価格表
在庫・価格 ： 2025年08月04日 00時46分 現在
| 商品名 | 商品コード | メーカー | 包装 | 価格 | 在庫 | リスト |
|---|---|---|---|---|---|---|
|
Anti-HIF-2α, Rabbit-Poly <Anti-Hypoxia-Inducible Factor 2α> <Anti-EPAS1> データシート |
NB100-122 |
NOVノバス バイオロジカルス Novus biologicals, LLC |
100 μl | ¥108,000 | 1個 | 追加 |
在庫・価格 ： 2025年08月04日 00時46分 現在
使用文献
| No. | 文献情報 | 備考 | 参照 |
|---|---|---|---|
| 1 |
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| 31 |
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| 33 |
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| 35 |
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| 36 |
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| 39 |
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| 40 |
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| 41 |
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| 45 |
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Yamashita T et al. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood 2008 Aug;112(4):1482-92 Yamashita T et al 2008/01/01 |
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Meyuhas R et al. A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Mol. Cancer Res. 2008 Sep;6(9):1397-409 Meyuhas R et al 2008/01/01 |
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Ginouv竪s A et al. PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc. Natl. Acad. Sci. U.S.A. 2008 Mar;105(12):4745-50 Ginouv竪s A et al 2008/01/01 |
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| 110 |
Lee K et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc. Natl. Acad. Sci. U.S.A. 2009 Feb;106(7):2353-8 Lee K et al 2009/01/01 |
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Arab A et al. Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity. J. Pharmacol. Exp. Ther. 2008 May;325(2):417-24 Arab A et al 2008/01/01 |
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Lee K A et al. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol. Cancer Res. 2008 May;6(5):829-42 Lee K A et al 2008/01/01 |
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Xie L et al. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am. J. Physiol., Cell Physiol. 2011 Jun;300(6):C1298-305 Xie L et al 2011/01/01 |
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Brown ST et al. Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am. J. Physiol., Cell Physiol. 2008 Jun;294(6):C1305-12 Brown ST et al 2008/01/01 |
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Walter A et al. Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. J. Pharmacol. Exp. Ther. 2009 May;329(2):699-707 Walter A et al 2009/01/01 |
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Martin SK et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica 2010 May;95(5):776-84 Martin SK et al 2010/01/01 |
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Fang HY et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009 Jul;114(4):844-59 Fang HY et al 2009/01/01 |
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Sakoda Y et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice. J. Clin. Invest. 2011 Dec;121(12):4810-9 Sakoda Y et al 2011/01/01 |
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Hughes MD et al. HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer Cell Int. 2007;7:13 Hughes MD et al 2007/01/01 |
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| 126 |
Wacker I et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol. Cell. Biol. 2009 Apr;29(7):1707-18 Wacker I et al 2009/01/01 |
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Krieg AJ et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol. Cell. Biol. 2010 Jan;30(1):344-53 Krieg AJ et al 2010/01/01 |
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| 128 |
van Hagen M et al. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res. 2010 Apr;38(6):1922-31 van Hagen M et al 2010/01/01 |
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| 129 |
Zhou W et al. Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS ONE 2011;6(11):e27460 Zhou W et al 2011/01/01 |
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| 130 |
Hubbi ME et al. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J. Biol. Chem. 2012 Feb;287(9):6139-49 Hubbi ME et al 2012/01/01 |
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Zhang H et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec;105(50):19579-86 Zhang H et al 2008/01/01 |
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Kojima I et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J. Am. Soc. Nephrol. 2007 Apr;18(4):1218-26 Kojima I et al 2007/01/01 |
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Place TL et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE 2011;6(1):e14617 Place TL et al 2011/01/01 |
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| 134 |
Trollmann R et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008 Dec;295(6):R1973-81 Trollmann R et al 2008/01/01 |
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| 135 |
Sears JE et al. Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc. Natl. Acad. Sci. U.S.A. 2008 Dec;105(50):19898-903 Sears JE et al 2008/01/01 |
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| 136 |
Mahajan S et al. Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis 2008 Sep;29(9):1734-41 Mahajan S et al 2008/01/01 |
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| 137 |
Shen GM et al. Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. Biochem. J. 2012 Jan;441(2):675-83 Shen GM et al 2012/01/01 |
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| 138 |
Dutta D et al. Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. J. Biol. Chem. 2008 Sep;283(37):25404-13 Dutta D et al 2008/01/01 |
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| 139 |
Chen C et al. Association of elevated HIF-2α levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma. Ann. Surg. Oncol. 2011 Aug;18(8):2364-72 Chen C et al 2011/01/01 |
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| 140 |
Zhang H et al. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011 Jul;9(7):e1001112 Zhang H et al 2011/01/01 |
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| 141 |
Luu VD et al. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin. Cancer Res. 2009 May;15(10):3297-304 Luu VD et al 2009/01/01 |
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| 142 |
Bruning U et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol. Cell. Biol. 2011 Oct;31(19):4087-96 Bruning U et al 2011/01/01 |
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| 143 |
Graven KK et al. HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Biochim. Biophys. Acta 2003 Apr;1626(1-3):10-8 Graven KK et al 2003/01/01 |
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| 144 |
Metallo CM et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2012 Jan;481(7381):380-4 Metallo CM et al 2012/01/01 |
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| 145 |
Franovic A et al. Human cancers converge at the HIF-2alpha oncogenic axis. Proc. Natl. Acad. Sci. U.S.A. 2009 Dec;106(50):21306-11 Franovic A et al 2009/01/01 |
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| 146 |
Smith K et al. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005 Jun;65(12):5221-30 Smith K et al 2005/01/01 |
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| 147 |
Lee K et al. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc. Natl. Acad. Sci. U.S.A. 2009 Oct;106(42):17910-5 Lee K et al 2009/01/01 |
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| 148 |
Wang H et al. Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells. Mutat. Res. 2011 Aug;723(2):171-6 Wang H et al 2011/01/01 |
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| 149 |
Ad N et al. Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ann. Thorac. Surg. 2001 Sep;72(3):688-93 Ad N et al 2001/01/01 |
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| 150 |
Takeda K et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood 2008 Mar;111(6):3229-35 Takeda K et al 2008/01/01 |
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| 151 |
Minamishima YA et al. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol. Cell. Biol. 2009 Nov;29(21):5729-41 Minamishima YA et al 2009/01/01 |
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| 152 |
Kanno T et al. JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Oncogene 2012 Jun;31(25):3098-110 Kanno T et al 2012/01/01 |
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| 153 |
Luo W et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011 May;145(5):732-44 Luo W et al 2011/01/01 |
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| 154 |
Matak P et al. Lack of iron-related phenotype in Sp6 intestinal knockout mice. Blood Cells Mol. Dis. 2011 Jun;47(1):46-9 Matak P et al 2011/01/01 |
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| 155 |
Zhou G et al. Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J. 2008 May;22(5):1335-42 Zhou G et al 2008/01/01 |
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| 156 |
Kim J et al. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology 2009 Jul;150(7):3392-400 Kim J et al 2009/01/01 |
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| 157 |
Ma Y et al. Prostate cancer cell lines under hypoxia exhibit greater stem-like properties. PLoS ONE 2011;6(12):e29170 Ma Y et al 2011/01/01 |
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| 158 |
Regazzetti C et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 2009 Jan;58(1):95-103 Regazzetti C et al 2009/01/01 |
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| 159 |
Nagao K et al. HIF-2 directly activates CD82 gene expression in endothelial cells. Biochem. Biophys. Res. Commun. 2011 Apr;407(1):260-5 Nagao K et al 2011/01/01 |
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| 160 |
Neal CS et al. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med 2010;8:64 Neal CS et al 2010/01/01 |
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| 161 |
Pan Y et al. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 2004 Jun;23(29):4975-83 Pan Y et al 2004/01/01 |
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| 162 |
Korgaonkar SN et al. HIV-1 upregulates VEGF in podocytes. J. Am. Soc. Nephrol. 2008 May;19(5):877-83 Korgaonkar SN et al 2008/01/01 |
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| 163 |
Xia G et al. Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology 2002 May;59(5):774-8 Xia G et al 2002/01/01 |
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| 164 |
Ren H et al. A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α. Invest. Ophthalmol. Vis. Sci. 2011 May;52(6):3112-8 Ren H et al 2011/01/01 |
Applications: WB, Species: Mouse | |
| 165 |
Valsecchi V et al. NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke 2011 Mar;42(3):754-63 Valsecchi V et al 2011/01/01 |
Applications: WB, Species: Human | |
| 166 |
Poitz DM et al. OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway. Basic Res. Cardiol. 2011 Sep;106(5):761-72 Poitz DM et al 2011/01/01 |
Applications: WB, Species: Human | |
| 167 |
Heddleston JM et al. Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ. 2012 Mar;19(3):428-39 Heddleston JM et al 2012/01/01 |
Applications: WB, Species: Human | |
| 168 |
Zhang H et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012 Apr;31(14):1757-70 Zhang H et al 2012/01/01 |
Applications: WB, Species: Human | |
| 169 |
Schrobback K et al. Effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Eng Part A 2012 May;18(9-10):920-33 Schrobback K et al 2012/01/01 |
Applications: IHC-Fr, IF, Species: Human | |
| 170 |
