：
- No.： 111
-
文献情報：
Arab A et al. Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity. J. Pharmacol. Exp. Ther. 2008 May;325(2):417-24
Arab A et al
2008/01/01
-
備考：
-
参照：
- No.： 112
-
文献情報：
Lee K A et al. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol. Cancer Res. 2008 May;6(5):829-42
Lee K A et al
2008/01/01
-
備考：
-
参照：
- No.： 113
-
文献情報：
Xie L et al. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2011 Jun;300(6):C1298-305
Xie L et al
2011/01/01
-
備考：
-
参照：
- No.： 114
-
文献情報：
Sch旦del J et al. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am. J. Pathol. 2009 May;174(5):1663-74
Sch旦del J et al
2009/01/01
-
備考：
-
参照：
- No.： 115
-
文献情報：
Lu CW et al. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J. Biol. Chem. 2008 Oct;283(42):28106-14
Lu CW et al
2008/01/01
-
備考：
-
参照：
- No.： 116
-
文献情報：
Brown ST et al. Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am. J. Physiol., Cell Physiol. 2008 Jun;294(6):C1305-12
Brown ST et al
2008/01/01
-
備考：
-
参照：
- No.： 117
-
文献情報：
Walter A et al. Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. J. Pharmacol. Exp. Ther. 2009 May;329(2):699-707
Walter A et al
2009/01/01
-
備考：
-
参照：
- No.： 118
-
文献情報：
Martin SK et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica 2010 May;95(5):776-84
Martin SK et al
2010/01/01
-
備考：
-
参照：
- No.： 119
-
文献情報：
Fang HY et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009 Jul;114(4):844-59
Fang HY et al
2009/01/01
-
備考：
-
参照：
- No.： 120
-
文献情報：
Henze AT et al. Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res. 2010 Jan;70(1):357-66
Henze AT et al
2010/01/01
-
備考：
-
参照：
- No.： 121
-
文献情報：
Xu J et al. Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element. Oncogene 2012 Feb;31(8):1065-72
Xu J et al
2012/01/01
-
備考：
-
参照：
- No.： 122
-
文献情報：
Lange C et al. Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision. Neurobiol. Dis. 2011 Jan;41(1):119-30
Lange C et al
2011/01/01
-
備考：
-
参照：
- No.： 123
-
文献情報：
Ryu JH et al. Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ. 2012 Mar;19(3):440-50
Ryu JH et al
2012/01/01
-
備考：
-
参照：
- No.： 124
-
文献情報：
Sakoda Y et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J. Clin. Invest. 2011 Dec;121(12):4810-9
Sakoda Y et al
2011/01/01
-
備考：
-
参照：
- No.： 125
-
文献情報：
Hughes MD et al. HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer Cell Int. 2007;7:13
Hughes MD et al
2007/01/01
-
備考：
-
参照：
- No.： 126
-
文献情報：
Wacker I et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol. Cell. Biol. 2009 Apr;29(7):1707-18
Wacker I et al
2009/01/01
-
備考：
-
参照：
- No.： 127
-
文献情報：
Krieg AJ et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol. Cell. Biol. 2010 Jan;30(1):344-53
Krieg AJ et al
2010/01/01
-
備考：
-
参照：
- No.： 128
-
文献情報：
van Hagen M et al. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res. 2010 Apr;38(6):1922-31
van Hagen M et al
2010/01/01
-
備考：
-
参照：
- No.： 129
-
文献情報：
Zhou W et al. Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS ONE 2011;6(11):e27460
Zhou W et al
2011/01/01
-
備考：
-
参照：
- No.： 130
-
文献情報：
Hubbi ME et al. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J. Biol. Chem. 2012 Feb;287(9):6139-49
Hubbi ME et al
2012/01/01
-
備考：
-
参照：
- No.： 131
-
文献情報：
Zhang H et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec;105(50):19579-86
Zhang H et al
2008/01/01
-
備考：
-
参照：
- No.： 132
-
文献情報：
Kojima I et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J. Am. Soc. Nephrol. 2007 Apr;18(4):1218-26
Kojima I et al
2007/01/01
-
備考：
-
参照：
- No.： 133
-
文献情報：
Place TL et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE 2011;6(1):e14617
Place TL et al
2011/01/01
-
備考：
-
参照：
- No.： 134
-
文献情報：
Trollmann R et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008 Dec;295(6):R1973-81
Trollmann R et al
2008/01/01
-
備考：
-
参照：
- No.： 135
-
文献情報：
Sears JE et al. Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec;105(50):19898-903
Sears JE et al
2008/01/01
-
備考：
-
参照：
- No.： 136
-
文献情報：
Mahajan S et al. Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis 2008 Sep;29(9):1734-41
Mahajan S et al
2008/01/01
-
備考：
-
参照：
- No.： 137
-
文献情報：
Shen GM et al. Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. Biochem. J. 2012 Jan;441(2):675-83
Shen GM et al
2012/01/01
-
備考：
-
参照：
- No.： 138
-
文献情報：
Dutta D et al. Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. J. Biol. Chem. 2008 Sep;283(37):25404-13
Dutta D et al
2008/01/01
-
備考：
-
参照：
- No.： 139
-
文献情報：
Chen C et al. Association of elevated HIF-2α levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma. Ann. Surg. Oncol. 2011 Aug;18(8):2364-72
Chen C et al
2011/01/01
-
備考：
-
参照：
- No.： 140
-
文献情報：
Zhang H et al. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011 Jul;9(7):e1001112
Zhang H et al
2011/01/01
-
備考：
-
参照：
- No.： 141
-
文献情報：
Luu VD et al. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin. Cancer Res. 2009 May;15(10):3297-304
Luu VD et al
2009/01/01
-
備考：
-
参照：
- No.： 142
-
文献情報：
Bruning U et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol. Cell. Biol. 2011 Oct;31(19):4087-96
Bruning U et al
2011/01/01
-
備考：
-
参照：
- No.： 143
-
文献情報：
Graven KK et al. HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Biochim. Biophys. Acta 2003 Apr;1626(1-3):10-8
Graven KK et al
2003/01/01
-
備考：
-
参照：
- No.： 144
-
文献情報：
Metallo CM et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012 Jan;481(7381):380-4
Metallo CM et al
2012/01/01
-
備考：
-
参照：
- No.： 145
-
文献情報：
Franovic A et al. Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl. Acad. Sci. U.S.A. 2009 Dec;106(50):21306-11
Franovic A et al
2009/01/01
-
備考：
-
参照：
- No.： 146
-
文献情報：
Smith K et al. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005 Jun;65(12):5221-30
Smith K et al
2005/01/01
-
備考：
-
参照：
- No.： 147
-
文献情報：
Lee K et al. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc. Natl. Acad. Sci. U.S.A. 2009 Oct;106(42):17910-5
Lee K et al
2009/01/01
-
備考：
-
参照：
- No.： 148
-
文献情報：
Wang H et al. Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells. Mutat. Res. 2011 Aug;723(2):171-6
Wang H et al
2011/01/01
-
備考：
-
参照：
- No.： 149
-
文献情報：
Ad N et al. Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ann. Thorac. Surg. 2001 Sep;72(3):688-93
Ad N et al
2001/01/01
-
備考：
-
参照：
- No.： 150
-
文献情報：
Takeda K et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 2008 Mar;111(6):3229-35
Takeda K et al
2008/01/01
-
備考：
-
参照：
- No.： 151
-
文献情報：
Minamishima YA et al. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol. Cell. Biol. 2009 Nov;29(21):5729-41
Minamishima YA et al
2009/01/01
-
備考：
-
参照：
- No.： 152
-
文献情報：
Kanno T et al. JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Oncogene 2012 Jun;31(25):3098-110
Kanno T et al
2012/01/01
-
備考：
-
参照：
- No.： 153
-
文献情報：
Luo W et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011 May;145(5):732-44
Luo W et al
2011/01/01
-
備考：
-
参照：
- No.： 154
-
文献情報：
Matak P et al. Lack of iron-related phenotype in Sp6 intestinal knockout mice. Blood Cells Mol. Dis. 2011 Jun;47(1):46-9
Matak P et al
2011/01/01
-
備考：
-
参照：
- No.： 155
-
文献情報：
Zhou G et al. Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J. 2008 May;22(5):1335-42
Zhou G et al
2008/01/01
-
備考：
-
参照：
- No.： 156
-
文献情報：
Kim J et al. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology 2009 Jul;150(7):3392-400
Kim J et al
2009/01/01
-
備考：
-
参照：
- No.： 157
-
文献情報：
Ma Y et al. Prostate cancer cell lines under hypoxia exhibit greater stem-like properties. PLoS ONE 2011;6(12):e29170
Ma Y et al
2011/01/01
-
備考：
-
参照：
- No.： 158
-
文献情報：
Regazzetti C et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 2009 Jan;58(1):95-103
Regazzetti C et al
2009/01/01
-
備考：
-
参照：
- No.： 159
-
文献情報：
Nagao K et al. HIF-2 directly activates CD82 gene expression in endothelial cells. Biochem. Biophys. Res. Commun. 2011 Apr;407(1):260-5
Nagao K et al
2011/01/01
-
備考：
-
参照：
- No.： 160
-
文献情報：
Neal CS et al. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med 2010;8:64
Neal CS et al
2010/01/01
-
備考：
-
参照：
- No.： 161
-
文献情報：
Pan Y et al. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 2004 Jun;23(29):4975-83
Pan Y et al
2004/01/01
-
備考：
-
参照：
- No.： 162
-
文献情報：
Korgaonkar SN et al. HIV-1 upregulates VEGF in podocytes. J. Am. Soc. Nephrol. 2008 May;19(5):877-83
Korgaonkar SN et al
2008/01/01
-
備考：
-
参照：
- No.： 163
-
文献情報：
Xia G et al. Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology 2002 May;59(5):774-8
Xia G et al
2002/01/01
-
備考：
-
参照：
- No.： 164
-
文献情報：
Ren H et al. A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α. Invest. Ophthalmol. Vis. Sci. 2011 May;52(6):3112-8
Ren H et al
2011/01/01
-
備考：
Applications: WB, Species: Mouse -
参照：
- No.： 165
-
文献情報：
Valsecchi V et al. NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke 2011 Mar;42(3):754-63
Valsecchi V et al
2011/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 166
-
文献情報：
Poitz DM et al. OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway. Basic Res. Cardiol. 2011 Sep;106(5):761-72
Poitz DM et al
2011/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 167
-
文献情報：
Heddleston JM et al. Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ. 2012 Mar;19(3):428-39
Heddleston JM et al
2012/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 168
-
文献情報：
Zhang H et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012 Apr;31(14):1757-70
Zhang H et al
2012/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 169
-
文献情報：
Schrobback K et al. Effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Eng Part A 2012 May;18(9-10):920-33
Schrobback K et al
2012/01/01
-
備考：
Applications: IHC-Fr, IF, Species: Human -
参照：
- No.： 170
-
文献情報：
Ding Z et al. Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. J Biomol Screen 2012 Jun;17(5):572-80
Ding Z et al
2012/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 171
-
文献情報：
Salman S et al. Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Am. J. Physiol., Cell Physiol. 2012 May;302(10):C1531-8
Salman S et al
2012/01/01
-
備考：
Applications: WB, Species: Rat -
参照：
- No.： 172
-
文献情報：
Xu Y et al. EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells. PLoS ONE 2012;7(5):e37765
Xu Y et al
2012/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 173
-
文献情報：
Zhou Q et al. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization. FEBS Lett. 2012 May;586(10):1510-5
Zhou Q et al
2012/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 174
-
文献情報：
Uniacke J et al. An oxygen-regulated switch in the protein synthesis machinery. Nature 2012 Jun;486(7401):126-9
Uniacke J et al
2012/01/01
-
備考：
Applications: WB, Species: Human -
参照：
- No.： 175
-
文献情報：
Park SJ et al. L-2-Oxothiazolidine-4-Carboxylic Acid or α-Lipoic Acid Attenuates Airway Remodeling: Involvement of Nuclear Factor-κB (NF-κB), Nuclear Factor Erythroid 2p45-Related Factor-2 (Nrf2), and Hypoxia-Inducible Factor (HIF). Int
Park SJ et al
2012/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 176
-
文献情報：
Chintala S et al. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. BMC Cancer 2012;12:293
Chintala S et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 177
-
文献情報：
Park SJ et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm. Res. 2012 Oct;61(10):1069-83
Park SJ et al
2012/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 178
-
文献情報：
