Anandamide (in Tocrisolve™ 100) (Alternative Names: Arachidonylethanolamide, AEA N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide) | 94421-68-8

name

anandamide (in tocrisolve™ 100)

chemical name

alternative names: arachidonylethanolamide, aea n-(2-hydroxyethyl)-5z,8z,11z,14z-eicosatetraenamide

activity

endogenous cannabinoid and vanilloid receptor agonist, in water-soluble emulsion (for details see tocrisolvetm 100, cat. no. 1684). ki values are 89 and 371 nm for cb1 and cb2 receptors respectively; ec50 values are 18, 31 and 27 nm at gpr55, cb1 and cb2 respectively; pki = 5.68 for rvr1. also blocks tnf-α-induced nf-kb activation via direct inhibition of ikk. also available as the pure oil dissolved in ethanol (anandamine, cat. no. 1339). tocrisolve control (cat. no. 1684) also available.

MW

347.54

Formula:

c22h37no2

Storage:

store at +4°c

CAS No:

94421-68-8

Pertwee (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635. PMID: 10469884.

Ross et al (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br.J.Pharmacol. 132 631. PMID: 11159715.

Gardiner et al (2002) Complex regional haemodynamic effects of anandamide in conscious rats. Br.J.Pharmacol. 135 1889. PMID: 11959791.

Kagaya et al (2002) Characterization of the anandamide-induced depolarization of guinea-pig isolated vagus nerve. Br.J.Pharmacol. 137 39. PMID: 12183329.

Sancho et al (2003) Anandamide inhibits nuclear factor-κB activation through a cannabinoid receptor-independent pathway. Mol.Pharmacol. 63 429. PMID: 12527815.

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092. PMID: 17876302.