Ding Z et al. Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. J Biomol Screen 2012 Jun;17(5):572-80 Ding Z et al 2012/01/01 |
Applications: WB, Species: Human | |
| 171 |
Salman S et al. Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Am. J. Physiol., Cell Physiol. 2012 May;302(10):C1531-8 Salman S et al 2012/01/01 |
Applications: WB, Species: Rat | |
| 172 |
Xu Y et al. EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells. PLoS ONE 2012;7(5):e37765 Xu Y et al 2012/01/01 |
Applications: WB, Species: Human | |
| 173 |
Zhou Q et al. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization. FEBS Lett. 2012 May;586(10):1510-5 Zhou Q et al 2012/01/01 |
Applications: WB, Species: Human | |
| 174 |
Uniacke J et al. An oxygen-regulated switch in the protein synthesis machinery. Nature 2012 Jun;486(7401):126-9 Uniacke J et al 2012/01/01 |
Applications: WB, Species: Human | |
| 175 |
Park SJ et al. L-2-Oxothiazolidine-4-Carboxylic Acid or α-Lipoic Acid Attenuates Airway Remodeling: Involvement of Nuclear Factor-κB (NF-κB), Nuclear Factor Erythroid 2p45-Related Factor-2 (Nrf2), and Hypoxia-Inducible Factor (HIF). Int Park SJ et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 176 |
Chintala S et al. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. BMC Cancer 2012;12:293 Chintala S et al 2012/01/01 |
Species: Human, Applications: WB | |
| 177 |
Park SJ et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm. Res. 2012 Oct;61(10):1069-83 Park SJ et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 178 |
Bardella C et al. Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Mol. Cell. Biol. 2012 Aug;32(15):3081-94 Bardella C et al 2012/01/01 |
Species: Human, Applications: WB | |
| 179 |
Lee SW et al. Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Mol Med 2012 Sep;4(9):924-38 Lee SW et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 180 |
Jham BC et al. Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma. PLoS ONE 2011;6(4):e19103 Jham BC et al 2011/01/01 |
Species: Mouse, Human, Applications: IHC, WB | |
| 181 |
Pourvali K et al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α. FEBS Lett. 2012 Jul;586(16):2423-7 Pourvali K et al 2012/01/01 |
Species: Human, Applications: WB | |
| 182 |
Boysen G et al. Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia 2012 Jun;14(6):535-46 Boysen G et al 2012/01/01 |
Species: Human, Applications: WB | |
| 183 |
Nayak BK et al. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene 2012 Aug; Nayak BK et al 2012/01/01 |
Species: Human, Applications: WB | |
| 184 |
Wong CC et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc. Natl. Acad. Sci. U.S.A. 2011 Sep;108(39):16369-74 Wong CC et al 2011/01/01 |
Species: Human, Applications: WB | |
| 185 |
Chen R et al. The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling. J. Biol. Chem. 2012 Aug;287(36):30800-11 Chen R et al 2012/01/01 |
Species: Human, Applications: WB | |
| 186 |
Krishnamachary B et al. Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer. PLoS ONE 2012;7(8):e44078 Krishnamachary B et al 2012/01/01 |
Species: Human, Applications: WB | |
| 187 |
. ; |
Species: Mouse, Applications: IP, ChIP, WB | |
| 188 |
Anderson ER et al. The Hypoxia-Inducible Factor-C/EBPα Axis Controls Ethanol-Mediated Hepcidin Repression. Mol. Cell. Biol. 2012 Oct;32(19):4068-77 Anderson ER et al 2012/01/01 |
Species: Mouse, Applications: WB | |
| 189 |
Ho JJ et al. Functional importance of dicer protein in the adaptive cellular response to hypoxia. J. Biol. Chem. 2012 Aug;287(34):29003-20 Ho JJ et al 2012/01/01 |
Species: Human, Mouse, Applications: WB | |
| 190 |
Hubbi ME et al. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol. Cell 2011 Jun;42(5):700-12 Hubbi ME et al 2011/01/01 |
Species: Human, Applications: WB | |
| 191 |
Sciorra VA et al. Suppression of glioma progression by egln3. PLoS ONE 2012;7(8):e40053 Sciorra VA et al 2012/01/01 |
Species: Human, Rat, Applications: WB | |
| 192 |
Chiavarina B et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 2012 Sep;11(17):3280-9 Chiavarina B et al 2012/01/01 |
Applications: WB, ICC/IF | |
| 193 |
Hatano N et al. Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J. Biol. Chem. 2012 Sep;287(38):31962 Hatano N et al 2012/01/01 |
Applications: WB | |
| 194 |
Salnikov AV et al. Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential. PLoS ONE 2012;7(9):e46391 Salnikov AV et al 2012/01/01 |
Applications: IHC, ICC/IF | |
| 195 |
Higashimura Y et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 2011 May;509(1):1-8 Higashimura Y et al 2011/01/01 |
Applications: WB | |
| 196 |
Barshishat-Kupper M et al. Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Exp. Hematol. 2011 Mar;39(3):293-304 Barshishat-Kupper M et al 2011/01/01 |
Applications: WB | |
| 197 |
Pawlus MR et al. Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2α (HIF2α) Cooperatively Activate HIF2 Target Genes during Hypoxia. Mol. Cell. Biol. 2012 Nov;32(22):4595-610 Pawlus MR et al 2012/01/01 |
Applications: WB, ChIP | |
| 198 |
Lee J et al. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling. J. Cell. Biochem. 2012 Dec;113(12):3681-91 Lee J et al 2012/01/01 |
Species: Human, Applications: WB | |
| 199 |
Razorenova OV et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc. Natl. Acad. Sci. U.S.A. 2011 Feb;108(5):1931-6 Razorenova OV et al 2011/01/01 |
Species: Human, Applications: WB | |
| 200 |
Yamasaki T et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Cancer Sci. 2012 Nov;103(11):2027-37 Yamasaki T et al 2012/01/01 |
Species: Human, Applications: WB | |
| 201 |
Croci DO et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J. Exp. Med. 2012 Oct;209(11):1985-2000 Croci DO et al 2012/01/01 |
Species: Human, Applications: WB | |
| 202 |
Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010 May;30(5):669-82 Copple BL 2010/01/01 |
Species: Mouse, Applications: WB | |
| 203 |
Gimm T et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010 Nov;24(11):4443-58 Gimm T et al 2010/01/01 |
Species: Human, Applications: WB | |
| 204 |
Emerling BM et al. Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc. Natl. Acad. Sci. U.S.A. 2013 Feb;110(9):3483-8 Emerling BM et al 2013/01/01 |
Species: Human, Applications: ChIP | |
| 205 |
Xu Y et al. The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 2013 Jan;266(2):187-97 Xu Y et al 2013/01/01 |
Species: Human, Applications: WB | |
| 206 |
Neelam S et al. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol. Vis. 2013;19:1-15 Neelam S et al 2013/01/01 |
Species: Human, Applications: WB | |
| 207 |
Storti P et al. Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia 2013 Jan; Storti P et al 2013/01/01 |
Species: Human, Applications: WB | |
| 208 |
Pang Y et al. The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. Toxicol. Lett. 2013 Apr;218(2):105-17 Pang Y et al 2013/01/01 |
Species: Human, Applications: WB | |
| 209 |
Gilkes DM et al. Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts. J. Biol. Chem. 2013 Apr;288(15):10819-29 Gilkes DM et al 2013/01/01 |
Species: Human, Applications: WB | |
| 210 |
Veeranna RP et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. J. Virol. 2012 Jan;86(2):1097-108 Veeranna RP et al 2012/01/01 |
Species: Human, Applications: WB, ChIP | |
| 211 |
Casagrande S et al. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. J. Pathol. 2013 Mar;229(4):525-34 Casagrande S et al 2013/01/01 |
Species: Human, Applications: WB | |
| 212 |
Choi HJ et al. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS ONE 2013;8(2):e56949 Choi HJ et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 213 |
Shimanishi M et al. Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia. J. Oral Pathol. Med. 2012 Dec; Shimanishi M et al 2012/01/01 |
Species: Human, Applications: WB | |
| 214 |
Gonzalez-Flores A et al. Interaction between PARP-1 and HIF-2α in the hypoxic response. Oncogene 2013 Mar; Gonzalez-Flores A et al 2013/01/01 |
Species: Mouse, Human, Applications: WB, IP | |
| 215 |
Vanharanta S et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 2013 Jan;19(1):50-6 Vanharanta S et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 216 |
Maruyama T et al. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PLoS ONE 2013;8(2):e56984 Maruyama T et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 217 |
Wu DC et al. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS ONE 2010;5(6):e11303 Wu DC et al 2010/01/01 |
Species: Mouse, Applications: ChIP | |
| 218 |
Gilkes D et al. Procollagen Lysyl Hydroxylase 2 is Essential for Breast Cancer Metastasis. Mol. Cancer Res. 2013 Feb; Gilkes D et al 2013/01/01 |
Applications: WB | |
| 219 |
Finger EC et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2013 Feb; Finger EC et al 2013/01/01 |
Species: Human, Applications: WB | |
| 220 |
Zhang Y et al. Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Sci. 2013 Apr;104(4):416-22 Zhang Y et al 2013/01/01 |
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| 221 |
Matak P et al. Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice. PLoS ONE 2013;8(3):e59538 Matak P et al 2013/01/01 |
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| 222 |
Mohlin S et al. HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 2013 Mar;15(3):328-34 Mohlin S et al 2013/01/01 |
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Copple BL et al. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009 Aug;29(7):1010-21 Copple BL et al 2009/01/01 |
Species: Mouse, Applications: WB, ICC/IF | |
| 224 |
Parks SK et al. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J. Cell. Physiol. 2013 Sep;228(9):1854-62 Parks SK et al 2013/01/01 |
Species: Human, Applications: WB | |
| 225 |
van de Sluis B et al. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J. Clin. Invest. 2010 Jun;120(6):2119-30 van de Sluis B et al 2010/01/01 |
Species: Human, Applications: WB | |
| 226 |
Gilkes DM et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013 Jun;73(11):3285-96 Gilkes DM et al 2013/01/01 |
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| 227 |
Rajakumar A et al. Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. Placenta 2008 Mar;29(3):290-9 Rajakumar A et al 2008/01/01 |
Species: Human, Applications: WB | |
| 228 |
Bohensky J et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009 May;60(5):1406-15 Bohensky J et al 2009/01/01 |
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| 229 |
Mao XG et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro-oncology 2013 Jul;15(7):865-79 Mao XG et al 2013/01/01 |
Species: Human, Applications: WB, ChIP | |
| 230 |
Fu L et al. Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer Res. 2013 May;73(9):2916-25 Fu L et al 2013/01/01 |
Species: Mouse, Applications: IHC | |
| 231 |
Luo B et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis. Biochim. Biophys. Acta 2013 Aug;1832(8):1260-70 Luo B et al 2013/01/01 |
Species: Rat, Applications: WB | |
| 232 |
Pawlus MR et al. STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013 Apr; Pawlus MR et al 2013/01/01 |
Species: Human, Applications: WB | |
| 233 |
Ben-Shoshan J et al. Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties. Stem Cells 2008 Oct;26(10):2634-43 Ben-Shoshan J et al 2008/01/01 |
Species: Human, Applications: ELISA | |
| 234 |
Xie L et al. Transcription Factors Sp1 and Hif2α Mediate Induction of the Copper-transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells during Hypoxia. J. Biol. Chem. 2013 Aug;288(33):23943-52 Xie L et al 2013/01/01 |
Species: Rat, Applications: WB, ChIP | |
| 235 |
Forristal CE et al. Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells. PLoS ONE 2013;8(5):e62507 Forristal CE et al 2013/01/01 |