Bardella C et al. Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Mol. Cell. Biol. 2012 Aug;32(15):3081-94
Bardella C et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 179
-
文献情報：
Lee SW et al. Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Mol Med 2012 Sep;4(9):924-38
Lee SW et al
2012/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 180
-
文献情報：
Jham BC et al. Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi"s sarcoma. PLoS ONE 2011;6(4):e19103
Jham BC et al
2011/01/01
-
備考：
Species: Mouse, Human, Applications: IHC, WB -
参照：
- No.： 181
-
文献情報：
Pourvali K et al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α. FEBS Lett. 2012 Jul;586(16):2423-7
Pourvali K et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 182
-
文献情報：
Boysen G et al. Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia 2012 Jun;14(6):535-46
Boysen G et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 183
-
文献情報：
Nayak BK et al. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene 2012 Aug;
Nayak BK et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 184
-
文献情報：
Wong CC et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc. Natl. Acad. Sci. U.S.A. 2011 Sep;108(39):16369-74
Wong CC et al
2011/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 185
-
文献情報：
Chen R et al. The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling. J. Biol. Chem. 2012 Aug;287(36):30800-11
Chen R et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 186
-
文献情報：
Krishnamachary B et al. Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer. PLoS ONE 2012;7(8):e44078
Krishnamachary B et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 187
-
文献情報：
. ;
-
備考：
Species: Mouse, Applications: IP, ChIP, WB -
参照：
- No.： 188
-
文献情報：
Anderson ER et al. The Hypoxia-Inducible Factor-C/EBPα Axis Controls Ethanol-Mediated Hepcidin Repression. Mol. Cell. Biol. 2012 Oct;32(19):4068-77
Anderson ER et al
2012/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 189
-
文献情報：
Ho JJ et al. Functional importance of dicer protein in the adaptive cellular response to hypoxia. J. Biol. Chem. 2012 Aug;287(34):29003-20
Ho JJ et al
2012/01/01
-
備考：
Species: Human, Mouse, Applications: WB -
参照：
- No.： 190
-
文献情報：
Hubbi ME et al. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol. Cell 2011 Jun;42(5):700-12
Hubbi ME et al
2011/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 191
-
文献情報：
Sciorra VA et al. Suppression of glioma progression by egln3. PLoS ONE 2012;7(8):e40053
Sciorra VA et al
2012/01/01
-
備考：
Species: Human, Rat, Applications: WB -
参照：
- No.： 192
-
文献情報：
Chiavarina B et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 2012 Sep;11(17):3280-9
Chiavarina B et al
2012/01/01
-
備考：
Applications: WB, ICC/IF -
参照：
- No.： 193
-
文献情報：
Hatano N et al. Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J. Biol. Chem. 2012 Sep;287(38):31962
Hatano N et al
2012/01/01
-
備考：
Applications: WB -
参照：
- No.： 194
-
文献情報：
Salnikov AV et al. Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential. PLoS ONE 2012;7(9):e46391
Salnikov AV et al
2012/01/01
-
備考：
Applications: IHC, ICC/IF -
参照：
- No.： 195
-
文献情報：
Higashimura Y et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 2011 May;509(1):1-8
Higashimura Y et al
2011/01/01
-
備考：
Applications: WB -
参照：
- No.： 196
-
文献情報：
Barshishat-Kupper M et al. Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Exp. Hematol. 2011 Mar;39(3):293-304
Barshishat-Kupper M et al
2011/01/01
-
備考：
Applications: WB -
参照：
- No.： 197
-
文献情報：
Pawlus MR et al. Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2α (HIF2α) Cooperatively Activate HIF2 Target Genes during Hypoxia. Mol. Cell. Biol. 2012 Nov;32(22):4595-610
Pawlus MR et al
2012/01/01
-
備考：
Applications: WB, ChIP -
参照：
- No.： 198
-
文献情報：
Lee J et al. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling. J. Cell. Biochem. 2012 Dec;113(12):3681-91
Lee J et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 199
-
文献情報：
Razorenova OV et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc. Natl. Acad. Sci. U.S.A. 2011 Feb;108(5):1931-6
Razorenova OV et al
2011/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 200
-
文献情報：
Yamasaki T et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Cancer Sci. 2012 Nov;103(11):2027-37
Yamasaki T et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 201
-
文献情報：
Croci DO et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi"s sarcoma. J. Exp. Med. 2012 Oct;209(11):1985-2000
Croci DO et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 202
-
文献情報：
Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010 May;30(5):669-82
Copple BL
2010/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 203
-
文献情報：
Gimm T et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010 Nov;24(11):4443-58
Gimm T et al
2010/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 204
-
文献情報：
Emerling BM et al. Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc. Natl. Acad. Sci. U.S.A. 2013 Feb;110(9):3483-8
Emerling BM et al
2013/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 205
-
文献情報：
Xu Y et al. The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 2013 Jan;266(2):187-97
Xu Y et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 206
-
文献情報：
Neelam S et al. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol. Vis. 2013;19:1-15
Neelam S et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 207
-
文献情報：
Storti P et al. Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia 2013 Jan;
Storti P et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 208
-
文献情報：
Pang Y et al. The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. Toxicol. Lett. 2013 Apr;218(2):105-17
Pang Y et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 209
-
文献情報：
Gilkes DM et al. Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts. J. Biol. Chem. 2013 Apr;288(15):10819-29
Gilkes DM et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 210
-
文献情報：
Veeranna RP et al. Kaposi"s sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. J. Virol. 2012 Jan;86(2):1097-108
Veeranna RP et al
2012/01/01
-
備考：
Species: Human, Applications: WB, ChIP -
参照：
- No.： 211
-
文献情報：
Casagrande S et al. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. J. Pathol. 2013 Mar;229(4):525-34
Casagrande S et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 212
-
文献情報：
Choi HJ et al. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS ONE 2013;8(2):e56949
Choi HJ et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 213
-
文献情報：
Shimanishi M et al. Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia. J. Oral Pathol. Med. 2012 Dec;
Shimanishi M et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 214
-
文献情報：
Gonzalez-Flores A et al. Interaction between PARP-1 and HIF-2α in the hypoxic response. Oncogene 2013 Mar;
Gonzalez-Flores A et al
2013/01/01
-
備考：
Species: Mouse, Human, Applications: WB, IP -
参照：
- No.： 215
-
文献情報：
Vanharanta S et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 2013 Jan;19(1):50-6
Vanharanta S et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 216
-
文献情報：
Maruyama T et al. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PLoS ONE 2013;8(2):e56984
Maruyama T et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 217
-
文献情報：
Wu DC et al. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS ONE 2010;5(6):e11303
Wu DC et al
2010/01/01
-
備考：
Species: Mouse, Applications: ChIP -
参照：
- No.： 218
-
文献情報：
Gilkes D et al. Procollagen Lysyl Hydroxylase 2 is Essential for Breast Cancer Metastasis. Mol. Cancer Res. 2013 Feb;
Gilkes D et al
2013/01/01
-
備考：
Applications: WB -
参照：
- No.： 219
-
文献情報：
Finger EC et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2013 Feb;
Finger EC et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 220
-
文献情報：
Zhang Y et al. Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Sci. 2013 Apr;104(4):416-22
Zhang Y et al
2013/01/01
-
備考：
Species: Human, Applications: IHC-P, WB -
参照：
- No.： 221
-
文献情報：
Matak P et al. Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice. PLoS ONE 2013;8(3):e59538
Matak P et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 222
-
文献情報：
Mohlin S et al. HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 2013 Mar;15(3):328-34
Mohlin S et al
2013/01/01
-
備考：
Species: Human, Applications: IHC-P -
参照：
- No.： 223
-
文献情報：
Copple BL et al. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009 Aug;29(7):1010-21
Copple BL et al
2009/01/01
-
備考：
Species: Mouse, Applications: WB, ICC/IF -
参照：
- No.： 224
-
文献情報：
Parks SK et al. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J. Cell. Physiol. 2013 Sep;228(9):1854-62
Parks SK et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 225
-
文献情報：
van de Sluis B et al. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J. Clin. Invest. 2010 Jun;120(6):2119-30
van de Sluis B et al
2010/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 226
-
文献情報：
Gilkes DM et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013 Jun;73(11):3285-96
Gilkes DM et al
2013/01/01
-
備考：
-
参照：
- No.： 227
-
文献情報：
Rajakumar A et al. Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. Placenta 2008 Mar;29(3):290-9
Rajakumar A et al
2008/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 228
-
文献情報：
Bohensky J et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009 May;60(5):1406-15
Bohensky J et al
2009/01/01
-
備考：
Species: Human, Mouse, Applications: IHC-P, ICC/IF -
参照：
- No.： 229
-
文献情報：
Mao XG et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro-oncology 2013 Jul;15(7):865-79
Mao XG et al
2013/01/01
-
備考：
Species: Human, Applications: WB, ChIP -
参照：
- No.： 230
-
文献情報：
Fu L et al. Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer Res. 2013 May;73(9):2916-25
Fu L et al
2013/01/01
-
備考：
Species: Mouse, Applications: IHC -
参照：
- No.： 231
-
文献情報：
Luo B et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis. Biochim. Biophys. Acta 2013 Aug;1832(8):1260-70
Luo B et al
2013/01/01
-
備考：
Species: Rat, Applications: WB -
参照：
- No.： 232
-
文献情報：
Pawlus MR et al. STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013 Apr;
Pawlus MR et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 233
-
文献情報：
Ben-Shoshan J et al. Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties. Stem Cells 2008 Oct;26(10):2634-43
Ben-Shoshan J et al
2008/01/01
-
備考：
Species: Human, Applications: ELISA -
参照：
- No.： 234
-
文献情報：
Xie L et al. Transcription Factors Sp1 and Hif2α Mediate Induction of the Copper-transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells during Hypoxia. J. Biol. Chem. 2013 Aug;288(33):23943-52
Xie L et al
2013/01/01
-
備考：
Species: Rat, Applications: WB, ChIP -
参照：
- No.： 235
-
文献情報：
Forristal CE et al. Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells. PLoS ONE 2013;8(5):e62507
Forristal CE et al
2013/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 236
-
文献情報：
Finley DS et al. Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report. Urol. Oncol. ;29(1):85-9
Finley DS et al
-
備考：
Species: Human, Applications: IHC-P -
参照：
- No.： 237
-
文献情報：
Poitz DM et al. Regulation of the Hif-system by micro-RNA 17 and 20a - Role during monocyte-to-macrophage differentiation. Mol. Immunol. 2013 Jul;56(4):442-451
