抗Caspase 3 (active)抗体 | Anti-Caspase 3 (active) antibody

• 特長
• 価格
• DATA IMAGES
• 製品情報
• APPLICATION
• PROPERTIES
• TARGET
• REFERENCEE(抜粋)

特長

• 高品質の抗体です。
• 幅広い研究分野に関連する抗体を取り揃えています。
• 使用されたアプリケーションや動物種などの情報が充実しています。
• 多数の論文で使用実績がある信頼性の高い抗体です。

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価格

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DATA IMAGES

WB analysis of Jurkat cells treated with camptothecin (2 μM) using GTX22302 Caspase 3 (active) antibody.

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製品情報

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IHC-P, IHC-Fr, IHC
Reactivity	Human, Mouse, Rat, Ferret

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APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Dilution
WB	1:50 -1:500
ICC/IF	Assay dependent
IHC-P	Assay dependent
IHC-Fr	Assay dependent
IHC	1:10-1:20

Not tested in other applications.

Calculated MW	31.61 kDa. ( Note )
Specificity/Sensitivity	The antibody preferentially recognizes the p17 fragment of the active Caspase 3 .

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PROPERTIES

Form	Liquid
Buffer	PBS pH 7.2, 30% glycerol, 0.5% BSA, 5mM EDTA, 0.03% ProClin
Storage	Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration	0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species	Human
Immunogen	Synthetic peptide mapping to the N-terminus adjacent to the cleavage site of human caspase-3
Purification	Purified by affinity chromatography
Conjugation	Unconjugated
Note	For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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TARGET

Synonyms	CASP3 , CPP32 , CPP32B , SCA1 , caspase 3 , Caspase 3
Cellular Localization	Cytoplasm
Background	The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Database	・ Gene ID: 836 CASP3 ・ UniProt: P42574 CASP3

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REFERENCEE(抜粋)

Application Reference	Application/Reactivity
Sawada K et al. IBRO Rep 2019; 7 : 42-51 Follow-up study of subventricular zone progenitors with multiple rounds of cell division during sulcogyrogenesis in the ferret cerebral cortex.	Application : IHC-P Reactivity : Ferret
Liang L et al. J Neurochem 2019; (Epub) Involvement of HIPK2-JNK/c-Jun cascade in the long term synaptic toxicity and cognition impairment induced by neonatal Sevoflurane exposure.	Application : IHC-Fr Reactivity : Rat
Rong Y et al. Hum Vaccin Immunother 2019; An Intranasally Administered Monoclonal Antibody Cocktail Abrogates Ricin Toxin-Induced Pulmonary Tissue Damage and Inflammation.	Application : IHC-P Reactivity : Mouse
KazuhikoSawada et al. IBRO Reports 2019; 7 : 42-51 Follow-up study of subventricular zone progenitors with multiple rounds of cell division during sulcogyrogenesis in the ferret cerebral cortex.	Reactivity : Ferret
Jia R et al. Cell Mol Neurobiol 2019; 39 (6) : 857-869 Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.	Application : IHC-Fr Reactivity : Rat

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