Species: Human, Applications: ChIP | |
| 236 |
Finley DS et al. Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report. Urol. Oncol. ;29(1):85-9 Finley DS et al |
Species: Human, Applications: IHC-P | |
| 237 |
Poitz DM et al. Regulation of the Hif-system by micro-RNA 17 and 20a - Role during monocyte-to-macrophage differentiation. Mol. Immunol. 2013 Jul;56(4):442-451 Poitz DM et al 2013/01/01 |
Species: Human, Applications: WB | |
| 238 |
Kim M et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013 Sep;5(9):1415-30 Kim M et al 2013/01/01 |
Species: Mouse, Applications: IHC-P | |
| 239 |
Rasbach KA et al. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc. Natl. Acad. Sci. U.S.A. 2010 Dec;107(50):21866-71 Rasbach KA et al 2010/01/01 |
Species: Mouse, Applications: WB | |
| 240 |
Wong WJ et al. MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Mol. Cell. Biol. 2013 Sep;33(17):3494-504 Wong WJ et al 2013/01/01 |
Species: Human, Applications: WB | |
| 241 |
Ikeda J et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2013 Jun;2(3):e000178 Ikeda J et al 2013/01/01 |
Species: Human, Applications: WB | |
| 242 |
You Q et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem. Pharmacol. 2013 Sep;86(6):836-43 You Q et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 243 |
Sato Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 2013 Aug;45(8):860-7 Sato Y et al 2013/01/01 |
Species: Human, Applications: IHC | |
| 244 |
Brackmann FA et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res. 2013 Sep;1531:65-74 Brackmann FA et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 245 |
Hubbi ME et al. Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors. J. Biol. Chem. 2013 Jul;288(29):20768-75 Hubbi ME et al 2013/01/01 |
Species: Human, Applications: WB | |
| 246 |
Xiang L et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J. Mol. Med. 2013 Nov; Xiang L et al 2013/01/01 |
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| 247 |
Yuan HT et al. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am. J. Pathol. 2003 Dec;163(6):2289-301 Yuan HT et al 2003/01/01 |
Species: Mouse, Applications: IHC-P, WB | |
| 248 |
Luo X et al. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells. Biochim. Biophys. Acta 2014 Jan;1840(1):106-12 Luo X et al 2014/01/01 |
Species: Human, Applications: WB | |
| 249 |
Natsuizaka M et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012 Jun;26(6):2620-30 Natsuizaka M et al 2012/01/01 |
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| 250 |
Befani C et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int. J. Biochem. Cell Biol. 2013 Nov;45(11):2359-68 Befani C et al 2013/01/01 |
Species: Human, Applications: WB | |
| 251 |
Qing G et al. Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res. 2010 Dec;70(24):10351-61 Qing G et al 2010/01/01 |
Species: Mouse, Human, Applications: WB, IHC | |
| 252 |
Thapa RJ et al. NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Mol. Cancer Ther. 2013 Aug;12(8):1568-78 Thapa RJ et al 2013/01/01 |
Species: Human, Applications: WB | |
| 253 |
Regan Anderson TM et al. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 2013 Sep;73(18):5810-20 Regan Anderson TM et al 2013/01/01 |
Species: Human, Applications: WB | |
| 254 |
Takeda K et al. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007 Aug;116(7):774-81 Takeda K et al 2007/01/01 |
Species: Mouse, Applications: WB | |
| 255 |
Wei K et al. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat. Med. 2013 Oct;19(10):1331-7 Wei K et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 256 |
Hu CJ et al. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007 Nov;18(11):4528-42 Hu CJ et al 2007/01/01 |
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| 257 |
Doedens AL et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat. Immunol. 2013 Nov;14(11):1173-82 Doedens AL et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 258 |
Kerkel辰 R et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol. Cell. Biol. 2013 Aug;33(16):3321-9 Kerkel辰 R et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 259 |
Eckle T et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep;11(9):e1001665 Eckle T et al 2013/01/01 |
Species: Human, Applications: WB | |
| 260 |
Duan LJ et al. Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am. J. Pathol. 2011 Apr;178(4):1881-90 Duan LJ et al 2011/01/01 |
Species: Mouse, Applications: WB | |
| 261 |
Costa B et al. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J. 2010 Aug;24(8):2680-8 Costa B et al 2010/01/01 |
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| 262 |
Cowburn AS et al. Epidermal Deletion of HIF-2α Stimulates Wound Closure. J. Invest. Dermatol. 2013 Sep; Cowburn AS et al 2013/01/01 |
Species: Human, Applications: WB | |
| 263 |
Pawlus MR et al. STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE 2013;8(8):e72358 Pawlus MR et al 2013/01/01 |
Species: Human, Applications: ChIP, WB | |
| 264 |
Razorenova OV et al. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol. Cell. Biol. 2014 Feb;34(4):739-51 Razorenova OV et al 2014/01/01 |
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| 265 |
Proper SP et al. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol. Sci. 2014 Feb;137(2):447-57 Proper SP et al 2014/01/01 |
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| 266 |
Pasupuleti V et al. Dysregulated D-dopachrome Tautomerase, a Hypoxia-inducible Factor-dependent Gene, Cooperates with Macrophage Migration Inhibitory Factor in Renal Tumorigenesis. J. Biol. Chem. 2014 Feb;289(6):3713-23 Pasupuleti V et al 2014/01/01 |
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| 267 |
Selvarajah J et al. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell Death Dis 2013;4:e865 Selvarajah J et al 2013/01/01 |
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| 268 |
Bocca C et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin. Ther. Targets 2014 Feb;18(2):121-35 Bocca C et al 2014/01/01 |
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| 269 |
Xu Z et al. MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α. PLoS ONE 2013;8(10):e77890 Xu Z et al 2013/01/01 |
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| 270 |
Scholz CC et al. Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc. Natl. Acad. Sci. U.S.A. 2013 Nov;110(46):18490-5 Scholz CC et al 2013/01/01 |
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| 271 |
Gilkes DM et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):E384-93 Gilkes DM et al 2014/01/01 |
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Poitz DM et al. Regulation of the HIF-system in human macrophages--differential regulation of HIF-α subunits under sustained hypoxia. Mol. Immunol. 2014 Feb;57(2):226-35 Poitz DM et al 2014/01/01 |
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| 273 |
Hanna C et al. Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis. Am. J. Physiol. Renal Physiol. 2013 Nov;305(9):F1323-31 Hanna C et al 2013/01/01 |
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| 274 |
Glover LE et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc. Natl. Acad. Sci. U.S.A. 2013 Dec;110(49):19820-5 Glover LE et al 2013/01/01 |
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| 275 |
Zhu J et al. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter. J. Lipid Res. 2014 Mar;55(3):431-42 Zhu J et al 2014/01/01 |
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| 276 |
Kumar V et al. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur. J. Immunol. 2014 Mar;44(3):831-41 Kumar V et al 2014/01/01 |
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| 277 |
Goetze O et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology 2013 Dec;58(6):2153-62 Goetze O et al 2013/01/01 |
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| 278 |
Place TL et al. Prolyl-4-Hydroxylase 3 (PHD3) Expression Is Downregulated during Epithelial-to-Mesenchymal Transition. PLoS ONE 2013;8(12):e83021 Place TL et al 2013/01/01 |
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| 279 |
Chen Z et al. Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS ONE 2013;8(12):e80337 Chen Z et al 2013/01/01 |
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| 280 |
Takano N et al. Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression. Biochem. J. 2014 Mar;458(2):203-11 Takano N et al 2014/01/01 |
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| 281 |
Cowburn AS et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc. Natl. Acad. Sci. U.S.A. 2013 Oct;110(43):17570-5 Cowburn AS et al 2013/01/01 |
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| 282 |
Gomes AP et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013 Dec;155(7):1624-38 Gomes AP et al 2013/01/01 |
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| 283 |
Nanduri J et al. Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia. PLoS ONE 2013;8(10):e75838 Nanduri J et al 2013/01/01 |
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| 284 |
Mangiavini L et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev. Biol. 2014 Sep;393(1):124-36 Mangiavini L et al 2014/01/01 |
Species: Mouse, Applications: IHC-P | |
| 285 |
Slominski A et al. The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014 Dec;563:79-93 Slominski A et al 2014/01/01 |
Species: Human, Hamster, Applications: WB | |
| 286 |
Bordji K et al. Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells. FEBS J. 2014 Dec;281(23):5220-36 Bordji K et al 2014/01/01 |
Species: Human, Applications: WB, GS | |
| 287 |
Liu XD et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene 2014 Jul; Liu XD et al 2014/01/01 |
Species: Human, Applications: WB, IP, Co-IP | |
| 288 |
El Assar M et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br. J. Pharmacol. 2014 Nov; El Assar M et al 2014/01/01 |
Species: Rat, Applications: WB | |
| 289 |
Petruzzelli R et al. HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element. PLoS ONE 2014;9(10):e108309 Petruzzelli R et al 2014/01/01 |
Species: Human, Applications: ICC/IF, ChIP | |
| 290 |
Wojciak-Stothard B et al. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation 2014 Apr;129(17):1770-80 Wojciak-Stothard B et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 291 |
Furcht CM et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J. Cell. Sci. 2014 Aug;127(Pt 16):3555-67 Furcht CM et al 2014/01/01 |
Species: Human, Applications: WB | |
| 292 |
Kono K et al. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev. Biol. 2014 Oct;394(1):142-55 Kono K et al 2014/01/01 |
Species: Human, Hamster, Applications: WB | |
| 293 |
Rana S et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB J. 2014 Oct;28(10):4324-34 Rana S et al 2014/01/01 |
Species: Human, Applications: WB | |
| 294 |
Takano N et al. Decreased Expression of Cystathionine β-Synthase Promotes Glioma Tumorigenesis. Mol. Cancer Res. 2014 Oct;12(10):1398-406 Takano N et al 2014/01/01 |
Species: Human, Applications: WB | |
| 295 |
Su EJ et al. Impaired Fetoplacental Angiogenesis in Growth-Restricted Fetuses With Abnormal Umbilical Artery Doppler Velocimetry Is Mediated by Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT). J. Clin. Endocrinol. Metab. 2015 Jan;100(1):E30-40 Su EJ et al 2015/01/01 |
Species: Human, Applications: WB | |
| 296 |
Chaturvedi P et al. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc. Natl. Acad. Sci. U.S.A. 2014 May;111(20):E2120-9 Chaturvedi P et al 2014/01/01 |
Species: Human, Applications: ChIP | |
| 297 |
Huang YH et al. Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol. Hum. Reprod. 2014 Jun;20(6):526-37 Huang YH et al 2014/01/01 |
Species: Mouse, Applications: ICC/IF, WB | |