Poitz DM et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 238
-
文献情報：
Kim M et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013 Sep;5(9):1415-30
Kim M et al
2013/01/01
-
備考：
Species: Mouse, Applications: IHC-P -
参照：
- No.： 239
-
文献情報：
Rasbach KA et al. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc. Natl. Acad. Sci. U.S.A. 2010 Dec;107(50):21866-71
Rasbach KA et al
2010/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 240
-
文献情報：
Wong WJ et al. MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Mol. Cell. Biol. 2013 Sep;33(17):3494-504
Wong WJ et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 241
-
文献情報：
Ikeda J et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2013 Jun;2(3):e000178
Ikeda J et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 242
-
文献情報：
You Q et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem. Pharmacol. 2013 Sep;86(6):836-43
You Q et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 243
-
文献情報：
Sato Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 2013 Aug;45(8):860-7
Sato Y et al
2013/01/01
-
備考：
Species: Human, Applications: IHC -
参照：
- No.： 244
-
文献情報：
Brackmann FA et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res. 2013 Sep;1531:65-74
Brackmann FA et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 245
-
文献情報：
Hubbi ME et al. Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors. J. Biol. Chem. 2013 Jul;288(29):20768-75
Hubbi ME et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 246
-
文献情報：
Xiang L et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J. Mol. Med. 2013 Nov;
Xiang L et al
2013/01/01
-
備考：
-
参照：
- No.： 247
-
文献情報：
Yuan HT et al. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am. J. Pathol. 2003 Dec;163(6):2289-301
Yuan HT et al
2003/01/01
-
備考：
Species: Mouse, Applications: IHC-P, WB -
参照：
- No.： 248
-
文献情報：
Luo X et al. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells. Biochim. Biophys. Acta 2014 Jan;1840(1):106-12
Luo X et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 249
-
文献情報：
Natsuizaka M et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012 Jun;26(6):2620-30
Natsuizaka M et al
2012/01/01
-
備考：
-
参照：
- No.： 250
-
文献情報：
Befani C et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int. J. Biochem. Cell Biol. 2013 Nov;45(11):2359-68
Befani C et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 251
-
文献情報：
Qing G et al. Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res. 2010 Dec;70(24):10351-61
Qing G et al
2010/01/01
-
備考：
Species: Mouse, Human, Applications: WB, IHC -
参照：
- No.： 252
-
文献情報：
Thapa RJ et al. NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Mol. Cancer Ther. 2013 Aug;12(8):1568-78
Thapa RJ et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 253
-
文献情報：
Regan Anderson TM et al. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 2013 Sep;73(18):5810-20
Regan Anderson TM et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 254
-
文献情報：
Takeda K et al. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007 Aug;116(7):774-81
Takeda K et al
2007/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 255
-
文献情報：
Wei K et al. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat. Med. 2013 Oct;19(10):1331-7
Wei K et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 256
-
文献情報：
Hu CJ et al. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007 Nov;18(11):4528-42
Hu CJ et al
2007/01/01
-
備考：
-
参照：
- No.： 257
-
文献情報：
Doedens AL et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat. Immunol. 2013 Nov;14(11):1173-82
Doedens AL et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 258
-
文献情報：
Kerkel辰 R et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol. Cell. Biol. 2013 Aug;33(16):3321-9
Kerkel辰 R et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 259
-
文献情報：
Eckle T et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep;11(9):e1001665
Eckle T et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 260
-
文献情報：
Duan LJ et al. Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am. J. Pathol. 2011 Apr;178(4):1881-90
Duan LJ et al
2011/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 261
-
文献情報：
Costa B et al. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J. 2010 Aug;24(8):2680-8
Costa B et al
2010/01/01
-
備考：
-
参照：
- No.： 262
-
文献情報：
Cowburn AS et al. Epidermal Deletion of HIF-2α Stimulates Wound Closure. J. Invest. Dermatol. 2013 Sep;
Cowburn AS et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 263
-
文献情報：
Pawlus MR et al. STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE 2013;8(8):e72358
Pawlus MR et al
2013/01/01
-
備考：
Species: Human, Applications: ChIP, WB -
参照：
- No.： 264
-
文献情報：
Razorenova OV et al. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol. Cell. Biol. 2014 Feb;34(4):739-51
Razorenova OV et al
2014/01/01
-
備考：
-
参照：
- No.： 265
-
文献情報：
Proper SP et al. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol. Sci. 2014 Feb;137(2):447-57
Proper SP et al
2014/01/01
-
備考：
-
参照：
- No.： 266
-
文献情報：
Pasupuleti V et al. Dysregulated D-dopachrome Tautomerase, a Hypoxia-inducible Factor-dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis. J. Biol. Chem. 2014 Feb;289(6):3713-23
Pasupuleti V et al
2014/01/01
-
備考：
-
参照：
- No.： 267
-
文献情報：
Selvarajah J et al. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell Death Dis 2013;4:e865
Selvarajah J et al
2013/01/01
-
備考：
-
参照：
- No.： 268
-
文献情報：
Bocca C et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin. Ther. Targets 2014 Feb;18(2):121-35
Bocca C et al
2014/01/01
-
備考：
-
参照：
- No.： 269
-
文献情報：
Xu Z et al. MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α. PLoS ONE 2013;8(10):e77890
Xu Z et al
2013/01/01
-
備考：
-
参照：
- No.： 270
-
文献情報：
Scholz CC et al. Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 2013 Nov;110(46):18490-5
Scholz CC et al
2013/01/01
-
備考：
-
参照：
- No.： 271
-
文献情報：
Gilkes DM et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):E384-93
Gilkes DM et al
2014/01/01
-
備考：
-
参照：
- No.： 272
-
文献情報：
Poitz DM et al. Regulation of the HIF-system in human macrophages--differential regulation of HIF-α subunits under sustained hypoxia. Mol. Immunol. 2014 Feb;57(2):226-35
Poitz DM et al
2014/01/01
-
備考：
-
参照：
- No.： 273
-
文献情報：
Hanna C et al. Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis. Am. J. Physiol. Renal Physiol. 2013 Nov;305(9):F1323-31
Hanna C et al
2013/01/01
-
備考：
-
参照：
- No.： 274
-
文献情報：
Glover LE et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc. Natl. Acad. Sci. U.S.A. 2013 Dec;110(49):19820-5
Glover LE et al
2013/01/01
-
備考：
-
参照：
- No.： 275
-
文献情報：
Zhu J et al. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter. J. Lipid Res. 2014 Mar;55(3):431-42
Zhu J et al
2014/01/01
-
備考：
-
参照：
- No.： 276
-
文献情報：
Kumar V et al. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur. J. Immunol. 2014 Mar;44(3):831-41
Kumar V et al
2014/01/01
-
備考：
-
参照：
- No.： 277
-
文献情報：
Goetze O et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology 2013 Dec;58(6):2153-62
Goetze O et al
2013/01/01
-
備考：
-
参照：
- No.： 278
-
文献情報：
Place TL et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS ONE 2013;8(12):e83021
Place TL et al
2013/01/01
-
備考：
-
参照：
- No.： 279
-
文献情報：
Chen Z et al. Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS ONE 2013;8(12):e80337
Chen Z et al
2013/01/01
-
備考：
-
参照：
- No.： 280
-
文献情報：
Takano N et al. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. Biochem. J. 2014 Mar;458(2):203-11
Takano N et al
2014/01/01
-
備考：
-
参照：
- No.： 281
-
文献情報：
Cowburn AS et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc. Natl. Acad. Sci. U.S.A. 2013 Oct;110(43):17570-5
Cowburn AS et al
2013/01/01
-
備考：
-
参照：
- No.： 282
-
文献情報：
Gomes AP et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013 Dec;155(7):1624-38
Gomes AP et al
2013/01/01
-
備考：
-
参照：
- No.： 283
-
文献情報：
Nanduri J et al. Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia. PLoS ONE 2013;8(10):e75838
Nanduri J et al
2013/01/01
-
備考：
-
参照：
- No.： 284
-
文献情報：
Mangiavini L et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev. Biol. 2014 Sep;393(1):124-36
Mangiavini L et al
2014/01/01
-
備考：
Species: Mouse, Applications: IHC-P -
参照：
- No.： 285
-
文献情報：
Slominski A et al. The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014 Dec;563:79-93
Slominski A et al
2014/01/01
-
備考：
Species: Human, Hamster, Applications: WB -
参照：
- No.： 286
-
文献情報：
Bordji K et al. Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells. FEBS J. 2014 Dec;281(23):5220-36
Bordji K et al
2014/01/01
-
備考：
Species: Human, Applications: WB, GS -
参照：
- No.： 287
-
文献情報：
Liu XD et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene 2014 Jul;
Liu XD et al
2014/01/01
-
備考：
Species: Human, Applications: WB, IP, Co-IP -
参照：
- No.： 288
-
文献情報：
El Assar M et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br. J. Pharmacol. 2014 Nov;
El Assar M et al
2014/01/01
-
備考：
Species: Rat, Applications: WB -
参照：
- No.： 289
-
文献情報：
Petruzzelli R et al. HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element. PLoS ONE 2014;9(10):e108309
Petruzzelli R et al
2014/01/01
-
備考：
Species: Human, Applications: ICC/IF, ChIP -
参照：
- No.： 290
-
文献情報：
Wojciak-Stothard B et al. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation 2014 Apr;129(17):1770-80
Wojciak-Stothard B et al
2014/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 291
-
文献情報：
Furcht CM et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J. Cell. Sci. 2014 Aug;127(Pt 16):3555-67
Furcht CM et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 292
-
文献情報：
Kono K et al. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev. Biol. 2014 Oct;394(1):142-55
Kono K et al
2014/01/01
-
備考：
Species: Human, Hamster, Applications: WB -
参照：
- No.： 293
-
文献情報：
Rana S et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB J. 2014 Oct;28(10):4324-34
Rana S et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 294
-
文献情報：
Takano N et al. Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis. Mol. Cancer Res. 2014 Oct;12(10):1398-406
Takano N et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 295
-
文献情報：
Su EJ et al. Impaired Fetoplacental Angiogenesis in Growth-Restricted Fetuses With Abnormal Umbilical Artery Doppler Velocimetry Is Mediated by Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT). J. Clin. Endocrinol. Metab. 2015 Jan;100(1):E30-40
Su EJ et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 296
-
文献情報：
Chaturvedi P et al. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc. Natl. Acad. Sci. U.S.A. 2014 May;111(20):E2120-9
Chaturvedi P et al
2014/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 297
-
文献情報：
Huang YH et al. Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol. Hum. Reprod. 2014 Jun;20(6):526-37
Huang YH et al
2014/01/01
-
備考：
Species: Mouse, Applications: ICC/IF, WB -
参照：
- No.： 298
-
文献情報：
Nagaya Y et al. Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α. Eur. J. Neurosci. 2014 Dec;40(11):3620-6
Nagaya Y et al
2014/01/01
-
備考：
Applications: WB -
参照：
- No.： 299
-
文献情報：
Qin N et al. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int. J. Cancer 2014 Nov;135(9):2054-64
Qin N et al
2014/01/01
-
備考：
Species: Human, Mouse, Applications: IHC-P, WB -
参照：
- No.： 300
-
文献情報：
