Flurbiprofen (2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid) | 5104-49-4

name

flurbiprofen

chemical name

2-fluoro-α-methyl-[1,1'-biphenyl]-4-acetic acid

activity

potent inhibitor of cyclooxygenase (ic50 values are 0.1 and 0.4 μm for inhibition of human cox-1 and cox-2 respectively). analgesic, anti-inflammatory and antipyretic in vivo. inhibits tumor cell growth in vitro and in vivo. regulates prostate stem cell antigen through activation of akt kinase. also inhibits fibroblast proliferation in vitro.

MW

244.26

Formula:

c15h13fo2

Solubility:

soluble to 50 mm in ethanol and to 100 mm in dmso

Purity:

>99 %

Storage:

store at rt

CAS No:

5104-49-4

Glenn et al (1973) The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug. Agents Actions 3 210. PMID: 4776365.

Gierse et al (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem.J. 305 479. PMID: 7832763.

Hoferova et al (2002) The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma. Cancer Invest. 20 490. PMID: 12094544.

Zemskova et al (2006) Gene expression profiling in R-flurbiprofen-treated prostate cancer: R-Flurbiprofen regulates prostate stem cell antigen through activation of AKT kinase. Biochem.Pharmacol. 72 1257. PMID: 16949054.