| 298 |
Nagaya Y et al. Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α. Eur. J. Neurosci. 2014 Dec;40(11):3620-6 Nagaya Y et al 2014/01/01 |
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| 299 |
Qin N et al. Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int. J. Cancer 2014 Nov;135(9):2054-64 Qin N et al 2014/01/01 |
Species: Human, Mouse, Applications: IHC-P, WB | |
| 300 |
Yoshizawa S et al. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater 2014 Jun;10(6):2834-42 Yoshizawa S et al 2014/01/01 |
Species: Human, Applications: WB | |
| 301 |
Hubbi ME et al. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression. Proc. Natl. Acad. Sci. U.S.A. 2014 Aug;111(32):E3325-34 Hubbi ME et al 2014/01/01 |
Species: Human, Applications: WB | |
| 302 |
Hou P et al. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2. PLoS ONE 2014;9(11):e113865 Hou P et al 2014/01/01 |
Species: Human, Applications: WB | |
| 303 |
Samanta D et al. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 2014 Dec;111(50):E5429-38 Samanta D et al 2014/01/01 |
Species: Human, Applications: WB | |
| 304 |
Chen Z et al. EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300. Mol. Cell. Biol. 2014 Mar;34(6):1085-99 Chen Z et al 2014/01/01 |
Species: Human, Applications: WB | |
| 305 |
Chen SJ et al. A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth through Hypoxia-inducible Factor (HIF)-1/2α. J. Biol. Chem. 2014 Dec;289(52):36284-302 Chen SJ et al 2014/01/01 |
Species: Human, Applications: WB | |
| 306 |
Duan LJ et al. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am. J. Pathol. 2014 Apr;184(4):1240-50 Duan LJ et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 307 |
Zhang J et al. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet. Mol. Res. 2014;13(4):9324-35 Zhang J et al 2014/01/01 |
Species: Human, Applications: WB | |
| 308 |
Muz B et al. Hypoxia Promotes Dissemination and Colonization in New Bone Marrow Niches in Waldenstrom's Macroglobulinemia. Mol. Cancer Res. 2014 Sep; Muz B et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 309 |
Qi Y et al. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2014 Nov; Qi Y et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 310 |
Ding Z et al. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun;74(11):3127-36 Ding Z et al 2014/01/01 |
Species: Human, Applications: WB | |
| 311 |
Zhou Y et al. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am. J. Pathol. 2014 Dec;184(12):3321-31 Zhou Y et al 2014/01/01 |
Species: Human, Applications: IHC | |
| 312 |
Henze AT et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun 2014;5:5582 Henze AT et al 2014/01/01 |
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| 313 |
Heyboer M et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res 2014 May;12(3):638-45 Heyboer M et al 2014/01/01 |
Species: Human, Applications: FLOW | |
| 314 |
Weisel FC et al. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling. Circulation 2014 Apr;129(14):1510-23 Weisel FC et al 2014/01/01 |
Species: Mouse, Human, Applications: ChIP | |
| 315 |
Wilkinson N et al. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood 2013 Aug;122(9):1658-68 Wilkinson N et al 2013/01/01 |
Species: Mouse, Applications: WB | |
| 316 |
Wu R et al. Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. J. Clin. Invest. 2014 Nov;124(11):4795-806 Wu R et al 2014/01/01 |
Species: Human, Applications: ChIP | |
| 317 |
Asnaghi L et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE 2014;9(8):e105372 Asnaghi L et al 2014/01/01 |
Species: Human, Applications: WB | |
| 318 |
Arreola A et al. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PLoS ONE 2014;9(5):e98705 Arreola A et al 2014/01/01 |
Species: Mouse, Applications: ICC/IF | |
| 319 |
Hu H et al. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget 2014 Oct;5(19):8853-68 Hu H et al 2014/01/01 |
Species: Human, Applications: ChIP, WB | |
| 320 |
Lalev辿e S et al. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. Cell Death Dis 2014;5:e1408 Lalev辿e S et al 2014/01/01 |
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| 321 |
Li B et al. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 2014 Sep;513(7517):251-5 Li B et al 2014/01/01 |
Species: Human, Applications: WB, IP | |
| 322 |
Lian G et al. Protein profiling of Helicobacter pylori-associated gastric cancer. Am. J. Pathol. 2014 May;184(5):1343-54 Lian G et al 2014/01/01 |
Species: Human, Applications: WB | |
| 323 |
Yoo S et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015 Jan;11(1):e1004898 Yoo S et al 2015/01/01 |
Species: Human, Applications: WB | |
| 324 |
Koh MY et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015 Jan;75(2):316-29 Koh MY et al 2015/01/01 |
Species: Human, Applications: WB | |
| 325 |
Neelam S et al. Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol. Vis. 2014;20:1758-75 Neelam S et al 2014/01/01 |
Species: Human, Applications: WB | |
| 326 |
Singleton DC et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene 2014 Dec;0 Singleton DC et al 2014/01/01 |
Species: Human, Applications: WB | |
| 327 |
Nozawa-Suzuki N et al. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer. Biochem. Biophys. Res. Commun. 2015 Feb;457(4):706-11 Nozawa-Suzuki N et al 2015/01/01 |
Species: Human, Applications: WB | |
| 328 |
Tsuboi I et al. Impaired expression of HIF -2α induces compensatory expression of HIF-1α for the recovery from anemia. J. Cell. Physiol. 2015 Jan; Tsuboi I et al 2015/01/01 |
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Xiang L et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget 2014 Dec;5(24):12509-27 Xiang L et al 2014/01/01 |
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Gerovac BJ et al. Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner. Am. J. Respir. Cell Mol. Biol. 2014 Oct;51(4):516-25 Gerovac BJ et al 2014/01/01 |
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Jimenez K et al. Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J. Thromb. Haemost. 2015 Feb; Jimenez K et al 2015/01/01 |
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| 332 |
Doonachar A et al. Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines. Cancer Cell Int. 2015;15:23 Doonachar A et al 2015/01/01 |
Species: Human, Applications: WB | |
| 333 |
Matak P et al. Myeloid HIF-1 Is Protective in Helicobacter pylori-Mediated Gastritis. J. Immunol. 2015 Apr;194(7):3259-66 Matak P et al 2015/01/01 |
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Salman S et al. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A. Am. J. Physiol., Cell Physiol. 2014 Aug;307(3):C266-77 Salman S et al 2014/01/01 |
Species: Rat, | |
| 335 |
Cotroneo E et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ. Res. 2015 May;116(10):1680-90 Cotroneo E et al 2015/01/01 |
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Zeng H et al. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J. Cell. Mol. Med. 2015 Mar; Zeng H et al 2015/01/01 |
Species: Mouse, Applications: WB | |
| 337 |
Yoshizawa S et al. Role of magnesium ions on osteogenic response in bone marrow stromal cells. Connect. Tissue Res. 2014 Aug;55 Suppl 1:155-9 Yoshizawa S et al 2014/01/01 |
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Fiorito V et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1. Biochim. Biophys. Acta 2014;1839(4):259-64 Fiorito V et al 2014/01/01 |
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Chen R et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE 2015;10(2):e0116515 Chen R et al 2015/01/01 |
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| 340 |
McMurray F et al. Pharmacological inhibition of FTO. PLoS ONE 2015;10(4):e0121829 McMurray F et al 2015/01/01 |
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Cassinat B et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell Cassinat B et al 2011/01/01 |
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| 342 |
Luo T et al. Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. Clin. Vaccine Imm Luo T et al 2010/01/01 |
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| 343 |
Zagzag D et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005 Jul;65(14):6178-88 Zagzag D et al 2005/01/01 |
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Zimmer M et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010 Apr;70(8):3071-9 Zimmer M et al 2010/01/01 |
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Wu S et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther 2015;15(3):313-25 Wu S et al 2015/01/01 |
Species: Mouse | |
| 346 |
Forristal CE et al. Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia 2015 Oct;29(10):2075-85 Forristal CE et al 2015/01/01 |
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Koizume S et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol. Cancer 2015;14:77 Koizume S et al 2015/01/01 |
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Petrella BL et al. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005 Feb;24(6):1043-52 Petrella BL et al 2005/01/01 |
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Monsef N et al. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate 2007 Aug;67(11):1219-29 Monsef N et al 2007/01/01 |
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Lu H et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc. Natl. Acad. Sci. U.S.A. 2015 Aug;112(33):E4600-9 Lu H et al 2015/01/01 |
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Hickey MM et al. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J. Clin. Invest. 2007 Dec;117(12):3879-89 Hickey MM et al 2007/01/01 |
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| 352 |
Chiatar SS et al. Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation. Cell Dev Biol 2013 Aug;2 Chiatar SS et al 2013/01/01 |
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Liu YL et al. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol. Ther. 2006 Oct;5(10):1320-6 Liu YL et al 2006/01/01 |
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Pareek TK et al. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 2010 Oct;207(11):2507-19 Pareek TK et al 2010/01/01 |
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Shao J et al. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell. Dev. Biol. Anim. 2015 Sep;51(8):808-14 Shao J et al 2015/01/01 |
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Lin AE et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015 Apr;11(4):e1004818 Lin AE et al 2015/01/01 |
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H旦gel H et al. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol. Cancer 2015;14:143 H旦gel H et al 2015/01/01 |
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Rajakumar A et al. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta 2004 Nov;25(10):763-9 Rajakumar A et al 2004/01/01 |
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Tanaka T et al. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem. J. 2009 Nov;424(1):143-51 Tanaka T et al 2009/01/01 |
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Moslehi J et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation 2010 Sep;122(10):1004-16 Moslehi J et al 2010/01/01 |
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Lee S et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 2005 Aug;8(2):155-67 Lee S et al 2005/01/01 |
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Ramakrishnan SK et al. Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul;112(28):E3738-47 Ramakrishnan SK et al 2015/01/01 |
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Monzon FA et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod. Pathol. 2011 Nov;24(11):1470-9 Monzon FA et al 2011/01/01 |