Yoshizawa S et al. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater 2014 Jun;10(6):2834-42
Yoshizawa S et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 301
-
文献情報：
Hubbi ME et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proc. Natl. Acad. Sci. U.S.A. 2014 Aug;111(32):E3325-34
Hubbi ME et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 302
-
文献情報：
Hou P et al. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2. PLoS ONE 2014;9(11):e113865
Hou P et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 303
-
文献情報：
Samanta D et al. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 2014 Dec;111(50):E5429-38
Samanta D et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 304
-
文献情報：
Chen Z et al. EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300. Mol. Cell. Biol. 2014 Mar;34(6):1085-99
Chen Z et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 305
-
文献情報：
Chen SJ et al. A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α. J. Biol. Chem. 2014 Dec;289(52):36284-302
Chen SJ et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 306
-
文献情報：
Duan LJ et al. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am. J. Pathol. 2014 Apr;184(4):1240-50
Duan LJ et al
2014/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 307
-
文献情報：
Zhang J et al. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet. Mol. Res. 2014;13(4):9324-35
Zhang J et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 308
-
文献情報：
Muz B et al. Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenstrom"s Macroglobulinemia. Mol. Cancer Res. 2014 Sep;
Muz B et al
2014/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 309
-
文献情報：
Qi Y et al. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2014 Nov;
Qi Y et al
2014/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 310
-
文献情報：
Ding Z et al. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun;74(11):3127-36
Ding Z et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 311
-
文献情報：
Zhou Y et al. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am. J. Pathol. 2014 Dec;184(12):3321-31
Zhou Y et al
2014/01/01
-
備考：
Species: Human, Applications: IHC -
参照：
- No.： 312
-
文献情報：
Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 2014;5:5582
Henze AT et al
2014/01/01
-
備考：
-
参照：
- No.： 313
-
文献情報：
Heyboer M et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res 2014 May;12(3):638-45
Heyboer M et al
2014/01/01
-
備考：
Species: Human, Applications: FLOW -
参照：
- No.： 314
-
文献情報：
Weisel FC et al. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling. Circulation 2014 Apr;129(14):1510-23
Weisel FC et al
2014/01/01
-
備考：
Species: Mouse, Human, Applications: ChIP -
参照：
- No.： 315
-
文献情報：
Wilkinson N et al. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood 2013 Aug;122(9):1658-68
Wilkinson N et al
2013/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 316
-
文献情報：
Wu R et al. Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. J. Clin. Invest. 2014 Nov;124(11):4795-806
Wu R et al
2014/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 317
-
文献情報：
Asnaghi L et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE 2014;9(8):e105372
Asnaghi L et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 318
-
文献情報：
Arreola A et al. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PLoS ONE 2014;9(5):e98705
Arreola A et al
2014/01/01
-
備考：
Species: Mouse, Applications: ICC/IF -
参照：
- No.： 319
-
文献情報：
Hu H et al. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget 2014 Oct;5(19):8853-68
Hu H et al
2014/01/01
-
備考：
Species: Human, Applications: ChIP, WB -
参照：
- No.： 320
-
文献情報：
Lalev辿e S et al. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. Cell Death Dis 2014;5:e1408
Lalev辿e S et al
2014/01/01
-
備考：
-
参照：
- No.： 321
-
文献情報：
Li B et al. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 2014 Sep;513(7517):251-5
Li B et al
2014/01/01
-
備考：
Species: Human, Applications: WB, IP -
参照：
- No.： 322
-
文献情報：
Lian G et al. Protein profiling of Helicobacter pylori-associated gastric cancer. Am. J. Pathol. 2014 May;184(5):1343-54
Lian G et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 323
-
文献情報：
Yoo S et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015 Jan;11(1):e1004898
Yoo S et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 324
-
文献情報：
Koh MY et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015 Jan;75(2):316-29
Koh MY et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 325
-
文献情報：
Neelam S et al. Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol. Vis. 2014;20:1758-75
Neelam S et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 326
-
文献情報：
Singleton DC et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene 2014 Dec;0
Singleton DC et al
2014/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 327
-
文献情報：
Nozawa-Suzuki N et al. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer. Biochem. Biophys. Res. Commun. 2015 Feb;457(4):706-11
Nozawa-Suzuki N et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 328
-
文献情報：
Tsuboi I et al. Impaired expression of HIF -2α induces compensatory expression of HIF-1α for the recovery from anemia. J. Cell. Physiol. 2015 Jan;
Tsuboi I et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB, ChIP -
参照：
- No.： 329
-
文献情報：
Xiang L et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget 2014 Dec;5(24):12509-27
Xiang L et al
2014/01/01
-
備考：
Species: Human, Applications: ChIP, IP, WB -
参照：
- No.： 330
-
文献情報：
Gerovac BJ et al. Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner. Am. J. Respir. Cell Mol. Biol. 2014 Oct;51(4):516-25
Gerovac BJ et al
2014/01/01
-
備考：
-
参照：
- No.： 331
-
文献情報：
Jimenez K et al. Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J. Thromb. Haemost. 2015 Feb;
Jimenez K et al
2015/01/01
-
備考：
Species: Rat, Applications: IHC-P -
参照：
- No.： 332
-
文献情報：
Doonachar A et al. Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines. Cancer Cell Int. 2015;15:23
Doonachar A et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 333
-
文献情報：
Matak P et al. Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis. J. Immunol. 2015 Apr;194(7):3259-66
Matak P et al
2015/01/01
-
備考：
Species: Human, Applications: IHC-P -
参照：
- No.： 334
-
文献情報：
Salman S et al. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A. Am. J. Physiol., Cell Physiol. 2014 Aug;307(3):C266-77
Salman S et al
2014/01/01
-
備考：
Species: Rat, -
参照：
- No.： 335
-
文献情報：
Cotroneo E et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ. Res. 2015 May;116(10):1680-90
Cotroneo E et al
2015/01/01
-
備考：
Species: Rat, Applications: WB -
参照：
- No.： 336
-
文献情報：
Zeng H et al. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J. Cell. Mol. Med. 2015 Mar;
Zeng H et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 337
-
文献情報：
Yoshizawa S et al. Role of magnesium ions on osteogenic response in bone marrow stromal cells. Connect. Tissue Res. 2014 Aug;55 Suppl 1:155-9
Yoshizawa S et al
2014/01/01
-
備考：
-
参照：
- No.： 338
-
文献情報：
Fiorito V et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1. Biochim. Biophys. Acta 2014;1839(4):259-64
Fiorito V et al
2014/01/01
-
備考：
-
参照：
- No.： 339
-
文献情報：
Chen R et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE 2015;10(2):e0116515
Chen R et al
2015/01/01
-
備考：
-
参照：
- No.： 340
-
文献情報：
McMurray F et al. Pharmacological inhibition of FTO. PLoS ONE 2015;10(4):e0121829
McMurray F et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 341
-
文献情報：
Cassinat B et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell
Cassinat B et al
2011/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 342
-
文献情報：
Luo T et al. Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. Clin. Vaccine Imm
Luo T et al
2010/01/01
-
備考：
Applications: WB -
参照：
- No.： 343
-
文献情報：
Zagzag D et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005 Jul;65(14):6178-88
Zagzag D et al
2005/01/01
-
備考：
Applications: IHC -
参照：
- No.： 344
-
文献情報：
Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010 Apr;70(8):3071-9
Zimmer M et al
2010/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 345
-
文献情報：
Wu S et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther 2015;15(3):313-25
Wu S et al
2015/01/01
-
備考：
Species: Mouse -
参照：
- No.： 346
-
文献情報：
Forristal CE et al. Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia 2015 Oct;29(10):2075-85
Forristal CE et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 347
-
文献情報：
Koizume S et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol. Cancer 2015;14:77
Koizume S et al
2015/01/01
-
備考：
Species: Human, Applications: IHC-P, ICC/IF -
参照：
- No.： 348
-
文献情報：
Petrella BL et al. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005 Feb;24(6):1043-52
Petrella BL et al
2005/01/01
-
備考：
Species: Human, Applications: ELISA -
参照：
- No.： 349
-
文献情報：
Monsef N et al. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate 2007 Aug;67(11):1219-29
Monsef N et al
2007/01/01
-
備考：
Species: Human, Applications: ICC/IF -
参照：
- No.： 350
-
文献情報：
Lu H et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc. Natl. Acad. Sci. U.S.A. 2015 Aug;112(33):E4600-9
Lu H et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 351
-
文献情報：
Hickey MM et al. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J. Clin. Invest. 2007 Dec;117(12):3879-89
Hickey MM et al
2007/01/01
-
備考：
Applications: WB -
参照：
- No.： 352
-
文献情報：
Chiatar SS et al. Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation. Cell Dev Biol 2013 Aug;2
Chiatar SS et al
2013/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 353
-
文献情報：
Liu YL et al. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol. Ther. 2006 Oct;5(10):1320-6
Liu YL et al
2006/01/01
-
備考：
Species: Human, Applications: FLOW -
参照：
- No.： 354
-
文献情報：
Pareek TK et al. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 2010 Oct;207(11):2507-19
Pareek TK et al
2010/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 355
-
文献情報：
Shao J et al. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell. Dev. Biol. Anim. 2015 Sep;51(8):808-14
Shao J et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 356
-
文献情報：
Lin AE et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr;11(4):e1004818
Lin AE et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 357
-
文献情報：
H旦gel H et al. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol. Cancer 2015;14:143
H旦gel H et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 358
-
文献情報：
Rajakumar A et al. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 2004 Nov;25(10):763-9
Rajakumar A et al
2004/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 359
-
文献情報：
Tanaka T et al. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem. J. 2009 Nov;424(1):143-51
Tanaka T et al
2009/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 360
-
文献情報：
Moslehi J et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 2010 Sep;122(10):1004-16
Moslehi J et al
2010/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 361
-
文献情報：
Lee S et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 2005 Aug;8(2):155-67
Lee S et al
2005/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 362
-
文献情報：
Ramakrishnan SK et al. Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul;112(28):E3738-47
Ramakrishnan SK et al
2015/01/01
-
備考：
