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フナコシ株式会社
フナコシ / フナコシ株式会社
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[Date:December 22 2017]

Newly developed immunosuppressor PQA-18

PQA-18

PQA-18 is a newly developed immunosuppressor. PQA-18 strongly inhibits p21-activated kinase 2 (PAK2), which is related to IL-2, IL-4, IL-6 and TNF-alpha production.

PQA-18 is the abbreviation of "Prenylated Quinolinecarboxylic Acid compound 18", and following effects are reported.

  • PAK2 activity is reduced in a dose-dependent manner, when PQA-18 is added to Jurkat cells.
  • IL-2, IL-4, IL-6 and TNF-alpha production are reduced, when PQA-18 is added to human peripheral lymphocytes stimulated for 24 hours by ConA (10 ug/ml).
  • Antigen specific immune reactions is inhibited when PQA-18 is intraperitoneally administered to mouse.
  • Nc/Nga mouse (13 weeks old), applied petrolatum ointment (100 mg) containing PQA-18 shows less skin irritation and blood IgE amount is reduced.

Features

  • Higher stability in blood compared to FK-506.
  • Compatible with in vivo and in vitro application.
  • CAS number : 1604678-82-1
  • Molecular Formula : C25H31NO4
  • Molecular Weight (Average) : 409.52
  • Purity : >98%
  • Solubility : DMSO *
  • * If you see insoluble, try vortex or heat at 37C. Recommended stock solution concentration is 10 - 20 mM.

    Example Data

    PQA-18 Example Data

    PQA-18 is added to Jurkat cells. IL-2 production is reduced in a dose-dependent manner.

    Reference

    Ogura M, et al, Biochem Pharmacol, 105:55-65 (2016).

    Price

    Supplier Product Code Product Name Size Price
    FNAフナコシ
    フナコシ株式会社

    Datasheet

    FDV-0009

    PQA-18, Immunosuppressor

    5mg

    $200
    Supplier Product Code Product Name Size Price
    FNAフナコシ
    フナコシ株式会社

    FDV-0009

    PQA-18, Immunosuppressor

    5mg

    $200
    Description

    Newly developed immunosuppressor, inhibits PAK2.

    Storage-20°CCAS1604678-82-1
    LinkPQA-18

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