使用文献多数のオートファジー関連抗体 Most Cited Autophagy related Antibody

Autophagy (auto-self; phage-eating) is a lysosomal degradative process that allows cells to recycle essential cellular constituents and dispose of damaged organelles and protein aggregates. Autophagy occurs at low basal levels in all cells to maintain homeostatic functions. It is rapidly upregulated when cells need to generate intracellular nutrients andenergy during starvation, growth factor withdrawal, or high bioenergetic demands. Autophagy is also important process to dispose of damaging cytoplasmic components during oxidative stress,infection or protein aggregate accumulation. Consequently, impairment in autophagy can lead to development of certain pathological conditions.