Species: Mouse, Applications: IHC-Fr -
参照：
- No.： 363
-
文献情報：
Monzon FA et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod. Pathol. 2011 Nov;24(11):1470-9
Monzon FA et al
2011/01/01
-
備考：
Species: Human, Applications: IHC -
参照：
- No.： 364
-
文献情報：
Liu MY et al. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res. 2003 May;63(10):2675-80
Liu MY et al
2003/01/01
-
備考：
Species: Rat -
参照：
- No.： 365
-
文献情報：
Chua RA et al. Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2. J. Am. Acad. Dermatol. 2009 Oct;61(4):730-2
Chua RA et al
2009/01/01
-
備考：
Species: Human -
参照：
- No.： 366
-
文献情報：
Matsuyama T et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur. J. Pharmacol. 2015 Aug;761:189-98
Matsuyama T et al
2015/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 367
-
文献情報：
Przybytkowski E et al. Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability. FEBS J. 2009 Nov;276(21):6204-17
Przybytkowski E et al
2009/01/01
-
備考：
-
参照：
- No.： 368
-
文献情報：
Wu S et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther. 2008 Jul;16(7):1227-34
Wu S et al
2008/01/01
-
備考：
Applications: WB -
参照：
- No.： 369
-
文献情報：
Sanchez M et al. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat. Struct. Mol. Biol. 2007 May;14(5):420-6
Sanchez M et al
2007/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 370
-
文献情報：
Maltepe E et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 2005 Aug;132(15):3393-403
Maltepe E et al
2005/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 371
-
文献情報：
Qiu B et al. HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov 2015 Jun;5(6):652-67
Qiu B et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 372
-
文献情報：
Evens AM et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br. J. Haematol. 2008 May;141(5):676-80
Evens AM et al
2008/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 373
-
文献情報：
Che Y et al. Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma. Am. J. Pathol. 2012 May;180(5):1798-807
Che Y et al
2012/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 374
-
文献情報：
Chiabrando D et al. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol. Dis. 2012 Aug;
Chiabrando D et al
2012/01/01
-
備考：
-
参照：
- No.： 375
-
文献情報：
Irwin R et al. Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype. J. Cell. Biochem. 2007 Feb;100(3):762-72
Irwin R et al
2007/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 376
-
文献情報：
Highet AR et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur. J. Cell Biol. 2015 Dec;94(12):589-602
Highet AR et al
2015/01/01
-
備考：
-
参照：
- No.： 377
-
文献情報：
Chen K et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J. Cell. Sci. 2016 Feb;129(4):817-30
Chen K et al
2016/01/01
-
備考：
-
参照：
- No.： 378
-
文献情報：
Rodriguez S et al. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016 Aug;468(8):1433-48
Rodriguez S et al
2016/01/01
-
備考：
-
参照：
- No.： 379
-
文献情報：
Sun W et al. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression. Cell. Physiol. Biochem. 2015;37(6):2257-64
Sun W et al
2015/01/01
-
備考：
-
参照：
- No.： 380
-
文献情報：
Qian F et al. Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res 2015;7(11):2364-78
Qian F et al
2015/01/01
-
備考：
-
参照：
- No.： 381
-
文献情報：
Cheng S et al. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology 2016 Jan;157(1):127-40
Cheng S et al
2016/01/01
-
備考：
-
参照：
- No.： 382
-
文献情報：
Mandl M et al. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol 2015;10:229
Mandl M et al
2015/01/01
-
備考：
-
参照：
- No.： 383
-
文献情報：
Regan Anderson TM et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016 Mar;76(6):1653-63
Regan Anderson TM et al
2016/01/01
-
備考：
-
参照：
- No.： 384
-
文献情報：
Messai Y et al. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. Eur. Urol. 2015 Dec;
Messai Y et al
2015/01/01
-
備考：
-
参照：
- No.： 385
-
文献情報：
Zhang C et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget 2016 Aug;
Zhang C et al
2016/01/01
-
備考：
-
参照：
- No.： 386
-
文献情報：
Lee MC et al. Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep 2016;6:29311
Lee MC et al
2016/01/01
-
備考：
-
参照：
- No.： 387
-
文献情報：
Aquino-G叩lvez A et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol. Rep. 2016 Jan;35(1):577-83
Aquino-G叩lvez A et al
2016/01/01
-
備考：
-
参照：
- No.： 388
-
文献情報：
Mammadzada P et al. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis. Acta Ophthalmol 2016 Jun;
Mammadzada P et al
2016/01/01
-
備考：
-
参照：
- No.： 389
-
文献情報：
Zhang C et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA. Proc. Natl. Acad. Sci. U.S.A. 2016 Apr;113(14):E2047-56
Zhang C et al
2016/01/01
-
備考：
-
参照：
- No.： 390
-
文献情報：
Pramono A et al. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop. Ann. N. Y. Acad. Sci. 2016 Jul;1375(1):38-51
Pramono A et al
2016/01/01
-
備考：
-
参照：
- No.： 391
-
文献情報：
Warfel NA et al. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol. Cancer Ther. 2016 Jul;15(7):1637-47
Warfel NA et al
2016/01/01
-
備考：
-
参照：
- No.： 392
-
文献情報：
Zeng H et al. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep 2016;6:20931
Zeng H et al
2016/01/01
-
備考：
-
参照：
- No.： 393
-
文献情報：
Mahara S et al. HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc. Natl. Acad. Sci. U.S.A. 2016 Jun;113(26):E3735-44
Mahara S et al
2016/01/01
-
備考：
-
参照：
- No.： 394
-
文献情報：
Higashimura Y et al. pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells. FEBS Lett. 2016 Aug;590(16):2690-9
Higashimura Y et al
2016/01/01
-
備考：
-
参照：
- No.： 395
-
文献情報：
Mysore VS et al. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol. Cancer Res. 2016 Mar;14(3):253-66
Mysore VS et al
2016/01/01
-
備考：
-
参照：
- No.： 396
-
文献情報：
Vukovic M et al. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. J. Exp. Med. 2015 Dec;212(13):2223-34
Vukovic M et al
2015/01/01
-
備考：
-
参照：
- No.： 397
-
文献情報：
Mori H et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep 2016;6:21520
Mori H et al
2016/01/01
-
備考：
-
参照：
- No.： 398
-
文献情報：
Fitzpatrick SF et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner. Biochem. Biophys. Res. Commun. 2016 Jun;474(3):579-86
Fitzpatrick SF et al
2016/01/01
-
備考：
-
参照：
- No.： 399
-
文献情報：
Rad E et al. STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors. Mol. Cancer Res. 2015 Jul;13(7):1149-60
Rad E et al
2015/01/01
-
備考：
-
参照：
- No.： 400
-
文献情報：
Zimmer M et al. Small-molecule inhibitors of HIF-2a translation link its 5"UTR iron-responsive element to oxygen sensing. Mol. Cell 2008 Dec;32(6):838-48
Zimmer M et al
2008/01/01
-
備考：
-
参照：
- No.： 401
-
文献情報：
Zhang X et al. Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2α activity. Osteoarthr. Cartil. 2016 Jun;
Zhang X et al
2016/01/01
-
備考：
-
参照：
- No.： 402
-
文献情報：
Wang Y et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J. Clin. Invest. 2007 Jun;117(6):1616-26
Wang Y et al
2007/01/01
-
備考：
-
参照：
- No.： 403
-
文献情報：
Hu CJ et al. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 2003 Dec;23(24):9361-74
Hu CJ et al
2003/01/01
-
備考：
-
参照：
- No.： 404
-
文献情報：
Palladino MA et al. Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro. J. Androl. ;32(3):307-23
Palladino MA et al
-
備考：
-
参照：
- No.： 405
-
文献情報：
Li L et al. Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol. Cell. Biol. 2007 Aug;27(15):5381-92
Li L et al
2007/01/01
-
備考：
-
参照：
- No.： 406
-
文献情報：
Glasmacher S. [Recommendation for vaccination against polio]. Gesundheitswesen 2014 Feb;76(2):71
Glasmacher S
2014/01/01
-
備考：
-
参照：
- No.： 407
-
文献情報：
Selfridge AC et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J. Biol. Chem. 2016 May;291(22):11800-8
Selfridge AC et al
2016/01/01
-
備考：
-
参照：
- No.： 408
-
文献情報：
Mandl M et al. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis 2016;7(6):e2284
Mandl M et al
2016/01/01
-
備考：
-
参照：
- No.： 409
-
文献情報：
Saini Y et al. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS ONE 2015;10(9):e0139270
Saini Y et al
2015/01/01
-
備考：
-
参照：
- No.： 410
-
文献情報：
Petrella BL et al. PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma. Cancer Biol. Ther. 2009 Jul;8(14):1389-401
Petrella BL et al
2009/01/01
-
備考：
-
参照：
- No.： 411
-
文献情報：
Chen H et al. Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion. Eur. J. Pharmacol. 2016 Oct;789:354-61
Chen H et al
2016/01/01
-
備考：
-
参照：
- No.： 412
-
文献情報：
Russell RC et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat. Med. 2011 Jul;17(7):845-53
Russell RC et al
2011/01/01
-
備考：
-
参照：
- No.： 413
-
文献情報：
Kim WY et al. Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. EMBO J. 2006 Oct;25(19):4650-62
Kim WY et al
2006/01/01
-
備考：
-
参照：
- No.： 414
-
文献情報：
Lomb DJ et al. Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J. Neurochem. 2007 Dec;103(5):1897-906
Lomb DJ et al
2007/01/01
-
備考：
-
参照：
- No.： 415
-
文献情報：
Cannito S et al. Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. Oncotarget 2015 Feb;6(4):2206-21
Cannito S et al
2015/01/01
-
備考：
-
参照：
- No.： 416
-
文献情報：
Manisterski M et al. Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α. Cell Cycle 2010 Sep;9(18):3723-9
Manisterski M et al
2010/01/01
-
備考：
-
参照：
- No.： 417
-
文献情報：
Cavadas MA et al. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia. Sci Rep 2015;5:17851
Cavadas MA et al
2015/01/01
-
備考：
-
参照：
- No.： 418
-
文献情報：
Otto T et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia? J. Cell. Biochem. 2015 Dec;116(12):2924-37
Otto T et al
2015/01/01
-
備考：
-
参照：
- No.： 419
-
文献情報：
Kim Y et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun 2016 Jan;7:10347
Kim Y et al
2016/01/01
-
備考：
-
参照：
- No.： 420
-
文献情報：
Laukka T et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J. Biol. Chem. 2016 Feb;291(8):4256-65
Laukka T et al
2016/01/01
-
備考：
-
参照：
- No.： 421
-
文献情報：
Husted RF et al. Oxygen regulation of the epithelial Na channel in the collecting duct. Am. J. Physiol. Renal Physiol. 2011 Feb;300(2):F412-24
Husted RF et al
2011/01/01
-
備考：
-
参照：
- No.： 422
-
文献情報：
Rankin EB et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J. Clin. Invest. 2007 Apr;117(4):1068-77
Rankin EB et al
2007/01/01
-
備考：
-
参照：
- No.： 423
-
文献情報：
Groenman F et al. Hypoxia-inducible factors in the first trimester human lung. J. Histochem. Cytochem. 2007 Apr;55(4):355-63
Groenman F et al
2007/01/01
-
備考：
-
参照：
- No.： 424
-
文献情報：
Gong H et al. HIF2α signaling inhibits adherens junctional disruption in acute lung injury. J. Clin. Invest. 2015 Feb;125(2):652-64
Gong H et al
2015/01/01
-
備考：
-
参照：
- No.： 425
-
文献情報：
Mastrogiannaki M et al. HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J. Clin. Invest. 2009 May;119(5):1159-66
Mastrogiannaki M et al
2009/01/01
-
備考：
-
参照：
- No.： 426
-
文献情報：
Lee SJ et al. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy 2011 Aug;7(8):829-39
Lee SJ et al
2011/01/01
-
備考：
-
参照：
- No.： 427
-
文献情報：
Lee CM et al. VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo. Oncogene 2009 Apr;28(14):1694-705
Lee CM et al
2009/01/01
-
備考：
-
参照：
- No.： 428
-
文献情報：
van Uden P et al. Evolutionary conserved regulation of HIF-1? by NF-?B. PLoS Genet. 2011;7(1):e1001285
van Uden P et al
2011/01/01
-
備考：
-
参照：
- No.： 429
-
文献情報：
Mohanty SK. Multidimensional poverty and child survival in India. PLoS ONE 2011;6(10):e26857
Mohanty SK
2011/01/01
-
備考：
-
参照：
- No.： 430
-
文献情報：
Yang Q et al. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Prot
Yang Q et al
2018/01/01
-
備考：
Applications: WB -
参照：
