抗Rb [1F8]抗体 | Anti-Rb [1F8] antibody

• 特長
• 価格
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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製品情報

Host	Mouse
Clonality	Monoclonal
Clone Name	1F8
Isotype	IgG1
Application	WB, IHC-P, IP
Reactivity	Human, Mouse, Rat

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APPLICATION

Application Note

For WB: Use at a dilution of 1:100. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW	106 kDa. ( Note )
Positive Control	K562 WCL

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PROPERTIES

Form	Liquid
Buffer	Phosphate-buffered saline containing 0.1% sodium azide and 0.2% gelatin
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
Concentration	Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Recombinant full length protein (Human).
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	Rb Transcriptional Corepressor 1 , Osrc , Ppp1R130 , Rb , P105-Rb , Prb , Pp110 , Rb1
Cellular Localization	Nuclear
Background	The pocket protein family consists of three structurally and functionally related proteins, Rb, p107, and p130 (1). This family of tumor suppressors function to regulate important cellular transcription factors, such as the E2F family (1,2). The E2F proteins regulate the expression of genes whose products are important for cell cycle progression. The inactivation Rb is catalyzed by CDK phosphorylation thereby releasing E2F during the G1-S phase cellular progression (3). Unchecked inactivation of Rb in G1 phase has been indicated as a universal mechanism underlying cellular transformation (4,5). While Rb has been the most studied among the pocket proteins, p107 and p130 have also been shown to be key regulators of E2F (6). Several studies have also provided evidence that p107/p130 provide different functions in E2F regulation than does Rb (6,7). Rb, p107, and p130 each contain a conserved ?A/B pocket?, which is the target of several viral oncoproteins, namely SV40 large T-antigen and adenovirus E1A (8).
Database	・ Gene ID: 5925 ・ UniProt: P06400

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