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| ELISA / EIA kit |
| Prolyl 4-Hydroxylated Human α-Fibrinogen ELISA Kit | |||||
| Maker | TRG | Cat.No. | KG612 | Size | 1kit |
| price | $1,154 | Storage | 4℃ | CAS | |
| Data Sheet |  |
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| Description | Assay Range : 2.73 - 175 ng/mL Sample : EDTA-Plasma, Culture Supernatant Fibrinogen is one of major component of plasma, and is a hexamer composed of pairs of three polypeptides (α-, β- and γ-chain). Prolyl hydroxylation is known to be essential for folding, secretion, and stability of collagen triple helix. In the powerful study using 2-Dimensional Image Converted Analysis of Liquid chromatography and mass spectrometry (2DICAL), it is found that proline 565 and 530 residues in α-fibrinogen is hydroxylated by the Prolyl hydroxylase P4HA1. In addition, the plasma level of prolyl 4-hydroxylated α-fibrinogen (HP-FGA) was increased in individuals who suffer pancreatic cancer. The significant difference between the said group (n=43) and healthy subjects (n=43) was observed in the 2-DICAL analysis. | ||||
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