- No.： 431
-
文献情報：
Gastelum G et al. Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PLoS ONE 2017;12(12):e01
Gastelum G et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 432
-
文献情報：
Dai Z et al. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α. Circulatio
Dai Z et al
2016/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 433
-
文献情報：
Huh YH et al. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res. Ther. 2015 Oct;17:302
Huh YH et al
2015/01/01
-
備考：
Species: Mouse, Applications: IHC -
参照：
- No.： 434
-
文献情報：
Ariazi JL et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J. Pharmacol. Exp. Ther. 2017 Dec;363(3):336-347
Ariazi JL et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 435
-
文献情報：
Woo JK et al. Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Cancer Prev Res (Phila) 2009 Apr;2(4):361-9
Woo JK et al
2009/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 436
-
文献情報：
Prakash H et al. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep 2016 08;6:31490
Prakash H et al
2016/01/01
-
備考：
-
参照：
- No.： 437
-
文献情報：
Ferecatu I et al. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation. PLoS ONE 2018;13(3):e0194782
Ferecatu I et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 438
-
文献情報：
Tsang KM et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α. Stem Cell Reports 2017 Sep;9(3):796-806
Tsang KM et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 439
-
文献情報：
Tang H et al. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am. J. Physiol. Lung Cell Mol. Physiol. 2018 02;314(2):L256-L275
Tang H et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 440
-
文献情報：
Megele R et al. Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series. Oncol Lett 2018 Nov;16(5):5813-5822
Megele R et al
2018/01/01
-
備考：
Species: Human, Applications: IHC-P -
参照：
- No.： 441
-
文献情報：
Hoang NT et al. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci. 2016 Aug;107(8):1151-8
Hoang NT et al
2016/01/01
-
備考：
Applications: WB -
参照：
- No.： 442
-
文献情報：
Christinat Y et al. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics 2016 07;32(14):2111-9
Christinat Y et al
2016/01/01
-
備考：
-
参照：
- No.： 443
-
文献情報：
Landau D et al. The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia. PLoS ONE 2018;13(5):e0196684
Landau D et al
2018/01/01
-
備考：
Species: Rat, Applications: WB -
参照：
- No.： 444
-
文献情報：
Gstalder C et al. FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Mol. Cancer Ther. 2016 10;15(10):2465-2474
Gstalder C et al
2016/01/01
-
備考：
Applications: WB -
参照：
- No.： 445
-
文献情報：
Salati S et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget 2017 Jul;8(30):49451-49469
Salati S et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 446
-
文献情報：
Nauta TD et al. HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE 2016;11(8):e0160700
Nauta TD et al
2016/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 447
-
文献情報：
Shi M et al. Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship. Am. J. Physiol. Renal Physiol. 2018 04;314(4):F501-F516
Shi M et al
2018/01/01
-
備考：
Species: Mouse -
参照：
- No.： 448
-
文献情報：
Kihira Y et al. Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS ONE 2014;9(4):e93856
Kihira Y et al
2014/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 449
-
文献情報：
Nunomiya A et al. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf) 2016 Jul;
Nunomiya A et al
2016/01/01
-
備考：
-
参照：
- No.： 450
-
文献情報：
Nakayama T et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep 2016 11;6:36478
Nakayama T et al
2016/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 451
-
文献情報：
Wang S et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget 2016 Sep;7(37):58848-58861
Wang S et al
2016/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 452
-
文献情報：
Miess H et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 2018 Oct;37(40):5435-5450
Miess H et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 453
-
文献情報：
Ha JH et al. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics 2016 09;8(9):963-972
Ha JH et al
2016/01/01
-
備考：
-
参照：
- No.： 454
-
文献情報：
Schofield HK et al. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol 2018;5(2):169-185.e2
Schofield HK et al
2018/01/01
-
備考：
Species: Mouse, Applications: IHC -
参照：
- No.： 455
-
文献情報：
Kozlova N et al. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget 2017 Feb;8(6):9885-9898
Kozlova N et al
2017/01/01
-
備考：
-
参照：
- No.： 456
-
文献情報：
Maugeri G et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol 2016;7:139
Maugeri G et al
2016/01/01
-
備考：
WB -
参照：
- No.： 457
-
文献情報：
Regan Anderson TM et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol. Cancer Res. 2018 Nov;16(11):1761-1772
Regan Anderson TM et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 458
-
文献情報：
Bin坦 L et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem. Biol. Interact. 2016 Jan;244:204-14
Bin坦 L et al
2016/01/01
-
備考：
-
参照：
- No.： 459
-
文献情報：
G旦rtz GE et al. Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves" Ophthalmopathy-Implications for Smoking. J. Clin. Endocrinol. Metab. 2016 12;101(12):4834-4842
G旦rtz GE et al
2016/01/01
-
備考：
-
参照：
- No.： 460
-
文献情報：
Terzuoli E et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep;70(17):6837-48
Terzuoli E et al
2010/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 461
-
文献情報：
Yasui T et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports 2017 06;8(6):1743-1756
Yasui T et al
2017/01/01
-
備考：
Species: Human, Applications: -
参照：
- No.： 462
-
文献情報：
Cho DC et al. The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma. Clin. Cancer Res. 2010 Jul;16(14):3628-38
Cho DC et al
2010/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 463
-
文献情報：
Ambrosetti D et al. The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE 2018;13(2):e0193477
Ambrosetti D et al
2018/01/01
-
備考：
Species: Human, Applications: IHC -
参照：
- No.： 464
-
文献情報：
Kowitzke B et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J. Neuropathol. Exp. Neurol. 2016 Sep;75(9):827-42
Kowitzke B et al
2016/01/01
-
備考：
Species: Human, Applications: -
参照：
- No.： 465
-
文献情報：
Wang S et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J. Cell. Mol. Med. 2017 09;21(9):1967-1978
Wang S et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 466
-
文献情報：
Maybin JA et al. Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation. Nat Commun 2018 01;9(1):295
Maybin JA et al
2018/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 467
-
文献情報：
You A et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol 2016 Mar;9:20
You A et al
2016/01/01
-
備考：
WB -
参照：
- No.： 468
-
文献情報：
D"Alessio A et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget 2016 Nov;7(48):78541-78556
D"Alessio A et al
2016/01/01
-
備考：
Species: Human, Applications: IHC -
参照：
- No.： 469
-
文献情報：
Frump AL et al. Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner. Am. J. Respir. Cell Mol. Biol. 2018 07;59(1):114-126
Frump AL et al
2018/01/01
-
備考：
Species: Rat, Applications: -
参照：
- No.： 470
-
文献情報：
Thompson JM et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene 2017 Feb;36(8):1080-1089
Thompson JM et al
2017/01/01
-
備考：
-
参照：
- No.： 471
-
文献情報：
Ke S et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology 2017 01;65(1):134-151
Ke S et al
2017/01/01
-
備考：
-
参照：
- No.： 472
-
文献情報：
Bhanu NV et al. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics 2016 Feb;16(3):448-58
Bhanu NV et al
2016/01/01
-
備考：
-
参照：
- No.： 473
-
文献情報：
Kadam PD et al. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J 2016 Mar;27(3):505
Kadam PD et al
2016/01/01
-
備考：
-
参照：
- No.： 474
-
文献情報：
Samanta D et al. Chemotherapy induces enrichment of CD47<sup>+</sup>/CD73<sup>+</sup>/PDL1<sup>+</sup> immune evasive triple-negative breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2018 02;115(6):E1239-E1248
Samanta D et al
2018/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 475
-
文献情報：
Wu D et al. <i>HIF-1α</i> is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife 2017 05;6
Wu D et al
2017/01/01
-
備考：
Species: Human, Applications: Flow, WB -
参照：
- No.： 476
-
文献情報：
Fujikuni N et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci. 2014 Nov;105(11):1411-20
Fujikuni N et al
2014/01/01
-
備考：
WB -
参照：
- No.： 477
-
文献情報：
Yamamura K et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun 2017 Jan;8:13946
Yamamura K et al
2017/01/01
-
備考：
Species: Mouse, Applications: ICC/IF -
参照：
- No.： 478
-
文献情報：
Ma X et al. Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J. Biol. Chem. 2017 10;292(41):17046-17056
Ma X et al
2017/01/01
-
備考：
Species: Mouse, Applications: -
参照：
- No.： 479
-
文献情報：
Jain CV et al. Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding. Cell Death Differ. 2017 Oct;24(10):1772-1783
Jain CV et al
2017/01/01
-
備考：
WB -
参照：
- No.： 480
-
文献情報：
Sun L et al. Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma. Cancer Sci. 2017 Jul;108(7):1338-1346
Sun L et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 481
-
文献情報：
Thompson JM et al. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol. Cancer Ther. 2018 Aug;17(8):1781-1792
Thompson JM et al
2018/01/01
-
備考：
Species: Mouse, Applications: -
参照：
- No.： 482
-
文献情報：
Okamoto A et al. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep 2017 06;7(1):3816
Okamoto A et al
2017/01/01
-
備考：
-
参照：
- No.： 483
-
文献情報：
Kumar VP et al. PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. Health Phys 2018 07;115(1):65-76
Kumar VP et al
2018/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 484
-
文献情報：
Kim H et al. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Res. 2018 03;20(1):16
Kim H et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 485
-
文献情報：
B辰cker V et al. Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. PLoS ONE 2017;12(12):e0190074
B辰cker V et al
2017/01/01
-
備考：
Species: Mouse, Applications: IHC-P -
参照：
- No.： 486
-
文献情報：
Ho JC et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE 2017;12(11):e0188051
Ho JC et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 487
-
文献情報：
He X et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J. Mol. Cell. Cardiol. 2017 11;112:104-113
He X et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 488
-
文献情報：
Gardner PJ et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep 2017 01;7:40830
Gardner PJ et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 489
-
文献情報：
Pangou E et al. HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia. J. Cell. Sci. 2016 11;129(22):4213-4226
Pangou E et al
2016/01/01
-
備考：
-
参照：
- No.： 490
-
文献情報：
Nam H et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes 2016 06;65(6):1521-33
Nam H et al
2016/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 491
-
文献情報：
Bonora M et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene 2015 Mar;34(12):1608
Bonora M et al
2015/01/01
-
備考：
-
参照：
- No.： 492
-
文献情報：
Hoppe-Seyler K et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2017 02;114(6):E990-E998
Hoppe-Seyler K et al
2017/01/01
-
備考：
Species: Human, Applications: IB -
参照：
- No.： 493
-
文献情報：
Dehn S et al. HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. J. Immunol. 2016 11;197(9):3639-3649
Dehn S et al
2016/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 494
-
文献情報：