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Liu MY et al. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res. 2003 May;63(10):2675-80 Liu MY et al 2003/01/01 |
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Chua RA et al. Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2. J. Am. Acad. Dermatol. 2009 Oct;61(4):730-2 Chua RA et al 2009/01/01 |
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Matsuyama T et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur. J. Pharmacol. 2015 Aug;761:189-98 Matsuyama T et al 2015/01/01 |
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Przybytkowski E et al. Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability. FEBS J. 2009 Nov;276(21):6204-17 Przybytkowski E et al 2009/01/01 |
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Wu S et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol. Ther. 2008 Jul;16(7):1227-34 Wu S et al 2008/01/01 |
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Sanchez M et al. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat. Struct. Mol. Biol. 2007 May;14(5):420-6 Sanchez M et al 2007/01/01 |
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Maltepe E et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development 2005 Aug;132(15):3393-403 Maltepe E et al 2005/01/01 |
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Qiu B et al. HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov 2015 Jun;5(6):652-67 Qiu B et al 2015/01/01 |
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Evens AM et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br. J. Haematol. 2008 May;141(5):676-80 Evens AM et al 2008/01/01 |
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Chiabrando D et al. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol. Dis. 2012 Aug; Chiabrando D et al 2012/01/01 |
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Irwin R et al. Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype. J. Cell. Biochem. 2007 Feb;100(3):762-72 Irwin R et al 2007/01/01 |
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Highet AR et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur. J. Cell Biol. 2015 Dec;94(12):589-602 Highet AR et al 2015/01/01 |
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Regan Anderson TM et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016 Mar;76(6):1653-63 Regan Anderson TM et al 2016/01/01 |
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Pramono A et al. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop. Ann. N. Y. Acad. Sci. 2016 Jul;1375(1):38-51 Pramono A et al 2016/01/01 |
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Zeng H et al. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep 2016;6:20931 Zeng H et al 2016/01/01 |
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Glasmacher S. [Recommendation for vaccination against polio]. Gesundheitswesen 2014 Feb;76(2):71 Glasmacher S 2014/01/01 |
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Russell RC et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat. Med. 2011 Jul;17(7):845-53 Russell RC et al 2011/01/01 |
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Lee CM et al. VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo. Oncogene 2009 Apr;28(14):1694-705 Lee CM et al 2009/01/01 |
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Mohanty SK. Multidimensional poverty and child survival in India. PLoS ONE 2011;6(10):e26857 Mohanty SK 2011/01/01 |
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Yang Q et al. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Prot Yang Q et al 2018/01/01 |
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| 431 |
Gastelum G et al. Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PLoS ONE 2017;12(12):e01 Gastelum G et al 2017/01/01 |
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Dai Z et al. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α. Circulatio Dai Z et al 2016/01/01 |
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Huh YH et al. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res. Ther. 2015 Oct;17:302 Huh YH et al 2015/01/01 |
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Ariazi JL et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J. Pharmacol. Exp. Ther. 2017 Dec;363(3):336-347 Ariazi JL et al 2017/01/01 |
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Woo JK et al. Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Cancer Prev Res (Phila) 2009 Apr;2(4):361-9 Woo JK et al 2009/01/01 |
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Prakash H et al. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep 2016 08;6:31490 Prakash H et al 2016/01/01 |
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Ferecatu I et al. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation. PLoS ONE 2018;13(3):e0194782 Ferecatu I et al 2018/01/01 |
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| 438 |
Tsang KM et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α. Stem Cell Reports 2017 Sep;9(3):796-806 Tsang KM et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 439 |
Tang H et al. Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition. Am. J. Physiol. Lung Cell Mol. Physiol. 2018 02;314(2):L256-L275 Tang H et al 2018/01/01 |
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| 440 |
Megele R et al. Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series. Oncol Lett 2018 Nov;16(5):5813-5822 Megele R et al 2018/01/01 |
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| 441 |
Hoang NT et al. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci. 2016 Aug;107(8):1151-8 Hoang NT et al 2016/01/01 |
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| 442 |
Christinat Y et al. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics 2016 07;32(14):2111-9 Christinat Y et al 2016/01/01 |
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| 443 |
Landau D et al. The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia. PLoS ONE 2018;13(5):e0196684 Landau D et al 2018/01/01 |
Species: Rat, Applications: WB | |
| 444 |
Gstalder C et al. FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Mol. Cancer Ther. 2016 10;15(10):2465-2474 Gstalder C et al 2016/01/01 |
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| 445 |
Salati S et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget 2017 Jul;8(30):49451-49469 Salati S et al 2017/01/01 |
Species: Human, Applications: WB | |
| 446 |
Nauta TD et al. HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE 2016;11(8):e0160700 Nauta TD et al 2016/01/01 |
Species: Human, Applications: WB | |
| 447 |
Shi M et al. Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship. Am. J. Physiol. Renal Physiol. 2018 04;314(4):F501-F516 Shi M et al 2018/01/01 |
Species: Mouse | |
| 448 |
Kihira Y et al. Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS ONE 2014;9(4):e93856 Kihira Y et al 2014/01/01 |
Species: Mouse, Applications: WB | |
| 449 |
Nunomiya A et al. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf) 2016 Jul; Nunomiya A et al 2016/01/01 |
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| 450 |
Nakayama T et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep 2016 11;6:36478 Nakayama T et al 2016/01/01 |
Species: Human, Applications: WB | |
| 451 |
Wang S et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget 2016 Sep;7(37):58848-58861 Wang S et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 452 |
Miess H et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 2018 Oct;37(40):5435-5450 Miess H et al 2018/01/01 |
Species: Human, Applications: WB | |
| 453 |
Ha JH et al. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics 2016 09;8(9):963-972 Ha JH et al 2016/01/01 |
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| 454 |
Schofield HK et al. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol 2018;5(2):169-185.e2 Schofield HK et al 2018/01/01 |
Species: Mouse, Applications: IHC | |
| 455 |
Kozlova N et al. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget 2017 Feb;8(6):9885-9898 Kozlova N et al 2017/01/01 |
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| 456 |
Maugeri G et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol 2016;7:139 Maugeri G et al 2016/01/01 |
WB | |
| 457 |
Regan Anderson TM et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol. Cancer Res. 2018 Nov;16(11):1761-1772 Regan Anderson TM et al 2018/01/01 |
Species: Human, Applications: WB | |
| 458 |
Bin坦 L et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem. Biol. Interact. 2016 Jan;244:204-14 Bin坦 L et al 2016/01/01 |
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| 459 |
G旦rtz GE et al. Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking. J. Clin. Endocrinol. Metab. 2016 12;101(12):4834-4842 G旦rtz GE et al 2016/01/01 |
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Terzuoli E et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010 Sep;70(17):6837-48 Terzuoli E et al 2010/01/01 |
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| 461 |
Yasui T et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports 2017 06;8(6):1743-1756 Yasui T et al 2017/01/01 |
Species: Human, Applications: | |
| 462 |
Cho DC et al. The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma. Clin. Cancer Res. 2010 Jul;16(14):3628-38 Cho DC et al 2010/01/01 |
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| 463 |
Ambrosetti D et al. The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE 2018;13(2):e0193477 Ambrosetti D et al 2018/01/01 |
Species: Human, Applications: IHC | |
| 464 |
Kowitzke B et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J. Neuropathol. Exp. Neurol. 2016 Sep;75(9):827-42 Kowitzke B et al 2016/01/01 |
Species: Human, Applications: | |
| 465 |
Wang S et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J. Cell. Mol. Med. 2017 09;21(9):1967-1978 Wang S et al 2017/01/01 |
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| 466 |
Maybin JA et al. Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation. Nat Commun 2018 01;9(1):295 Maybin JA et al 2018/01/01 |
Species: Mouse, Applications: WB | |
| 467 |
You A et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol 2016 Mar;9:20 You A et al 2016/01/01 |
WB | |
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D'Alessio A et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget 2016 Nov;7(48):78541-78556 D'Alessio A et al 2016/01/01 |
Species: Human, Applications: IHC | |
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Frump AL et al. Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner. Am. J. Respir. Cell Mol. Biol. 2018 07;59(1):114-126 Frump AL et al 2018/01/01 |
Species: Rat, Applications: | |
| 470 |
Thompson JM et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene 2017 Feb;36(8):1080-1089 Thompson JM et al 2017/01/01 |
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| 471 |
Ke S et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology 2017 01;65(1):134-151 Ke S et al 2017/01/01 |
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| 472 |
Bhanu NV et al. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics 2016 Feb;16(3):448-58 Bhanu NV et al 2016/01/01 |
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| 473 |
Kadam PD et al. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J 2016 Mar;27(3):505 Kadam PD et al 2016/01/01 |
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| 474 |
Samanta D et al. Chemotherapy induces enrichment of CD47<sup>+</sup>/CD73<sup>+</sup>/PDL1<sup>+</sup> immune evasive triple-negative breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2018 02;115(6):E1239-E1248 Samanta D et al 2018/01/01 |
