R&D Systems is now offering CHO-derived recombinant human BMP-5 (Catalog #615-BMC) and a version of recombinant human Noggin without the Fc fragment (Catalog #6057-NG). Bone morphogenetic protein-5 (BMP-5) is a member of the TGF-beta superfamily that is expressed by chondrocytes in proliferating and hypertrophic zones of bone growth plates. It contributes to limb development by promoting chrondrocyte proliferation and differentiation, and stimulates dendrite outgrowth and dopaminergic neuronal differentiation in the nervous system. Noggin antagonizes BMPs by blocking epitopes that are required for BMP binding to its receptors. During embryogenesis, Noggin inhibits specific BMPs at defined times to regulate skeletal and nervous system development.

BMP-5-Induced Alkaline Phosphatase Production in Mouse Chondrogenic Cells is Inhibited by Noggin. Alkaline phosphatase production in ATDC5 mouse chondrogenic cells was induced by CHO-derived recombinant human BMP-5 (Catalog #615-BMC; purple line). The effect stimulated by BMP-5(1.5 µg/mL) was inhibited by recombinant human Noggin/Fc chimera (Catalog #3344-NG; orange line) or free recombinant human Noggin (Catalog #6057-NG; blue line).