Sun W et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep 2017 Aug;7(1):7190
Sun W et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 495
-
文献情報：
Mira E et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nat Commun 2018 02;9(1):575
Mira E et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 496
-
文献情報：
Kuan II et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep 2017 Feb;7:41852
Kuan II et al
2017/01/01
-
備考：
-
参照：
- No.： 497
-
文献情報：
Hoefflin R et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun 2016;7:ncomms11845
Hoefflin R et al
2016/01/01
-
備考：
IHC -
参照：
- No.： 498
-
文献情報：
Luo B et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun 2016;7:12177
Luo B et al
2016/01/01
-
備考：
WB -
参照：
- No.： 499
-
文献情報：
Bin坦 L et al. Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner. Oncotarget 2017 Oct;8(48):83684-83697
Bin坦 L et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 500
-
文献情報：
Timpano S et al. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J. Biol. Chem. 2016 May;291(20):10772-82
Timpano S et al
2016/01/01
-
備考：
-
参照：
- No.： 501
-
文献情報：
Liu Z et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun 2017 09;8(1):584
Liu Z et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 502
-
文献情報：
Mao XG et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma. Oncotarget 2016 Jul;7(30):47808-47820
Mao XG et al
2016/01/01
-
備考：
Species: Human, Applications: ChIP -
参照：
- No.： 503
-
文献情報：
Depner C et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun 2016 Jul;7:12329
Depner C et al
2016/01/01
-
備考：
WB -
参照：
- No.： 504
-
文献情報：
Brooks DL et al. Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models. Methods Mol. Biol. 2018;1742:67-79
Brooks DL et al
2018/01/01
-
備考：
IP -
参照：
- No.： 505
-
文献情報：
Zhang J et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015 Dec;34(23):2953-70
Zhang J et al
2015/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 506
-
文献情報：
Xie L et al. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J. Clin. Invest. 2018 Jun;128(6):2339-2355
Xie L et al
2018/01/01
-
備考：
WB -
参照：
- No.： 507
-
文献情報：
Luo W et al. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget 2016 Feb;7(6):6379-97
Luo W et al
2016/01/01
-
備考：
WB -
参照：
- No.： 508
-
文献情報：
Leinonen H et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum. Mol. Genet. 2016 09;25(17):3810-3823
Leinonen H et al
2016/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 509
-
文献情報：
Casillas AL et al. Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin. Cancer Res. 2018 Jan;24(1):169-180
Casillas AL et al
2018/01/01
-
備考：
Species: Human, Applications: -
参照：
- No.： 510
-
文献情報：
Abdul-Aziz AM et al. HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene 2018 May;37(20):2676-2686
Abdul-Aziz AM et al
2018/01/01
-
備考：
WB -
参照：
- No.： 511
-
文献情報：
Du W et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism. Nat Commun 2017 11;8(1):1769
Du W et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 512
-
文献情報：
Zhang L et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J. Clin. Invest. 2016 12;126(12):4659-4673
Zhang L et al
2016/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 513
-
文献情報：
Wong WJ et al. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J. Invest. Dermatol. 2015 Feb;135(2):454-61
Wong WJ et al
2015/01/01
-
備考：
WB -
参照：
- No.： 514
-
文献情報：
Isono T et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res 2016;6(10):2263-2276
Isono T et al
2016/01/01
-
備考：
Species: Human, Applications: -
参照：
- No.： 515
-
文献情報：
Lee HT et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics 2017;7(4):855-875
Lee HT et al
2017/01/01
-
備考：
Species: Rat, Applications: WB, IHC -
参照：
- No.： 516
-
文献情報：
Strowitzki MJ et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep 2017 Oct;7(1):13151
Strowitzki MJ et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 517
-
文献情報：
Kong KH et al. Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis. Sci Rep 2017 Sep;7(1):11351
Kong KH et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 518
-
文献情報：
Choi YH et al. Myocardial hypertrophy overrides the angiogenic response to hypoxia. PLoS ONE 2008;3(12):e4042
Choi YH et al
2008/01/01
-
備考：
Species: Rabbit, Applications: WB, ELISA -
参照：
- No.： 519
-
文献情報：
Zaini MN et al. Endogenous HIF2A reporter systems for high-throughput functional screening. Sci Rep 2018 Aug;8(1):12063
Zaini MN et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 520
-
文献情報：
Nakazawa MS et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun 2016 Feb;7:10539
Nakazawa MS et al
2016/01/01
-
備考：
WB -
参照：
- No.： 521
-
文献情報：
Senavirathna LK et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep 2018 Feb;8(1):2709
Senavirathna LK et al
2018/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 522
-
文献情報：
Frey JL et al. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res 2014;2:14005
Frey JL et al
2014/01/01
-
備考：
IP -
参照：
- No.： 523
-
文献情報：
Xu M et al. Differential regulation of estrogen in iron metabolism in astrocytes and neurons. J. Cell. Physiol. 2018 Aug;
Xu M et al
2018/01/01
-
備考：
Species: Rat, Applications: WB -
参照：
- No.： 524
-
文献情報：
Luo S et al. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene 2017 06;36(25):3609-3617
Luo S et al
2017/01/01
-
備考：
-
参照：
- No.： 525
-
文献情報：
Yao X et al. <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov 2017 11;7(11):1284-1305
Yao X et al
2017/01/01
-
備考：
WB -
参照：
- No.： 526
-
文献情報：
Liu S et al. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma. Oncotarget 2017 Dec;8(70):115140-115152
Liu S et al
2017/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 527
-
文献情報：
Ho JJD et al. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B. Cell Rep 2018 01;22(1):17-26
Ho JJD et al
2018/01/01
-
備考：
WB -
参照：
- No.： 528
-
文献情報：
Lim E et al. The prognosis outcome of oral squamous cell carcinoma using HIF-2α. J Chin Med Assoc 2017 Oct;80(10):651-656
Lim E et al
2017/01/01
-
備考：
Species: Human, Applications: IHC-P -
参照：
- No.： 529
-
文献情報：
Bテカト淌シrcテシ N et al. Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts. Methods Mol. Biol. 2018;1742:283-300
Bテカト淌シrcテシ N et al
2018/01/01
-
備考：
WB -
参照：
- No.： 530
-
文献情報：
Zhang X et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2014;2:14015
Zhang X et al
2014/01/01
-
備考：
IHC -
参照：
- No.： 531
-
文献情報：
German P et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene 2016 09;35(38):4973-80
German P et al
2016/01/01
-
備考：
-
参照：
- No.： 532
-
文献情報：
Lu H et al. Chemotherapy-Induced Ca<sup>2+</sup> Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep 2017 02;18(8):1946-1957
Lu H et al
2017/01/01
-
備考：
Species: Human, Applications: WB, ChIP -
参照：
- No.： 533
-
文献情報：
Heir P et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J. Biol. Chem. 2016 Apr;291(14):7357-72
Heir P et al
2016/01/01
-
備考：
-
参照：
- No.： 534
-
文献情報：
D鱈az-Trelles R et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun 2016 06;7:12088
D鱈az-Trelles R et al
2016/01/01
-
備考：
WB -
参照：
- No.： 535
-
文献情報：
van Uden P et al. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem. J. 2008 Jun;412(3):477-84
van Uden P et al
2008/01/01
-
備考：
Species: Mouse, Applications: WB -
参照：
- No.： 536
-
文献情報：
Robinson CM et al. Consequences of VHL Loss on Global DNA Methylome. Sci Rep 2018 Feb;8(1):3313
Robinson CM et al
2018/01/01
-
備考：
Species: Human, Applications: GS -
参照：
- No.： 537
-
文献情報：
Dobrynin G et al. KDM4A regulates HIF-1 levels through H3K9me3. Sci Rep 2017 Sep;7(1):11094
Dobrynin G et al
2017/01/01
-
備考：
Species: Human, Applications: WB -
参照：
- No.： 538
-
文献情報：
Cui J et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol. 2016 Jul;
Cui J et al
2016/01/01
-
備考：
Species: Human, Applications: -
参照：
- No.： 539
-
文献情報：
Novianti T et al. Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration. Organogenesis 2019;15(3):69-84
Novianti T et al
2019/01/01
-
備考：
-
参照：
- No.： 540
-
文献情報：
M辿sange P et al. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Oncotarget 20
M辿sange P et al
2014/01/01
-
備考：
-
参照：
- No.： 541
-
文献情報：
Cannito S et al. SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets. Cancers (Basel) 2019 Dec;11(12)
Cannito S et al
2019/01/01
-
備考：
-
参照：
- No.： 542
-
文献情報：
Cohrs G et al. Expression Patterns of Hypoxia-Inducible Factors, Proinflammatory, and Neuroprotective Cytokines in Neuroepithelial Tissues of Lumbar Spinal Lipomas-A Pilot Study. World Neurosurg 2020 09;141:e633-e644
Cohrs G et al
2020/01/01
-
備考：
-
参照：
- No.： 543
-
文献情報：
Qi D et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis 2019 07;10(8):544
Qi D et al
2019/01/01
-
備考：
-
参照：
- No.： 544
-
文献情報：
Schwartz AJ et al. A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling. J Biol Chem 2019 10;294(41):14991-15002
Schwartz AJ et al
2019/01/01
-
備考：
-
参照：
- No.： 545
-
文献情報：
Varghese J et al. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol 2020 Mar;58:126442
Varghese J et al
2020/01/01
-
備考：
-
参照：
- No.： 546
-
文献情報：
Sumi C et al. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. PLoS One 2019;14(4):e0215072
Sumi C et al
2019/01/01
-
備考：
-
参照：
- No.： 547
-
文献情報：
Fabbri L et al. Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients. Theranostics 2020;10(6):2696-2713
Fabbri L et al
2020/01/01
-
備考：
-
参照：
- No.： 548
-
文献情報：
Roelants C et al. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma. Cancers (Basel) 2020 Jan;12(1)
Roelants C et al
2020/01/01
-
備考：
-
参照：
- No.： 549
-
文献情報：
Muenchau S et al. Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression. Mol Cell Biol 2019 07;39(14)
Muenchau S et al
2019/01/01
-
備考：
-
参照：
- No.： 550
-
文献情報：
Shneor D et al. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther 2017 Feb;24(2):64-74
Shneor D et al
2017/01/01
-
備考：
-
参照：
- No.： 551
-
文献情報：
Lee YS et al. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv 2019 07;5(7):eaaw4176
Lee YS et al
2019/01/01
-
備考：
-
参照：
- No.： 552
-
文献情報：
Park KT et al. Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. Biomolecules 2020 04;10(4)
Park KT et al
2020/01/01
-
備考：
-
参照：
- No.： 553
-
文献情報：
Riopel M et al. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism. Mol Metab 2020 11;41:101039
Riopel M et al
2020/01/01
-
備考：
-
参照：
- No.： 554
-
文献情報：
Kurt B et al. Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo. J Am Soc Nephrol 2015 Mar;26(3):587-96
Kurt B et al
2015/01/01
-
備考：
-
参照：
- No.： 555
-
文献情報：
Senavirathna LK et al. Hypoxia and transforming growth factor β1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts. Physiol Rep 2020 01;8(1):e14343
Senavirathna LK et al
2020/01/01
-
備考：
-
参照：
- No.： 556
-
文献情報：
Brown E et al. Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients. FASEB J 2020 03;34(3):3732-3742
Brown E et al
2020/01/01
-
備考：
-
参照：
- No.： 557
-
文献情報：
Sivaraj KK et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. Elife 2020 01;9
Sivaraj KK et al
2020/01/01
-
備考：
-
参照：
- No.： 558
-
文献情報：
Sun X et al. Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α. Am J Respir Cell Mol Biol 2020 07;63(1):92-103
Sun X et al
2020/01/01
-
備考：
-
参照：
- No.： 559
-
文献情報：
Han S et al. The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis. Ther Adv Med Oncol 2019;11:1758835919875851
Han S et al
2019/01/01
-
備考：
-
参照：
- No.： 560
-
文献情報：
van Gisbergen MW et al. Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets. Front Oncol 2020;10:770