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| 475 |
Wu D et al. <i>HIF-1α</i> is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife 2017 05;6 Wu D et al 2017/01/01 |
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Fujikuni N et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci. 2014 Nov;105(11):1411-20 Fujikuni N et al 2014/01/01 |
WB | |
| 477 |
Yamamura K et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun 2017 Jan;8:13946 Yamamura K et al 2017/01/01 |
Species: Mouse, Applications: ICC/IF | |
| 478 |
Ma X et al. Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J. Biol. Chem. 2017 10;292(41):17046-17056 Ma X et al 2017/01/01 |
Species: Mouse, Applications: | |
| 479 |
Jain CV et al. Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding. Cell Death Differ. 2017 Oct;24(10):1772-1783 Jain CV et al 2017/01/01 |
WB | |
| 480 |
Sun L et al. Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma. Cancer Sci. 2017 Jul;108(7):1338-1346 Sun L et al 2017/01/01 |
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| 481 |
Thompson JM et al. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol. Cancer Ther. 2018 Aug;17(8):1781-1792 Thompson JM et al 2018/01/01 |
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| 482 |
Okamoto A et al. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep 2017 06;7(1):3816 Okamoto A et al 2017/01/01 |
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| 483 |
Kumar VP et al. PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. Health Phys 2018 07;115(1):65-76 Kumar VP et al 2018/01/01 |
Species: Mouse, Applications: WB | |
| 484 |
Kim H et al. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Res. 2018 03;20(1):16 Kim H et al 2018/01/01 |
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| 485 |
B辰cker V et al. Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. PLoS ONE 2017;12(12):e0190074 B辰cker V et al 2017/01/01 |
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| 486 |
Ho JC et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE 2017;12(11):e0188051 Ho JC et al 2017/01/01 |
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| 487 |
He X et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J. Mol. Cell. Cardiol. 2017 11;112:104-113 He X et al 2017/01/01 |
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| 488 |
Gardner PJ et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep 2017 01;7:40830 Gardner PJ et al 2017/01/01 |
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| 489 |
Pangou E et al. HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia. J. Cell. Sci. 2016 11;129(22):4213-4226 Pangou E et al 2016/01/01 |
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| 490 |
Nam H et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes 2016 06;65(6):1521-33 Nam H et al 2016/01/01 |
Species: Human, Applications: WB | |
| 491 |
Bonora M et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene 2015 Mar;34(12):1608 Bonora M et al 2015/01/01 |
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| 492 |
Hoppe-Seyler K et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2017 02;114(6):E990-E998 Hoppe-Seyler K et al 2017/01/01 |
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| 493 |
Dehn S et al. HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. J. Immunol. 2016 11;197(9):3639-3649 Dehn S et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 494 |
Sun W et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep 2017 Aug;7(1):7190 Sun W et al 2017/01/01 |
Species: Human, Applications: WB | |
| 495 |
Mira E et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nat Commun 2018 02;9(1):575 Mira E et al 2018/01/01 |
Species: Human, Applications: WB | |
| 496 |
Kuan II et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep 2017 Feb;7:41852 Kuan II et al 2017/01/01 |
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| 497 |
Hoefflin R et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun 2016;7:ncomms11845 Hoefflin R et al 2016/01/01 |
IHC | |
| 498 |
Luo B et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun 2016;7:12177 Luo B et al 2016/01/01 |
WB | |
| 499 |
Bin坦 L et al. Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner. Oncotarget 2017 Oct;8(48):83684-83697 Bin坦 L et al 2017/01/01 |
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| 500 |
Timpano S et al. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J. Biol. Chem. 2016 May;291(20):10772-82 Timpano S et al 2016/01/01 |
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| 501 |
Liu Z et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun 2017 09;8(1):584 Liu Z et al 2017/01/01 |
Species: Human, Applications: WB | |
| 502 |
Mao XG et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma. Oncotarget 2016 Jul;7(30):47808-47820 Mao XG et al 2016/01/01 |
Species: Human, Applications: ChIP | |
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Depner C et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun 2016 Jul;7:12329 Depner C et al 2016/01/01 |
WB | |
| 504 |
Brooks DL et al. Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models. Methods Mol. Biol. 2018;1742:67-79 Brooks DL et al 2018/01/01 |
IP | |
| 505 |
Zhang J et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015 Dec;34(23):2953-70 Zhang J et al 2015/01/01 |
Species: Human, Applications: WB | |
| 506 |
Xie L et al. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J. Clin. Invest. 2018 Jun;128(6):2339-2355 Xie L et al 2018/01/01 |
WB | |
| 507 |
Luo W et al. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget 2016 Feb;7(6):6379-97 Luo W et al 2016/01/01 |
WB | |
| 508 |
Leinonen H et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum. Mol. Genet. 2016 09;25(17):3810-3823 Leinonen H et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 509 |
Casillas AL et al. Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin. Cancer Res. 2018 Jan;24(1):169-180 Casillas AL et al 2018/01/01 |
Species: Human, Applications: | |
| 510 |
Abdul-Aziz AM et al. HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene 2018 May;37(20):2676-2686 Abdul-Aziz AM et al 2018/01/01 |
WB | |
| 511 |
Du W et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism. Nat Commun 2017 11;8(1):1769 Du W et al 2017/01/01 |
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| 512 |
Zhang L et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J. Clin. Invest. 2016 12;126(12):4659-4673 Zhang L et al 2016/01/01 |
Species: Mouse, Applications: WB | |
| 513 |
Wong WJ et al. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J. Invest. Dermatol. 2015 Feb;135(2):454-61 Wong WJ et al 2015/01/01 |
WB | |
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Isono T et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res 2016;6(10):2263-2276 Isono T et al 2016/01/01 |
Species: Human, Applications: | |
| 515 |
Lee HT et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics 2017;7(4):855-875 Lee HT et al 2017/01/01 |
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Strowitzki MJ et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep 2017 Oct;7(1):13151 Strowitzki MJ et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 517 |
Kong KH et al. Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis. Sci Rep 2017 Sep;7(1):11351 Kong KH et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 518 |
Choi YH et al. Myocardial hypertrophy overrides the angiogenic response to hypoxia. PLoS ONE 2008;3(12):e4042 Choi YH et al 2008/01/01 |
Species: Rabbit, Applications: WB, ELISA | |
| 519 |
Zaini MN et al. Endogenous HIF2A reporter systems for high-throughput functional screening. Sci Rep 2018 Aug;8(1):12063 Zaini MN et al 2018/01/01 |
Species: Human, Applications: WB | |
| 520 |
Nakazawa MS et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun 2016 Feb;7:10539 Nakazawa MS et al 2016/01/01 |
WB | |
| 521 |
Senavirathna LK et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep 2018 Feb;8(1):2709 Senavirathna LK et al 2018/01/01 |
Species: Human, Applications: WB | |
| 522 |
Frey JL et al. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res 2014;2:14005 Frey JL et al 2014/01/01 |
IP | |
| 523 |
Xu M et al. Differential regulation of estrogen in iron metabolism in astrocytes and neurons. J. Cell. Physiol. 2018 Aug; Xu M et al 2018/01/01 |
Species: Rat, Applications: WB | |
| 524 |
Luo S et al. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene 2017 06;36(25):3609-3617 Luo S et al 2017/01/01 |
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Yao X et al. <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov 2017 11;7(11):1284-1305 Yao X et al 2017/01/01 |
WB | |
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Liu S et al. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma. Oncotarget 2017 Dec;8(70):115140-115152 Liu S et al 2017/01/01 |
Species: Mouse, Applications: WB | |
| 527 |
Ho JJD et al. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B. Cell Rep 2018 01;22(1):17-26 Ho JJD et al 2018/01/01 |
WB | |
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Lim E et al. The prognosis outcome of oral squamous cell carcinoma using HIF-2α. J Chin Med Assoc 2017 Oct;80(10):651-656 Lim E et al 2017/01/01 |
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Bテカト淌シrcテシ N et al. Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts. Methods Mol. Biol. 2018;1742:283-300 Bテカト淌シrcテシ N et al 2018/01/01 |
WB | |
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Zhang X et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2014;2:14015 Zhang X et al 2014/01/01 |
IHC | |
| 531 |
German P et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene 2016 09;35(38):4973-80 German P et al 2016/01/01 |
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| 532 |
Lu H et al. Chemotherapy-Induced Ca<sup>2+</sup> Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep 2017 02;18(8):1946-1957 Lu H et al 2017/01/01 |
Species: Human, Applications: WB, ChIP | |
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Heir P et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J. Biol. Chem. 2016 Apr;291(14):7357-72 Heir P et al 2016/01/01 |
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| 534 |
D鱈az-Trelles R et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun 2016 06;7:12088 D鱈az-Trelles R et al 2016/01/01 |
WB | |
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van Uden P et al. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem. J. 2008 Jun;412(3):477-84 van Uden P et al 2008/01/01 |
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Robinson CM et al. Consequences of VHL Loss on Global DNA Methylome. Sci Rep 2018 Feb;8(1):3313 Robinson CM et al 2018/01/01 |
Species: Human, Applications: GS | |
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Dobrynin G et al. KDM4A regulates HIF-1 levels through H3K9me3. Sci Rep 2017 Sep;7(1):11094 Dobrynin G et al 2017/01/01 |
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| 538 |
Cui J et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol. 2016 Jul; Cui J et al 2016/01/01 |
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| 539 |
Novianti T et al. Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration. Organogenesis 2019;15(3):69-84 Novianti T et al 2019/01/01 |
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M辿sange P et al. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Oncotarget 20 M辿sange P et al 2014/01/01 |
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Cannito S et al. SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets. Cancers (Basel) 2019 Dec;11(12) Cannito S et al 2019/01/01 |
