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フナコシ株式会社
フナコシ / フナコシ株式会社
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[Date:December 22 2017]

New mitochondria uncoupling agent Ppc-1

Increasing mitochondria's oxigen consumption without inhibiting ATP synthesis
Ppc-1, MitoUncoupler

Ppc-1 is a newly isolated molecule from Polysphondylium pseudo-candidum. It shows comparatively mild uncoupling activity in Mitochodria.

Ppc-1 is a newly isolated molecule from Polysphondylium pseudo-candidum.
It shows comparatively mild uncoupling activity in Mitochodria.

According to papers, following effects are reported in Ppc-1.

  • Ppc-1 stimulates oxygen consumption without inhibiting ATP synthesis in mitochondria, isolated from mouse liver. 1), 2)
  • Ppc-1 administrated mouse shows inhibition of weight gain, without affecting liver and kidney. 1), 2)
  • Cell proliferation is inhibited without inducing cell death, in Ppc-1 treated 3T3-L1 cells. 3)

Features

  • Comparatively mild uncoupling activity
  • Low effect on ATP synthesis or degradation
  • Low active oxygen generation
  • Low cytotoxicity
  • Cell proliferation is inhibited by adding Ppc-1 to culture medium.
  • Chemical Name :3-Methylbut-2-enyl 4-methoxy-8-(3-methylbut-2-enyloxy)quinoline-2-carboxylate
  • CAS number :1245818-17-0
  • Molecular Formula :C21H25NO4
  • Molecular Weight :355.43
  • Purity :≧98%
  • Soluble in DMSO

Reference

1) Suzuki T, et. al, PLoS One. 2015 Feb10; 10(2):e0117088.
2) Kikuchi H, et. al, Bioorg Med Chem., 23(1): 66-72(2015).
3) Kikuchi H, et. al, Tetrahedron, 66: 6000-6007(2010).

Supplier Product Code Product Name Size Price
FNAフナコシ
フナコシ株式会社

Datasheet

FDV-0011

Ppc-1, MitoUncoupler

5mg

$200
Supplier Product Code Product Name Size Price
FNAフナコシ
フナコシ株式会社

FDV-0011

Ppc-1, MitoUncoupler

5mg

$200
Description

Storage-20°CCAS1245818-17-0
LinkPpc-1

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