van Gisbergen MW et al
2020/01/01
-
備考：
-
参照：
- No.： 561
-
文献情報：
Chen L et al. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma. Theranostics 2020;10(8):3562-3578
Chen L et al
2020/01/01
-
備考：
-
参照：
- No.： 562
-
文献情報：
Gao RY et al. Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology 2020 06;71(6):2105-2117
Gao RY et al
2020/01/01
-
備考：
-
参照：
- No.： 563
-
文献情報：
Sadaghianloo N et al. Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia. J Cell Mol Med 2020 03;24(5):2931-2941
Sadaghianloo N et al
2020/01/01
-
備考：
-
参照：
- No.： 564
-
文献情報：
Jeon GW et al. Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia. Korean J Pediatr 2019 Dec;62(12):444-449
Jeon GW et al
2019/01/01
-
備考：
-
参照：
- No.： 565
-
文献情報：
Hart PC et al. Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep 2019 12;29(12):4086-4098.e6
Hart PC et al
2019/01/01
-
備考：
-
参照：
- No.： 566
-
文献情報：
Park JH et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett 2020 05;478:71-81
Park JH et al
2020/01/01
-
備考：
-
参照：
- No.： 567
-
文献情報：
Gojkovic M et al. Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE). Acta Physiol (Oxf) 2020 Jun;229(2):e13461
Gojkovic M et al
2020/01/01
-
備考：
-
参照：
- No.： 568
-
文献情報：
Chang SH et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun 2019 03;10(1):1442
Chang SH et al
2019/01/01
-
備考：
-
参照：
- No.： 569
-
文献情報：
Shoda C et al. Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy. Nutrients 2020 Apr;12(4)
Shoda C et al
2020/01/01
-
備考：
-
参照：
- No.： 570
-
文献情報：
Morikawa M et al. The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension. Sci Signal 2019 11;12(607)
Morikawa M et al
2019/01/01
-
備考：
-
参照：
- No.： 571
-
文献情報：
Stengel C et al. The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression. Anticancer Res 2015 Oct;35(10):5249-61
Stengel C et al
2015/01/01
-
備考：
-
参照：
- No.： 572
-
文献情報：
Ho JJD et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism. Nat Commun 2020 05;11(1):2677
Ho JJD et al
2020/01/01
-
備考：
-
参照：
- No.： 573
-
文献情報：
Dowdell AS et al. The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis. Mol Biol Cell 2020 09;31(20):2249-2258
Dowdell AS et al
2020/01/01
-
備考：
-
参照：
- No.： 574
-
文献情報：
Yoo HC et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Cell Metab 2020 02;31(2):267-283.e12
Yoo HC et al
2020/01/01
-
備考：
-
参照：
- No.： 575
-
文献情報：
Xie C et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med 2017 Nov;23(11):1298-1308
Xie C et al
2017/01/01
-
備考：
-
参照：
- No.： 576
-
文献情報：
David BT et al. Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord. eNeuro ;7(3)
David BT et al
-
備考：
-
参照：
- No.： 577
-
文献情報：
Wu Y et al. Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells. Mol Cell Biochem 2020 Sep;472(1-2):19-31
Wu Y et al
2020/01/01
-
備考：
-
参照：
- No.： 578
-
文献情報：
Zhang X et al. Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism. Cell Metab 2019 11;30(5):937-951.e5
Zhang X et al
2019/01/01
-
備考：
-
参照：
- No.： 579
-
文献情報：
Kogure A et al. Cancer cells with high-metastatic potential promote a glycolytic shift in activated fibroblasts. PLoS One 2020;15(6):e0234613
Kogure A et al
2020/01/01
-
備考：
-
参照：
- No.： 580
-
文献情報：
Wang YJ et al. Reprogramming of m<sup>6</sup>A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia. RNA Biol 2021 01;18(1):131-143
Wang YJ et al
2021/01/01
-
備考：
-
参照：
- No.： 581
-
文献情報：
Acosta-Iborra B et al. Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis. FASEB J 2020 05;34(5):6654-6674
Acosta-Iborra B et al
2020/01/01
-
備考：
-
参照：
- No.： 582
-
文献情報：
Lu H et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest 2020 09;130(9):4607-4623
Lu H et al
2020/01/01
-
備考：
-
参照：
- No.： 583
-
文献情報：
Yamamoto A et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest 2019 06;129(9):3640-3656
Yamamoto A et al
2019/01/01
-
備考：
-
参照：
- No.： 584
-
文献情報：
Tashiro N et al. Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes. PLoS One 2019;14(11):e0224705
Tashiro N et al
2019/01/01
-
備考：
-
参照：
- No.： 585
-
文献情報：
Seo JB et al. Knockdown of <i>Ant2</i> Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab 2019 01;1(1):86-97
Seo JB et al
2019/01/01
-
備考：
-
参照：
- No.： 586
-
文献情報：
Samanta D et al. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep 2020 08;32(8):108073
Samanta D et al
2020/01/01
-
備考：
-
参照：
- No.： 587
-
文献情報：
Hesse J et al. Normoxic induction of HIF-1α by adenosine-A<sub>2B</sub> R signaling in epicardial stromal cells formed after myocardial infarction. FASEB J 2021 05;35(5):e21517
Hesse J et al
2021/01/01
-
備考：
-
参照：
- No.： 588
-
文献情報：
Romero Y et al. Antitumor Therapy under Hypoxic Microenvironment by the Combination of 2-Methoxyestradiol and Sodium Dichloroacetate on Human Non-Small-Cell Lung Cancer. Oxid Med Cell Longev 2020;2020:3176375
Romero Y et al
2020/01/01
-
備考：
-
参照：
- No.： 589
-
文献情報：
Kida N et al. Cigarette Smoke Extract Activates Hypoxia-Inducible Factors in a Reactive Oxygen Species-Dependent Manner in Stroma Cells from Human Endometrium. Antioxidants (Basel) 2021 Jan;10(1)
Kida N et al
2021/01/01
-
備考：
-
参照：
- No.： 590
-
文献情報：
Jack AR et al. A simple algorithm for evaluating dermatologic disease in critically ill patients: a study based on retrospective review of medical intensive care unit consults. J Am Acad Dermatol 2009 Oct;61(4):728-30
Jack AR et al
2009/01/01
-
備考：
-
参照：
- No.： 591
-
文献情報：
Zhou Y et al. Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. J Mol Med (Berl) 2020 10;98(10):1479-1491
Zhou Y et al
2020/01/01
-
備考：
-
参照：
- No.： 592
-
文献情報：
Gkotinakou IM et al. Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism. Cells 2020 11;9(11)
Gkotinakou IM et al
2020/01/01
-
備考：
-
参照：
- No.： 593
-
文献情報：
Mehibel M et al. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. J Clin Invest 2021 Jun;131(11)
Mehibel M et al
2021/01/01
-
備考：
-
参照：
- No.： 594
-
文献情報：
L坦pez-Rodr鱈guez DM et al. A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency. PLoS Pathog 2019 12;15(12):e1008192
L坦pez-Rodr鱈guez DM et al
2019/01/01
-
備考：
-
参照：
- No.： 595
-
文献情報：
Tiwari A et al. Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Gastroenterology 2020 11;159(5):1882-1897.e5
Tiwari A et al
2020/01/01
-
備考：
-
参照：
- No.： 596
-
文献情報：
Zheng S et al. 2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop. Pharmacol Res 2021 Jul;169:105685
Zheng S et al
2021/01/01
-
備考：
-
参照：
- No.： 597
-
文献情報：
Lee SY et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med 2021 Apr;53(4):591-604
Lee SY et al
2021/01/01
-
備考：
-
参照：
- No.： 598
-
文献情報：
Chen K et al. Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma. Cancer Commun (Lond) 2021 Apr;41(4):316-332
Chen K et al
2021/01/01
-
備考：
-
参照：
- No.： 599
-
文献情報：
Dufies M et al. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Commun Biol 2021 02;4(1):166
Dufies M et al
2021/01/01
-
備考：
-
参照：
- No.： 600
-
文献情報：
Zhang Z et al. Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Cell Metab 2021 Aug;33(8):1624-1639.e9
Zhang Z et al
2021/01/01
-
備考：
-
参照：
- No.： 601
-
文献情報：
Ju C et al. Hypoxia-inducible factor-1α-dependent induction of miR122 enhances hepatic ischemia tolerance. J Clin Invest 2021 Apr;131(7)
Ju C et al
2021/01/01
-
備考：
-
参照：
- No.： 602
-
文献情報：
Kozlova N et al. The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2. Cancer Res 2019 08;79(16):4042-4056
Kozlova N et al
2019/01/01
-
備考：
-
参照：
- No.： 603
-
文献情報：
RawナＶszko-Wieczorek AA et al. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol Cancer Res 2014 Aug;12(8):1112-27
RawナＶszko-Wieczorek AA et al
2014/01/01
-
備考：
-
参照：
- No.： 604
-
文献情報：
Tanimura A et al. MYD88 signals induce tumour-initiating cell generation through the NF-κB-HIF-1α activation cascade. Sci Rep 2021 Feb;11(1):3991
Tanimura A et al
2021/01/01
-
備考：
-
参照：
- No.： 605
-
文献情報：
Ghosh MC et al. Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases. Blood 2021 May;137(18):2509-2519
Ghosh MC et al
2021/01/01
-
備考：
-
参照：
- No.： 606
-
文献情報：
Kim H et al. A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression. Nat Commun 2020 10;11(1):5023
Kim H et al
2020/01/01
-
備考：
-
参照：
- No.： 607
-
文献情報：
Han Q et al. Notch3 is involved in the proliferation of renal cancer cells via regulation of cell cycle progression and HIF-2α. Oncol Lett 2020 Dec;20(6):379
Han Q et al
2020/01/01
-
備考：
-
参照：
- No.： 608
-
文献情報：
Skwarska A et al. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Cell Chem Biol 2021 Apr;
Skwarska A et al
2021/01/01
-
備考：
-
参照：
- No.： 609
-
文献情報：
Wang R et al. Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. Proc Natl Acad Sci U S A 2021 May;118(19)
Wang R et al
2021/01/01
-
備考：
-
参照：
- No.： 610
-
文献情報：
Uba T et al. Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner. Mitochondrion 2021 Jul;59:255-266
Uba T et al
2021/01/01
-
備考：
-
参照：
- No.： 611
-
文献情報：
Sato H et al. Sodium butyrate enhances the growth inhibitory effect of sunitinib in human renal cell carcinoma cells. Oncol Lett 2017 Jul;14(1):937-943
Sato H et al
2017/01/01
-
備考：
-
参照：
- No.： 612
-
文献情報：
Doan H et al. HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer. iScience 2019 Nov;21:509-520
Doan H et al
2019/01/01
-
備考：
-
参照：
- No.： 613
-
文献情報：
He C et al. SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer. Proc Natl Acad Sci U S A 2019 11;116(47):23534-23541
He C et al
2019/01/01
-
備考：
-
参照：
- No.： 614
-
文献情報：
Xie H et al. Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma. Nat Metab 2021 03;3(3):327-336
Xie H et al
2021/01/01
-
備考：
-
参照：
- No.： 615
-
文献情報：
Kleszka K et al. Hypoxia-inducible factor-2α is crucial for proper brain development. Sci Rep 2020 11;10(1):19146
Kleszka K et al
2020/01/01
-
備考：
-
参照：
- No.： 616
-
文献情報：
Bennett LF et al. Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C. Sci Signal 2019 09;12(598)
Bennett LF et al
2019/01/01
-
備考：
-
参照：
- No.： 617
-
文献情報：
Geng G et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. Elife 2021 May;10
Geng G et al
2021/01/01
-
備考：
-
参照：
- No.： 618
-
文献情報：
Shao M et al. Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity. Cell Stem Cell 2021 04;28(4):685-701.e7
Shao M et al
2021/01/01
-
備考：
-
参照：
- No.： 619
-
文献情報：
Li P et al. SIRT1 attenuates renal fibrosis by repressing HIF-2α. Cell Death Discov 2021 Mar;7(1):59
Li P et al
2021/01/01
-
備考：
-
参照：
- No.： 620
-
文献情報：
Firmino NS et al. Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer. Oncoimmunology 2021;10(1):1959978
Firmino NS et al
2021/01/01
-
備考：
Species: Mouse, Applications: Flow -
参照：
- No.： 621
-
文献情報：
DeBerge M et al. Hypoxia-inducible factors individually facilitate inflammatory myeloid metabolism and inefficient cardiac repair. J Exp Med 2021 09;218(9)
DeBerge M et al
2021/01/01
-
備考：
Applications: IHC -
参照：
- No.： 622
-
文献情報：
Wang J et al. Repression of the miR-627-5p by histone deacetylase 3 contributes to hypoxia-induced hepatocellular carcinoma progression. J Cancer 2021;12(17):5320-5330
Wang J et al
2021/01/01
-
備考：
Applications: ChIP -
参照：
- No.： 623
-
文献情報：
Li X et al. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance. Cell Rep 2021 Aug;36(8):109607
Li X et al
2021/01/01
-
備考：
Applications: ChIP, IP, ICC/IF -
参照：
- No.： 624
-
文献情報：
Caielli S et al. Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE. Cell 2021 Aug;184(17):4464-4479.e19
Caielli S et al
2021/01/01
-
備考：
Species: Human, Applications: WB -
参照：