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フナコシ / フナコシ(株)
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[Date:September 04 2014]

Natural Killer T (NKT) cells activator Alpha-GalCer (KRN7000) and 7DW8-5

Common Features of KRN7000 and 7DW8-5

  • Immunostimulant
  • Potent stimulator of human and mouse natural killer T (NKT) cells.
  • Potent antitumor compound.

Alpha-GalCer (KRN7000)

Natural Killer T (NKT) cells activator : Alpha-GalCer (KRN7000)

Specific ligand for human and mouse NKT cells.
Alpha-GalCer (KRN7000) exhibits various immunological effects through NKT cell functions including potent antitumor effect.

Features

  • Chemical Name : (2S, 3S, 4R)-1-O-(alpha-D-galactosyl)-N-hexacosanoyl-2-amino-1, 3, 4-octadecanetriol
  • Mol. Formula : C50H99NO9
  • Mol. Weight : 858.34
  • Chemically synthesized glycolipid soluble in DMSO
  • Activates CD1d mediated invariant NKT cells (iNKT cells)
  • Both Th1 and Th2 cytokine are released after activation by KRN7000.

Note: Alpha-GalCer (KRN7000) is for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of Kyowa Hakko Kirin Company.
Kyowa Hakko Kirin Company has issued a worldwide license for KRN7000 research to Funakoshi Company.

Supplier Product Code Product Name Size Price
KRNフナコシ
フナコシ(株)

Datasheet

KRN7000

alpha-Galactosylceramide <α-GalCer>, <KRN7000>

1mg

$220
Supplier Product Code Product Name Size Price
KRNフナコシ
フナコシ(株)

KRN7000

alpha-Galactosylceramide <α-GalCer>, <KRN7000>

1mg

$220
Description

KRN7000, a glycolipid derived from the marine sponge has a novel α-galactosylceramide (α-GalCer) structure and exhibits potent anti-tumor activity by stimulating a strong immune response.

Detailed informations on "Alpha-GalCer.net".
http://www.alpha-galcer.net/

Storage-20°CCAS
LinkAlpha-GalCer (KRN7000) and 7DW8-5

7DW8-5

Natural Killer T (NKT) cells activator  : 7DW8-5

The 7DW8-5 is a newly developed derivative of Alpha-GalCer.
This compound shows higher affinity with the V14TCR on NKT cells than Alpha-GalCer. The 7DW8-5 can be used as a potential immunotherapeutic reagent against cancer, infectious disease and autoimmune disease models.

Features

  • Glycolipid derivative of Alpha-GalCer
  • Chemical Name : (2S, 3S, 4R)-1-O-(alpha-D-galactopyranosyl)-N-(11-(4-fluorophenyl)undecanoyl) -2-amino-1, 3, 4-octadecanetriol)
  • Mol. Formula : C41H72FNO9
  • Mol. Weight : 742.00
  • Purity : 98% by HPLC
  • Soluble in DMSO
  • Has ~100 times stronger adjuvant effect than KRN7000.

Note: 7DW8-5 is licensed by The Rockefeller University.

Alpha-GalCer has wide research and human therapeutic applications.
Please learn and find more information at "Alpha-GalCer.net"

Supplier Product Code Product Name Size Price
FRKフナコシ
フナコシ(株)

Datasheet

7DW8-5

7DW8-5

1mg

$448
Supplier Product Code Product Name Size Price
FRKフナコシ
フナコシ(株)

7DW8-5

7DW8-5

1mg

$448
Description

Derivative of αGal-Cer.
It could be used as a potential immunotherapeutic to treat cancer, infectious diseases, and autoimmune diseases.

Detailed informations on "Alpha-GalCer.net".
http://www.alpha-galcer.net/

Storage-20°CCAS
LinkAlpha-GalCer (KRN7000) and 7DW8-5

Contact

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