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Cohrs G et al. Expression Patterns of Hypoxia-Inducible Factors, Proinflammatory, and Neuroprotective Cytokines in Neuroepithelial Tissues of Lumbar Spinal Lipomas-A Pilot Study. World Neurosurg 2020 09;141:e633-e644 Cohrs G et al 2020/01/01 |
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Qi D et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis 2019 07;10(8):544 Qi D et al 2019/01/01 |
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Schwartz AJ et al. A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling. J Biol Chem 2019 10;294(41):14991-15002 Schwartz AJ et al 2019/01/01 |
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Varghese J et al. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol 2020 Mar;58:126442 Varghese J et al 2020/01/01 |
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Sumi C et al. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. PLoS One 2019;14(4):e0215072 Sumi C et al 2019/01/01 |
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Fabbri L et al. Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients. Theranostics 2020;10(6):2696-2713 Fabbri L et al 2020/01/01 |
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Roelants C et al. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma. Cancers (Basel) 2020 Jan;12(1) Roelants C et al 2020/01/01 |
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Muenchau S et al. Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression. Mol Cell Biol 2019 07;39(14) Muenchau S et al 2019/01/01 |
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Shneor D et al. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther 2017 Feb;24(2):64-74 Shneor D et al 2017/01/01 |
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Ren H et al
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備考：
Applications: WB, Species: Mouse -
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Applications: WB, Species: Human -
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Applications: WB, Species: Human -
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Applications: WB, Species: Human -
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文献情報：
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Applications: WB, Species: Human -
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文献情報：
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Schrobback K et al
2012/01/01
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備考：
Applications: IHC-Fr, IF, Species: Human -
参照：
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文献情報：
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Ding Z et al
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備考：
Applications: WB, Species: Human -
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備考：
Applications: WB, Species: Rat -
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文献情報：
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備考：
Applications: WB, Species: Human -
参照：
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文献情報：
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Applications: WB, Species: Human -
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文献情報：
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Applications: WB, Species: Human -
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文献情報：
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備考：
Species: Mouse, Applications: WB -
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備考：
Species: Human, Applications: WB -
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文献情報：
Park SJ et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm. Res. 2012 Oct;61(10):1069-83
Park SJ et al
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備考：
Species: Mouse, Applications: WB -
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文献情報：
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備考：
Species: Human, Applications: WB -
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文献情報：
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Lee SW et al
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備考：
Species: Mouse, Applications: WB -
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備考：
Species: Mouse, Human, Applications: IHC, WB -
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Species: Human, Applications: WB -
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Species: Human, Applications: WB -
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Nayak BK et al. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene 2012 Aug;
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備考：
Species: Human, Applications: WB -
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文献情報：
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Species: Human, Applications: WB -
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文献情報：
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Species: Human, Applications: WB -
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Krishnamachary B et al
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備考：
Species: Human, Applications: WB -
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文献情報：
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備考：
Species: Mouse, Applications: IP, ChIP, WB -
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2012/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
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文献情報：
Ho JJ et al. Functional importance of dicer protein in the adaptive cellular response to hypoxia. J. Biol. Chem. 2012 Aug;287(34):29003-20
Ho JJ et al
2012/01/01
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備考：
Species: Human, Mouse, Applications: WB -
参照：
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文献情報：
Hubbi ME et al. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol. Cell 2011 Jun;42(5):700-12
Hubbi ME et al
2011/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Sciorra VA et al. Suppression of glioma progression by egln3. PLoS ONE 2012;7(8):e40053
Sciorra VA et al
2012/01/01
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備考：
Species: Human, Rat, Applications: WB -
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文献情報：
Chiavarina B et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 2012 Sep;11(17):3280-9
Chiavarina B et al
2012/01/01
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備考：
Applications: WB, ICC/IF -
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- No.： 193
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文献情報：
Hatano N et al. Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J. Biol. Chem. 2012 Sep;287(38):31962
Hatano N et al
2012/01/01
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備考：
Applications: WB -
参照：
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文献情報：
Salnikov AV et al. Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential. PLoS ONE 2012;7(9):e46391
Salnikov AV et al
2012/01/01
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備考：
Applications: IHC, ICC/IF -
参照：
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文献情報：
Higashimura Y et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch. Biochem. Biophys. 2011 May;509(1):1-8
Higashimura Y et al
2011/01/01
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備考：
Applications: WB -
参照：
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文献情報：
Barshishat-Kupper M et al. Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Exp. Hematol. 2011 Mar;39(3):293-304
Barshishat-Kupper M et al
2011/01/01
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備考：
Applications: WB -
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文献情報：
Pawlus MR et al. Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2α (HIF2α) Cooperatively Activate HIF2 Target Genes during Hypoxia. Mol. Cell. Biol. 2012 Nov;32(22):4595-610
Pawlus MR et al
2012/01/01
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備考：
Applications: WB, ChIP -
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文献情報：
Lee J et al. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling. J. Cell. Biochem. 2012 Dec;113(12):3681-91
Lee J et al
2012/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Razorenova OV et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc. Natl. Acad. Sci. U.S.A. 2011 Feb;108(5):1931-6
Razorenova OV et al
2011/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Yamasaki T et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Cancer Sci. 2012 Nov;103(11):2027-37
Yamasaki T et al
2012/01/01
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備考：
Species: Human, Applications: WB -
参照：
- No.： 201
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文献情報：
Croci DO et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J. Exp. Med. 2012 Oct;209(11):1985-2000
Croci DO et al
2012/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010 May;30(5):669-82
Copple BL
2010/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
- No.： 203
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文献情報：
Gimm T et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010 Nov;24(11):4443-58
Gimm T et al
2010/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Emerling BM et al. Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc. Natl. Acad. Sci. U.S.A. 2013 Feb;110(9):3483-8
Emerling BM et al
2013/01/01
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備考：
Species: Human, Applications: ChIP -
参照：
- No.： 205
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文献情報：
Xu Y et al. The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Toxicol. Appl. Pharmacol. 2013 Jan;266(2):187-97
Xu Y et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
- No.： 206
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文献情報：
Neelam S et al. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol. Vis. 2013;19:1-15
Neelam S et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Storti P et al. Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia 2013 Jan;
Storti P et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Pang Y et al. The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. Toxicol. Lett. 2013 Apr;218(2):105-17
Pang Y et al
2013/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Gilkes DM et al. Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by Inducing P4HA1, P4HA2, and PLOD2 Expression in Fibroblasts. J. Biol. Chem. 2013 Apr;288(15):10819-29
Gilkes DM et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Veeranna RP et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. J. Virol. 2012 Jan;86(2):1097-108
Veeranna RP et al
2012/01/01
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備考：
Species: Human, Applications: WB, ChIP -
参照：
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文献情報：
Casagrande S et al. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. J. Pathol. 2013 Mar;229(4):525-34
Casagrande S et al
2013/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Choi HJ et al. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS ONE 2013;8(2):e56949
Choi HJ et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
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文献情報：
Shimanishi M et al. Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia. J. Oral Pathol. Med. 2012 Dec;
Shimanishi M et al
2012/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Gonzalez-Flores A et al. Interaction between PARP-1 and HIF-2α in the hypoxic response. Oncogene 2013 Mar;
Gonzalez-Flores A et al
2013/01/01
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備考：
Species: Mouse, Human, Applications: WB, IP -
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文献情報：
Vanharanta S et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 2013 Jan;19(1):50-6
