Amorfrutin A | CAS:80489-90-3

• 価格
• 構造式
• 製品情報
• 製品詳細
• 文献

価格

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構造式

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製品情報

Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. fruticosa and G. foetida that exhibits antidiabetic effects. It binds to PPARγ with a K_i of 0.236 µM and activates a PPARγ gene reporter assay with an EC₅₀ value of 0.458 µM. In high-fat diet-induced obese (DIO) mice, amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations. Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 µM.

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製品詳細

name	Amorfrutin A
Formal Name	2-hydroxy-4-methoxy-3-(3-methyl-2-buten-1-yl)-6-(2-phenylethyl)-benzoic acid
CAS Number	80489-90-3
Synonyms	Amorfrutin 1
Molecular Formula	C21H24O4
Formula Weight	340.4
Purity	≥97%
Formulation	A solid
SMILES	OC(C(C(O)=C(C/C=C(C)/C)C(OC)=C1)=C1CCC2=CC=CC=C2)=O
InChI Code	InChI=1S/C21H24O4/c1-14(2)9-12-17-18(25-3)13-16(19(20(17)22)21(23)24)11-10-15-7-5-4-6-8-15/h4-9,13,22H,10-12H2,1-3H3,(H,23,24)
InChI Key	CTNFTPUIYFUXBE-UHFFFAOYSA-N
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
Stability	≥ 2 years

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文献

1. Weidner, C., de Groot, J.C., Prasad, A., et al. Amorfrutins are potent antidiabetic dietary natural products. Proc. Natl. Acad. Sci. USA 109(19), 7257-7262 (2012).

2. Shi, H., Ma, J., Mi, C., et al. Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products. Int. Immunopharmacol. 21(1), 56-62 (2014).

3. Fuhr, L., Rousseau, M., Plauth, A., et al. Amorfrutins are natural PPARg agonists with potent anti-inflammatory properties. J. Nat. Prod. 78(5), 1160-1164 (2015).

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