試薬記事カテゴリー

R&D Systems, Inc..(R&D Systemsは,テクネ コーポレイションの登録商標です)
アールアンドディー システムス / R&D Systems, Inc..(R&D Systemsは,テクネ コーポレイションの登録商標です)
Webページ番号:
[掲載日情報:2017/12/01 現在]

R&D Systems社 Adipocytokines & Insulin Signalingの関連製品 Adipocytokines & Insulin Signaling

アディポカイン-インスリンシグナル伝達のパスウェイマップのご紹介です。
下線を引いたパスウェイの各因子について,下記検索フォームからR&D Systems社の関連製品を検索いただけます。




パスウェイ

Overview of Adipocytokines & Insulin Signaling

Insulin, secreted by pancreatic beta cells, is the main regulator of blood glucose levels. It inhibits glucose production in the liver, stimulates glucose uptake in muscle and fat, promotes glycogen and lipid synthesis, and inhibits lipolysis. Insulin signaling promotes glucose uptake by activating intracellular signaling pathways that promote translocation of the GLUT4 glucose transporter to the plasma membrane. Additionally, insulin signaling inactivates GSK-3, which keeps Glycogen Synthase active, thereby promoting storage of glucose as glycogen. Insulin signaling can be enhanced or inhibited by adipocytokines secreted by the adipose tissue. The ability of these cytokines to influence insulin signaling suggests that changes in their levels may contribute to the development of insulin-related metabolic disorders such as Type II diabetes. In support of this hypothesis, one of the leading risk factors for Type II diabetes is obesity, a condition characterized by an increase in adipose tissue mass, altered adipocytokine secretion, and chronic inflammation. Obesity is associated with reduced Leptin sensitivity and decreased Adiponectin production, two adipocytokines that normally enhance insulin sensitivity. These changes are coupled with an increase in the production of pro-inflammatory cytokines such as TNF-alpha and IL-6, which can negatively affect adipose tissue functions and promote insulin resistance. Characterizing the mechanisms by which adipocytokines enhance or interfere with insulin signaling pathways is critical to our understanding of how these factors may contribute to the pathogenesis of metabolic disorders.

お問い合わせ先(テクニカルサポート 試薬担当)

製品情報は掲載時点のものですが、価格表内の価格については随時最新のものに更新されます。お問い合わせいただくタイミングにより製品情報・価格などは変更されている場合があります。

表示価格に、消費税等は含まれていません。一部価格が予告なく変更される場合がありますので、あらかじめご了承下さい。

トップに戻る