Vanharanta S et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
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文献情報：
Maruyama T et al. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PLoS ONE 2013;8(2):e56984
Maruyama T et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
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文献情報：
Wu DC et al. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS ONE 2010;5(6):e11303
Wu DC et al
2010/01/01
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備考：
Species: Mouse, Applications: ChIP -
参照：
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文献情報：
Gilkes D et al. Procollagen Lysyl Hydroxylase 2 is Essential for Breast Cancer Metastasis. Mol. Cancer Res. 2013 Feb;
Gilkes D et al
2013/01/01
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備考：
Applications: WB -
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文献情報：
Finger EC et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene 2013 Feb;
Finger EC et al
2013/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Zhang Y et al. Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Sci. 2013 Apr;104(4):416-22
Zhang Y et al
2013/01/01
-
備考：
Species: Human, Applications: IHC-P, WB -
参照：
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文献情報：
Matak P et al. Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice. PLoS ONE 2013;8(3):e59538
Matak P et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
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文献情報：
Mohlin S et al. HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia 2013 Mar;15(3):328-34
Mohlin S et al
2013/01/01
-
備考：
Species: Human, Applications: IHC-P -
参照：
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文献情報：
Copple BL et al. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009 Aug;29(7):1010-21
Copple BL et al
2009/01/01
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備考：
Species: Mouse, Applications: WB, ICC/IF -
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文献情報：
Parks SK et al. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J. Cell. Physiol. 2013 Sep;228(9):1854-62
Parks SK et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
van de Sluis B et al. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J. Clin. Invest. 2010 Jun;120(6):2119-30
van de Sluis B et al
2010/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Gilkes DM et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013 Jun;73(11):3285-96
Gilkes DM et al
2013/01/01
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備考：
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参照：
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文献情報：
Rajakumar A et al. Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. Placenta 2008 Mar;29(3):290-9
Rajakumar A et al
2008/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Bohensky J et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009 May;60(5):1406-15
Bohensky J et al
2009/01/01
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備考：
Species: Human, Mouse, Applications: IHC-P, ICC/IF -
参照：
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文献情報：
Mao XG et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro-oncology 2013 Jul;15(7):865-79
Mao XG et al
2013/01/01
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備考：
Species: Human, Applications: WB, ChIP -
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文献情報：
Fu L et al. Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer Res. 2013 May;73(9):2916-25
Fu L et al
2013/01/01
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備考：
Species: Mouse, Applications: IHC -
参照：
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文献情報：
Luo B et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis. Biochim. Biophys. Acta 2013 Aug;1832(8):1260-70
Luo B et al
2013/01/01
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備考：
Species: Rat, Applications: WB -
参照：
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文献情報：
Pawlus MR et al. STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 2013 Apr;
Pawlus MR et al
2013/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Ben-Shoshan J et al. Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties. Stem Cells 2008 Oct;26(10):2634-43
Ben-Shoshan J et al
2008/01/01
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備考：
Species: Human, Applications: ELISA -
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文献情報：
Xie L et al. Transcription Factors Sp1 and Hif2α Mediate Induction of the Copper-transporting ATPase (Atp7a) Gene in Intestinal Epithelial Cells during Hypoxia. J. Biol. Chem. 2013 Aug;288(33):23943-52
Xie L et al
2013/01/01
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備考：
Species: Rat, Applications: WB, ChIP -
参照：
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文献情報：
Forristal CE et al. Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells. PLoS ONE 2013;8(5):e62507
Forristal CE et al
2013/01/01
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備考：
Species: Human, Applications: ChIP -
参照：
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文献情報：
Finley DS et al. Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report. Urol. Oncol. ;29(1):85-9
Finley DS et al
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備考：
Species: Human, Applications: IHC-P -
参照：
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文献情報：
Poitz DM et al. Regulation of the Hif-system by micro-RNA 17 and 20a - Role during monocyte-to-macrophage differentiation. Mol. Immunol. 2013 Jul;56(4):442-451
Poitz DM et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Kim M et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med 2013 Sep;5(9):1415-30
Kim M et al
2013/01/01
-
備考：
Species: Mouse, Applications: IHC-P -
参照：
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文献情報：
Rasbach KA et al. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc. Natl. Acad. Sci. U.S.A. 2010 Dec;107(50):21866-71
Rasbach KA et al
2010/01/01
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備考：
Species: Mouse, Applications: WB -
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文献情報：
Wong WJ et al. MYC Degradation under Low O2 Tension Promotes Survival by Evading Hypoxia-Induced Cell Death. Mol. Cell. Biol. 2013 Sep;33(17):3494-504
Wong WJ et al
2013/01/01
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備考：
Species: Human, Applications: WB -
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文献情報：
Ikeda J et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc 2013 Jun;2(3):e000178
Ikeda J et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
You Q et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem. Pharmacol. 2013 Sep;86(6):836-43
You Q et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
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文献情報：
Sato Y et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat. Genet. 2013 Aug;45(8):860-7
Sato Y et al
2013/01/01
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備考：
Species: Human, Applications: IHC -
参照：
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文献情報：
Brackmann FA et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res. 2013 Sep;1531:65-74
Brackmann FA et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
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文献情報：
Hubbi ME et al. Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors. J. Biol. Chem. 2013 Jul;288(29):20768-75
Hubbi ME et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Xiang L et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J. Mol. Med. 2013 Nov;
Xiang L et al
2013/01/01
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備考：
-
参照：
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文献情報：
Yuan HT et al. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am. J. Pathol. 2003 Dec;163(6):2289-301
Yuan HT et al
2003/01/01
-
備考：
Species: Mouse, Applications: IHC-P, WB -
参照：
- No.： 248
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文献情報：
Luo X et al. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells. Biochim. Biophys. Acta 2014 Jan;1840(1):106-12
Luo X et al
2014/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Natsuizaka M et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012 Jun;26(6):2620-30
Natsuizaka M et al
2012/01/01
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備考：
-
参照：
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文献情報：
Befani C et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int. J. Biochem. Cell Biol. 2013 Nov;45(11):2359-68
Befani C et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
- No.： 251
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文献情報：
Qing G et al. Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res. 2010 Dec;70(24):10351-61
Qing G et al
2010/01/01
-
備考：
Species: Mouse, Human, Applications: WB, IHC -
参照：
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文献情報：
Thapa RJ et al. NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Mol. Cancer Ther. 2013 Aug;12(8):1568-78
Thapa RJ et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Regan Anderson TM et al. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 2013 Sep;73(18):5810-20
Regan Anderson TM et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
- No.： 254
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文献情報：
Takeda K et al. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 2007 Aug;116(7):774-81
Takeda K et al
2007/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
- No.： 255
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文献情報：
Wei K et al. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat. Med. 2013 Oct;19(10):1331-7
Wei K et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
- No.： 256
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文献情報：
Hu CJ et al. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol. Biol. Cell 2007 Nov;18(11):4528-42
Hu CJ et al
2007/01/01
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参照：
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文献情報：
Doedens AL et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat. Immunol. 2013 Nov;14(11):1173-82
Doedens AL et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
- No.： 258
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文献情報：
Kerkel辰 R et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol. Cell. Biol. 2013 Aug;33(16):3321-9
Kerkel辰 R et al
2013/01/01
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備考：
Species: Mouse, Applications: WB -
参照：
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文献情報：
Eckle T et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep;11(9):e1001665
Eckle T et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Duan LJ et al. Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am. J. Pathol. 2011 Apr;178(4):1881-90
Duan LJ et al
2011/01/01
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備考：
Species: Mouse, Applications: WB -
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文献情報：
Costa B et al. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J. 2010 Aug;24(8):2680-8
Costa B et al
2010/01/01
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備考：
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文献情報：
Cowburn AS et al. Epidermal Deletion of HIF-2α Stimulates Wound Closure. J. Invest. Dermatol. 2013 Sep;
Cowburn AS et al
2013/01/01
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備考：
Species: Human, Applications: WB -
参照：
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文献情報：
Pawlus MR et al. STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE 2013;8(8):e72358
Pawlus MR et al
2013/01/01
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備考：
Species: Human, Applications: ChIP, WB -
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