抗VEGF抗体 | Anti-VEGF antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

WB analysis of recombinant rat VEGF protein using GTX59912 VEGF antibody.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC
Reactivity	Human, Rat

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	0.5-4 μg/ml
IHC	5 μg/ml

Not tested in other applications.

Calculated MW	25 kDa. ( Note )

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PROPERTIES

Form	Liquid
Buffer	PBS pH 7.2, 30% glycerol, 0.5% BSA, 0.01% thimerosal
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Rat
Immunogen	Recombinant rat VEGF expressed from E. coli
Purification	Purified by affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	vascular endothelial growth factor A , VEGF-A , VEGF111 , VEGF164 , VPF , Vegf
Cellular Localization	Secreted
Background	This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Database	・ Gene ID: 83785 Vegfa ・ UniProt: P16612 Vegfa

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Hsu SJ et al. Biosci Rep 2017; 37 (6) The beneficial effects of curcumin in cirrhotic rats with portal hypertension.	Application : WB Reactivity : Rat
Kaya B et al. Mol Clin Oncol 2016; 5 (4) : 343-346 Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma.	Reactivity : Human

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