R&D Systems now offers recombinant human Cadherin-13 (Catalog # 3264-CA). Cadherin-13, also known as T-Cadherin and H-Cadherin, is an atypical member of the Cadherin family of glycoproteins that mediate calcium-dependent intercellular adhesion. While most cadherins are transmembrane proteins, Cadherin-13 is anchored to the plasma membrane by a glycosylphosphatidylinositol (GPI) moiety. It is highly expressed in the heart and the central nervous system, and its cellular expression levels in various tissues often correlate, positively or negatively, with the proliferative potential of the cells. Rather than mediate cell adhesion in vivo, Cadherin-13 has been suggested to act as a signaling receptor involved in regulating cell motility and proliferation, or as a tumor suppressor protein.

Cadherin-13 Inhibits Adhesion of Human Umbilical Vein Endothelial Cells. Human umbilical vein endothelial cells (HUVEC) were added to plates coated with the indicated concentrations of recombinant human Cadherin-13 ( Catalog #3264-CA). After two hours, the plates were washed and the number of adherent cells was determined.